Science and technology is known as a two-blade sword. For on one hand, the scientific development has brought human incredible advantages, while on the other hand, it has also lead to many dilemmas between science and ethics. For instance, technologies such as test-tube baby, artificial fertilization and in vitro fertilization, and cloning have drawn a lot of attention. A serous reflection should be given to ethics-related issues caused by these high-tech products.

Objective To observe clinical effect of treating chronic sinusitis and nasal polyps with endoscopic sinus surgery combined with Chinese medicine. Methods 65 patients with chronic sinusitis and nasal polyps were randomly divided into a control group and a treatment group. The control group was treated with endoscopic sinus surgery only, and the treatment group was treated with endoscopic sinus surgery combined with Chinese medicine. Results The total effective rate in the treatment group and the control group was 90.9% and 75.0%, respectively. There was a significant dieffference between two groups (P= 0.0416, P<0.05 ). Conclusion The treatment of endoscopic sinus surgery combined with Chinese medicine on chronic sinusitis and nasal polyps is better than endoscopic sinus surgery only.

This article introduces a multiplying channel pulse tracings detection system based on the three-part theory of pulse examination in traditional Chinese medicine which can be applied in experimental animals.Managed multiplex transducer spikes were transmitted to the computer by USB,then matched with per se developmental data analysis and processings of tware,could get the pressure sphygmogram,one circuitry standard electrocardio-signal and one circuitry photoelectricity cubage sphygmogram in the three different parts.It has good effect though by primary animal experiments.

The paper first made a review of the literature on the pharmacology and clinical use of cisplatin. An analysis was then made of 24 cases (18 cases of stage I and 6 cases of stage IV)of advanced ovarian cancer treated with intraperitoneal injection of cisplatin in combination with cytoreductive operation and other chemotherapy. The follow-up observation indicates that the complete response rate and partial response rate is 58% and 25% respectively,making up a total effective rate of 83%.

OBJECTIVE: To introduce the general situation of the internal clinical studies about electro-acupuncture in treating depressive disorders during the recent 20 years so as to investigate further the effectiveness and safety of electro-acupuncture in treating depressive disorders.DATA SOURCES: A computer-based online search of Pubmed database and Chinese biomedical literature database (CBM) was undertaken to identify relevant articles published in Chinese between 1984 and 2004 with the keywords of "electro-acupuncture, depression".STUDY SELECTION: The data were checked firstly, and the full-texts of clinical trials were searched. Inclusion criteria: ① having definite diagnostic criteria; ② randomized control study or control trial; ③ the interventions in the treatment group should be electro-acupuncture or electroacupuncture combined with antidepressant drugs or electro-acupuncture combined with placebo, and those in the control group should be antidepressant drugs, antidepressant drugs combined with modeling electroacupuncture and only electro-acupuncture or without antidepressant measures. Exclusion criteria: ① non-control study; ② the interventions in the treatment group or control group did not accord with the inclusive criteria;③ mechanism study; ④ repetitive study.DATA EXTRACTION: In total 99 relevant articles were collected and 15 were selected according to the in clusive criteria and the others were excluded.DATA SYNTHESIS: Of the 15 articles, 12 were randomized control studies and 3 were control studies. The studies all lasted 1-1.5 months, all were completed in China, and the number of patients was 30-241. Six studies compared the effect and safety in treating depression between electro-acupuncture and traditional antidepressant drug therapy, 2 studies compared the effect of electro-acupuncture and new antidepressant drug, 4studies observed the effect of electro-acupuncture combined with drug and drug 9r electro-acupuncture only on depression, 1 study compared the effect of electro-acupuncture with that of western medicine in the treatment of depression, and 2 studies observed the role of electro-acupuncture in treating post-stroke depression.CONCLUSION: Electro-acupuncture has the similar effect of western antidepressant drug in treating depressive disorders; moreover, it has the advantages of fewer side effects, higher safety and easier acceptance of the patients, etc. There are fewer clinical studies of large samples and strictly following the randomized control and blinded principle, so clinical studies of high quality are still needed to provide more powerful evidences.

Crigler-Najjar Syndrome ; genetics ; Gilbert Disease ; genetics ; Glucosephosphate Dehydrogenase Deficiency ; genetics ; Glucuronosyltransferase ; genetics ; Humans ; Infant, Newborn ; Jaundice, Neonatal ; genetics ; Polymorphism, Genetic

Objective Explore the impact of maintenance hemodialysis patients with treatment compliance of the relevant factors.Methods clinical data of our hospital from January 2006 to December 2008 120 cases of maintenance hemodialysis patients were retrospectively analyzed,and the factors of affecting compliance were carried out with the single factor analysis and Logistic regression analysis.Result 120 patients with good drug compliance ih 50 cases,41.6%;X~2 single factor analysis of a total of nine selected factors that affect compliance,logistic regression analysis selected hemodialysis poor awareness of knowledge,a monthly income of less time for the initial stage of dialysis,family social support is poor compliance with an independent risk factor.Conclusion Hemodialysis patients with low compliance,depending on many factors,the above-mentioned factors should take effective measures to improve their compliance.

