No abstract available.
Korea*

BACKGROUND: During the past half century we have learned much about the functions of the stratum corneum but very little has been proven. Stratum corneum daes not represent the anatomy of this layer in the usual formalira fixed histological preparation. Several techniques have been developed over, the past decades to study the desquamating portion of the humain stratum corneum. There are several methods to measure the serface area of keratinocyte such as a plar,imeter, a graphic tablet and an automatic cytographic counter. OBJECTIVE: The purpose of this study is to find out the accuracy of different measuring devices. METHOD: Standard figures such as a pentagon, a hexagon and a circle, simulating the figure of keratinocyte are used toneasure srea. Repeated measurements of the areas by planimeter, graphic tablet and automatic cytographic counter were analysed by statiatic. RESULT: The planimeter had the advantage of measuring the entire visible area by microscope and a low mean absolute percent error (MAPE) (0.3%), but it needed skill to reduce error and more MAPE (0.5%). Graphic tablet was less time consuming, but had similar advantages of the plarimeter, and needed also skill. On the other hand, the automatic cytographic counter(YK-1) had a very short measuring time and needed less skill, but required good contrast stairing of in order to measure area. CONCLUSION: Comparing the accurracy of three measuring devices of area, the MAPE of the planimeter was 0.3%, the MAPE of YK-1 was 0.5% and the MAPE of graphic tablet was 0.5%.
Hand ; Keratinocytes

Nevus lipomatosus superficialis is a rare. disease entity characterized by ectopic dermal fat cells. The lesions are usually either congenital or present by the second decade of life and occur pre-dominantly in the pelvic area. There´are usually no associated abnormalities and familial incidence is not yet reported in English language literature. The authors report a familial case of nevus lipomatosus superficialis with characteristic light and electron microscopic findings.
Adipocytes ; Incidence ; Nevus*

We Report a hibernoma which ocurred in a 30-year-old male, who had 2cm sized, well-marginated, subcutaneous mass on the right side of the scapula. Histopathologic finding showed the tumor was composed of uniform granular or multivacuolated, eosinophilic, round to ovoid cells with small and peripherally plnced nuclei. Total exrision of the tumor was performed. No recurrence was observed for 5 months after surgical excision.
Adult ; Eosinophils ; Humans ; Lipoma* ; Male ; Recurrence ; Scapula

Syringomas are relatively common benign adnexal tumors that are usually located on the lower eyelids, although affecting other areas, including cheek, axillae, abdomen and vulva. Acral syringomas, located on distal extremities are vary rare and there is only one case reported in Korea. We report a case of a healthy 21-year-old woman with multiple, reddish brown syringomas located on both forearms and the dorsa of hands. The histologic findings were typical of syringomas.
Abdomen ; Axilla ; Cheek ; Extremities ; Eyelids ; Female ; Forearm ; Hand ; Humans ; Korea ; Syringoma* ; Vulva ; Young Adult

No abstract available.
Nevus, Epithelioid and Spindle Cell*

Ehlers-Danlos syndrome is an inherited disorder of connective tissue in which joint hypermobility, hyperelasticity of skin, bleeding tendency, and scar formation are the most prominent features. It is a generalized disease with essentially universal involvement. A 3-year-old female child had velvety skin, skin hyperextensibility, joint hypermobility, subcutaneous mobile masses on the left shin, many scars on both knees, subcutaneous hematoma, and thick and very folded skin on both palms and soles, but no evidence of internal disorder. Cutaneous histopathologic findings were nonspecific without increase of dermal elastic fibers on Verhoeff stain. Diagnosis was confirmed by clinical and histopathological findings as Ehlers-DanIos syndrome.
Child ; Child, Preschool ; Cicatrix ; Connective Tissue ; Diagnosis ; Ehlers-Danlos Syndrome ; Elastic Tissue ; Female ; Hematoma ; Hemorrhage ; Humans ; Joint Instability ; Knee ; Skin

Sustainable rates of sebum excretion(SRSE) was measured in seven women who had normal regular periods, none were taking oral contraceptives with no significant signs of acne or hirsutism, with assays for testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, and progesterone during menstrual cycle. The SRSE in omen during the follicular phase wa lower in the luteal phase (p <0.01)than in the men (p <0.01). However during the luteal phase the SRSE in the women was increased similar to the SESE in the men. We investigated the above horrnoies in relationship to the SRSE during the women's menstrua] cycle. During the follicular phase the hormone which was the most determining factor affected the SRSl was total testerone, while dihydrotestosterone was the most determining factor of the horrnone affecting the SRSE during the ovulation and luteal phase.
Acne Vulgaris ; Contraceptives, Oral ; Dehydroepiandrosterone Sulfate ; Dihydrotestosterone ; Female ; Follicular Phase ; Hirsutism ; Humans ; Luteal Phase ; Male ; Menstrual Cycle* ; Ovulation ; Progesterone ; Sebum* ; Testosterone

A few cases of a dermatosis characterized by "music box spine" keratotic papules limited to the palms and soles have been reported. There have been several names for this dermatosis The Most commonly incorporated term is porokeratosis, but Osman et at suggested the name "spiny keratoderma of palms and soles" because the clinical, histologic and electron microscopic features of this lesion are distinct from porokeratosis. We report a case of spiny keratoderma on the digit showing a single lesion, as a variant of the classic spiny keratoderma of palms and soles.
Porokeratosis ; Skin Diseases

BACKGROUND: The epidermal permeability barrier necessary for terrestrial life resides in the intercellular spaces of the stratum corneum and is composed of lipids. OBJECTIVE: Since strrtum corneum lipid may be important for the permeability barrier, we studied the differences and effects of experimentally altered barrier function using acetone and tape-stripping technique. METHODS: The permeability barrier of hairless mouse was disrupted by tape-stripping and acetone treatment and the recovery rate was assessed by histochemical staining, electron microscopic examination and lipid analysis. RESULTS: Although the transepidermal water loss recovered completely by 48 hours in both of the acute models, acetone treated samples seem to have on over-all better recovery rate than tape-stripped samples. The return of barrier function to normal in both tape-stripped and acetone-treated skin was accompanied by a comparable return of normal nile red and ruthenium tetroxide staining. The amount of lipid in stratum corneum paralleled both the return of barrier function towards normal and the extent of prior damage to the barrier in acetone treated skin, yet, the lipid synthesis in tape-stripped skin showed a slower return of lipid content. CONCLUSION: The difference in the recovery rate of the two acute models may be due to the fact that acetone mainly extracts intercellular lipids, whereas, tape-stripping has a prolonged effect by removal of comeocyte in addition to the intercellular lipids. This shows the importance of comeocytes as well as the intercellular lipid bilayer in the recovery of normal barrier function.
Acetone* ; Animals ; Extracellular Space ; Lipid Bilayers ; Mice ; Mice, Hairless ; Permeability ; Ruthenium ; Skin ; Water