Science and technology is known as a two-blade sword. For on one hand, the scientific development has brought human incredible advantages, while on the other hand, it has also lead to many dilemmas between science and ethics. For instance, technologies such as test-tube baby, artificial fertilization and in vitro fertilization, and cloning have drawn a lot of attention. A serous reflection should be given to ethics-related issues caused by these high-tech products.

The paper first made a review of the literature on the pharmacology and clinical use of cisplatin. An analysis was then made of 24 cases (18 cases of stage I and 6 cases of stage IV)of advanced ovarian cancer treated with intraperitoneal injection of cisplatin in combination with cytoreductive operation and other chemotherapy. The follow-up observation indicates that the complete response rate and partial response rate is 58% and 25% respectively,making up a total effective rate of 83%.

OBJECTIVE: To introduce the general situation of the internal clinical studies about electro-acupuncture in treating depressive disorders during the recent 20 years so as to investigate further the effectiveness and safety of electro-acupuncture in treating depressive disorders.DATA SOURCES: A computer-based online search of Pubmed database and Chinese biomedical literature database (CBM) was undertaken to identify relevant articles published in Chinese between 1984 and 2004 with the keywords of "electro-acupuncture, depression".STUDY SELECTION: The data were checked firstly, and the full-texts of clinical trials were searched. Inclusion criteria: ① having definite diagnostic criteria; ② randomized control study or control trial; ③ the interventions in the treatment group should be electro-acupuncture or electroacupuncture combined with antidepressant drugs or electro-acupuncture combined with placebo, and those in the control group should be antidepressant drugs, antidepressant drugs combined with modeling electroacupuncture and only electro-acupuncture or without antidepressant measures. Exclusion criteria: ① non-control study; ② the interventions in the treatment group or control group did not accord with the inclusive criteria;③ mechanism study; ④ repetitive study.DATA EXTRACTION: In total 99 relevant articles were collected and 15 were selected according to the in clusive criteria and the others were excluded.DATA SYNTHESIS: Of the 15 articles, 12 were randomized control studies and 3 were control studies. The studies all lasted 1-1.5 months, all were completed in China, and the number of patients was 30-241. Six studies compared the effect and safety in treating depression between electro-acupuncture and traditional antidepressant drug therapy, 2 studies compared the effect of electro-acupuncture and new antidepressant drug, 4studies observed the effect of electro-acupuncture combined with drug and drug 9r electro-acupuncture only on depression, 1 study compared the effect of electro-acupuncture with that of western medicine in the treatment of depression, and 2 studies observed the role of electro-acupuncture in treating post-stroke depression.CONCLUSION: Electro-acupuncture has the similar effect of western antidepressant drug in treating depressive disorders; moreover, it has the advantages of fewer side effects, higher safety and easier acceptance of the patients, etc. There are fewer clinical studies of large samples and strictly following the randomized control and blinded principle, so clinical studies of high quality are still needed to provide more powerful evidences.

Objective Explore the impact of maintenance hemodialysis patients with treatment compliance of the relevant factors.Methods clinical data of our hospital from January 2006 to December 2008 120 cases of maintenance hemodialysis patients were retrospectively analyzed,and the factors of affecting compliance were carried out with the single factor analysis and Logistic regression analysis.Result 120 patients with good drug compliance ih 50 cases,41.6%;X~2 single factor analysis of a total of nine selected factors that affect compliance,logistic regression analysis selected hemodialysis poor awareness of knowledge,a monthly income of less time for the initial stage of dialysis,family social support is poor compliance with an independent risk factor.Conclusion Hemodialysis patients with low compliance,depending on many factors,the above-mentioned factors should take effective measures to improve their compliance.

Objective To observe the therapeutic effect of treating myocardial ischemia in CHD with Junanyin. Methods All patients with myocardial ischemia in CHD were randomly recruited into a control group and a treatment group,with 43 patients in each group. The treatment group was treated with Junanyin, one dose daily, on the basis of conventional treatment; while the control group was treated with Huoxuezhuyu decoction on on the basis of conventional treatment, one dose daily. The results were compared after 8 weeks. Results The outstanding cure rate and total effective rate in the treatment group were both statically better than the control group, with (χ2=9.53, P＜0.05) and (χ2=19.5, P＜0.05)respecitvely. Conclusion Junanyin was effective to treat myocardial ischemia in CHD.