Objective To investigate the quality of life (QOL) of dysphagic patients after stroke and the factors related to it. Methods One hundred patients with dysphagia after stroke from January, 2014 to February, 2015 were investigated with the Swallowing Disorder Pa-tients Quality of Life Scale (SWAL-QOL). The general and special data of the patients were collected, and were analyzed with univariate analysis and Ordinal regression. Results With univariate analysis, there was significant difference in scores of SWAL-QOL among the pa-tients of various ages, courses, education levels, complications, treatment time, ways of eating, grades of drinking water test and swallowing function scores (P<0.01). Ordinal regression analysis showed that the high scores of SWAL-QOL was more probable in the patients aged 50-59 years old, with higher education level, no complication and less grade of drinking water test. Conclusion Intervention targeted to the risk factors may improve the QOL of patients with dysphagia after stroke.

OBJECTIVE:To establish a method of contents determination of 17 amino acids in Fritillariae Pallidiflorae Bulbus produced in Xinjiang. METHODS:Cation-exchange column was used to separate 17 kinds of amino acids;post-column derivatiza-tion liquid chromatography was used to determine the contents of amino acids:the column was strong sulfonic acid cation exchange resin LCAK06/Na with mobile phase A(weighing trisodium citrate 11.9 g,citric acid 6 g,phenol 1 g,dissolving by water,then adding 65 mL of methanol and 6 mL of concentrated hydrochloric acid,bringing the volume with tap water,adjusting pH to 3.4), mobile phase B(weighing trisodium citrate 11.9 g,NaOH 2.8 g,phenol 1 g,boric acid 5.0 g,adding water to dissolve,adjustingpH to 10.8),gradient elution,flow rate was 0.45 mL/min for A pump and 0.25 mL/min for M pump,the detection wavelength was 440 nm for proline and 570 nm for the remaining amino acids,the injection volume was 50 μL. RESULTS:The linear range were 20~400 nmol/mL of aspartic acid,threonine,serine,glutamic acid,glycine,alanine,valine,methionine,isoleucine,leucine,ty-rosine,phenylalanine,histidine,lysine,arginine,proline,10-200 nmol/mL of cystine(r were higher than 0.9890);RSDs of preci-sion,stability and reproducibility tests were lower than 2.0%;limits of detection were 0.16 nmol/mL except for cystine(0.08 nmol/mL);recovery was 98.5%-99.5%(RSD was 0.06%-0.21%,n=6). CONCLUSIONS:The method is simple with good precision, stability and reproducibility,and can be used for the simultaneous determination of amino acids in Fritillariae Pallidiflorae Bulbus produced in Xinjiang.

Objective To observe effect and toxicity reaction using the treatment of Docetaxel combined with Gimeracil and Oteracil porassium capsules or capecitabine on elderly patients with advanced gastric cancer.Methods Sventy-eight cases elderly patients with advanced gastric cancer were divided into the combination group (n =40) and the monotherapy group (n =38) randomly by the random number table from February 2010 to December 2012.The patients on the monotherapy group were treated with capecitabine or oral Gimeracil and Oteracil porassium capsules,while the patients on the combination group were treated with Docetaxel in combination of capecitabine or Gimeracil and Oteracil porassium capsules.All therapy were repeated each 3 weeks,and 2 cycles chemotherapy were done at least;meanwhile effect and toxicity reaction were evaluated.At last,time to progress(TTP),median survival time(MST),1-year survival rate and 2-year survival rate were evaluated after completion of follow-up.Results On one other,response rate of the combination group and the monotherapy group were 95％ (38/40) and 79.0％ (30/38),and patients were 38 and 30,respectively;and response rate of the combination group was higher than the monotherapy group(x2 =4.4928;P＜0.05).TTP were 7.9 and 7.6 months on the combination group and the monotherapy group,and the MST were 13.1 months and 12.6 months respectively.The 1-year survival rate were 32.5％,28.95％,and 2-year survival 15.0％,5.27％,similarly,there was no remarkable significance on survival rate(x2=0.12,2.01,P＞0.05).On the other hand,the combination group exhibited more remarkable significance of toxicity reaction than the monotherapy group(P＜0.05),such as hepatotoxicity,baldness,hepatic injury.Conclusion Effect of the combination group was superior to the monotherapy group on elderly patients with advanced gastric cancer.However,there is no longer survival time and more toxicity reaction on the combination group.