Crigler-Najjar Syndrome ; genetics ; Gilbert Disease ; genetics ; Glucosephosphate Dehydrogenase Deficiency ; genetics ; Glucuronosyltransferase ; genetics ; Humans ; Infant, Newborn ; Jaundice, Neonatal ; genetics ; Polymorphism, Genetic

Objective: To investigate the efficacy and safety of a composite treatment with stone scraping, cupping, electroacupuncture and infrared irradiation for neck-type cervical spondylosis.Methods: Seventy subjects were randomly allocated into composite treatment group (35 cases) and control group (35 cases). The composite treatment group was treated by scraping along the Governor Meridian, the Gallbladder Meridian and the Bladder Meridian with Geng's multifunctional stone plate, quick cupping with subsequent retention of cups, routine electroacupuncture, and infrared irradiation. The control group was treated by routine electroacupuncture and infrared irradiation. Both groups were treated once very other day, 6 times as a course. The clinical curative effects and adverse responses were evaluated immediately after each treatment and at the completion of one course of treatment in both groups. Results: The total immediate effective rate was 88.6% in the composite treatment group and 80.0% in the control group. The immediate effect was significantly better in the composite treatment group than in the control group (P＜0.05). The total effective rate at the completion of one course of treatment was 97.1% in the composite treatment group and 94.3% in the control group. The curative effect after one course of treatment was also significantly better in the composite treatment group than in the control group (P＜0.05). Conclusion: Composite treatment with acupuncture, stone scraping and cupping is safe and effective in treating neck-type cervical spondylosis

Objective To observe the effect of clinical nursing pathway used in double-C treatment of elderly patients with type 2 diabetes.Methods 140 elderly type 2 diabetic patients were randomly divided into the control group and the experimental group with 70 cases in each group,both groups adopted double C treatment.The control group received routine care,on the basis of routine nursing care,the experimental group implemented CNP mode.After treatment,type 2 diabetes knowledge mastering levels,the number of days of blood glucose reaching standard level,insulin dosage,incidence of hypoglycemia,satisfaction degree with quality of care,compliance rate and passing rate of health education were compared.Results After treatment,for patients with good compliance rate,the control group accounted for 50.00％,the experimental group accounted for 68.57％,the compliance rate of the experimental group was better than the control group.The incidence of hypoglycemia in the control group was 10.00％,and 1.43％ in the experimental group.The kn owledge mastering levels and satisfying rate with nursing care were 67.14％ and 82.86％ in the control group,and 95.71％ and 98.57％ in the experimental group.The number of days of blood glucose reaching standard level,insulin dosage,passing score of health education were (8.35 ± 1.41) d,(60.36±9.23) U/d,(65.20±3.42) points in the control group,and (4.68±1.32) d,(42.34±7.74) U/d,(90.15±2.15) points in the experimental group.The results of the experimental group were better than those of the control group.Conclusions The clinical nursing pathway in double C treatment of elderly patients with type 2 diabetes demonstrates the advantages of advance,orderly and efficiency,which is worthy of further research and extension.

Objective To investigate the quality of life (QOL) of dysphagic patients after stroke and the factors related to it. Methods One hundred patients with dysphagia after stroke from January, 2014 to February, 2015 were investigated with the Swallowing Disorder Pa-tients Quality of Life Scale (SWAL-QOL). The general and special data of the patients were collected, and were analyzed with univariate analysis and Ordinal regression. Results With univariate analysis, there was significant difference in scores of SWAL-QOL among the pa-tients of various ages, courses, education levels, complications, treatment time, ways of eating, grades of drinking water test and swallowing function scores (P<0.01). Ordinal regression analysis showed that the high scores of SWAL-QOL was more probable in the patients aged 50-59 years old, with higher education level, no complication and less grade of drinking water test. Conclusion Intervention targeted to the risk factors may improve the QOL of patients with dysphagia after stroke.

Objective To observe effect and toxicity reaction using the treatment of Docetaxel combined with Gimeracil and Oteracil porassium capsules or capecitabine on elderly patients with advanced gastric cancer.Methods Sventy-eight cases elderly patients with advanced gastric cancer were divided into the combination group (n =40) and the monotherapy group (n =38) randomly by the random number table from February 2010 to December 2012.The patients on the monotherapy group were treated with capecitabine or oral Gimeracil and Oteracil porassium capsules,while the patients on the combination group were treated with Docetaxel in combination of capecitabine or Gimeracil and Oteracil porassium capsules.All therapy were repeated each 3 weeks,and 2 cycles chemotherapy were done at least;meanwhile effect and toxicity reaction were evaluated.At last,time to progress(TTP),median survival time(MST),1-year survival rate and 2-year survival rate were evaluated after completion of follow-up.Results On one other,response rate of the combination group and the monotherapy group were 95％ (38/40) and 79.0％ (30/38),and patients were 38 and 30,respectively;and response rate of the combination group was higher than the monotherapy group(x2 =4.4928;P＜0.05).TTP were 7.9 and 7.6 months on the combination group and the monotherapy group,and the MST were 13.1 months and 12.6 months respectively.The 1-year survival rate were 32.5％,28.95％,and 2-year survival 15.0％,5.27％,similarly,there was no remarkable significance on survival rate(x2=0.12,2.01,P＞0.05).On the other hand,the combination group exhibited more remarkable significance of toxicity reaction than the monotherapy group(P＜0.05),such as hepatotoxicity,baldness,hepatic injury.Conclusion Effect of the combination group was superior to the monotherapy group on elderly patients with advanced gastric cancer.However,there is no longer survival time and more toxicity reaction on the combination group.