Objective To observe the effects of carbachol(a cholinergic agent)on gastric emptying and gastric blood flow in resuscitation of early shock with oral administration of glucose-electrolyte solution(GES)in scalded rats.Methods Seventy-eight male Wistar rats were randomly assigned into five groups:shame scald(n=6),scald without fluid resuscitation(n=18),scald resuscitated with oral GES alone(n=18),scald resuscitated with oral carbachol alone(CAL,n=18),and scald resuscitated with oral carbachol plus GES(GES/CAL,n=18).About 35% TBSA scalded injury on back of rats was produced with boiling water(100℃,15s)in the latter four groups.GES(2ml/kg,which is equivalent to half volume of fluid infusion in first 24 hour according to Parkland' formula)was given twice in two-hour intervals by gavage beginning from 30min after the injury in GES and GES/CAL group.Carbachol(60?g/kg)was gavaged 30min after the injury in CAL and GES/CAL group.The gastric emptying rate was determined by phenol red emptying method and gastric blood flow was measured with laser Doppler at 2h,4h and 6h after the scald injury.Results The gastric emptying was obviously delayed and gastric blood flow was significantly reduced in scald animals compared with those in sham group(P

Objective Patients with knee osteoarthritis undergoing total knee arthroplasty may have a different degree of pain during the perioperative period. This will not only bring a lot of adverse effects to the patients,and directly affect the early postoperative functional exercise and rehabilitation of the knee joint. At present,the commonly methods used to relieve the pain after TKA are:patient con-trolled Intravenous analgesia(PCIA)、patient controlled epidural analgesia( PCEA)、continuous femoral nerve block analgesia(CFNB)、joint peripheral injection analgesia and some methods without using medi-cine. In this paper,the analgesia methods used during the perioperative period of TKA and the latest de-velopment are reviewed.

Objective To investigate the pollution condition and concentration variability of TVOC in different time after the decoration finished. Methods 57 newly decorated houses were collected in two districts in Guiyang and TVOC monitoring was conducted for 6 months. Results At the first monitoring time, the content range of TVOC was 0.532-23.560 mg/m3 and the median was 2.573 mg/m3. The content range of high, middle and low concentration after determination was 5.520-23.560 mg/m3, 2.004-4.993 mg/m3 and 0.532-1.905 mg/m3 respectively and the median was 10.150, 2.320, 1.074 mg/m3 respectively. 147 days after the decoration the concentration decreased to 0.6 mg/m3. Conclusion The pollution of TVOC in the newly decorated houses is severe. 147 days after the decoration, the concentration of TVOC may decrease and reaches to under the standard limit.

Objective To follow up the intelligence and physical development of 156 infants borne from PIH mothers; to study the measures to improve their ntellectual development and provide basis for the management fo the infant from PIH partiuents. Methods By using the physical intelligential development investigation table we followed up the intellectual and physical development of the infants in PIH group and the normal group at the age of one, two and three years old. Results There were significant differences between PIH gr development ( P

BACKGROUND:Longitudinal study of changes in obesity is an important method to explore the etiology, which can provide scientific basis for preventing and control ing obesity.
OBJECTIVE:To investigate the effect of age, observation period and birth cohort on the obesity prevalence of adults in Jiangsu province through the age-period-cohort analysis.
METHODS:20-69-year-old adults in Jiangsu province were col ected as the research objects. The stratified cluster sampling method was used to col ect the obese data in 2000-2010, and analyzed with SAS software. RESULTS AND CONCLUSION:Obesity prevalence of 1946-1950 birth cohort to 1976-1980 birth cohort was gradual y increased (P<0.05) from 2000 to 2010. Obesity prevalence from 1931-1935 birth cohort to 1941-1945 birth cohort was not significantly increased (P>0.05). With the increasing age in each age group of over 25 years old, the risk of obesity was increased gradual y. There were significant differences in the odds ratios between the baseline groups of 20-25 years old and the age groups of over 25 years (P<0.05). Compared with the 1995-1999 birth cohort, the other periods had a slight influence on the obesity prevalence (P>0.05). Compared with 1976-1980 birth cohort, there were no significant differences in the risks of obesity of the birth cohorts after 1951-1955 (P>0.05). But the risk of obesity from 1946-1950 birth cohort to 1931-1935 birth cohort was gradual y significant since the 2000;obesity risks of those born in the different times were different;rural area wil be the key area than 45 years old.

Objective: To summarize the short-term clinical experience of minimally invasive direct cardiac surgery (MIDCS) with right anterolateral thoracotomy incision by closed cardiopulmonary bypass. Methods: A total of 42 patients received MIDCS in our hospital from 2013-09 to 2015-05 were summarized. There were 18 male and 24 female patients including 16 with atrial septal defect (ASD) repair, 4 with ventricular septal defect (VSD) repair, 16 with mitral valve replacement (MVR), 1 with mitral valve plasty (MVP) and 5 with aortic valve replacement (AVR). Direct cardiac surgery was performed by cardiopulmonary bypass through femoral artery-vein and right jugular vein annulations. A right anterolateral thoracotomy incision (length 3-5 cm) was made to enter the chest and complete the operation. Results: All 42 patients received successful operation, no peri-operative or early post-operative death, no incision infection occurred. Cardiopulmonary bypass time was [98-142 (122.4 ± 23.7) min], aortic cross-clamp time [0-118 (48.3 ± 26.2) min]. Post-operative mechanical ventilation time was [8-76 (17.4±13.1) h], intensive care unit stay time [45-124, (54.6 ± 32.6) h], hospital stay time [6-12, (8.2 ± 1.3) d]. Incision length was [3-7, (4.8 ± 1.5) cm], the draining volume at the 1st post-operative day was (356.9 ± 283.8) ml and there were 27 (64.3%) patients without transfusion. Conclusion: The short-term outcomes for MIDCS were good, it with superior safety, broad application range with minimal invasion and less complication.

Objective: To prepare and optimize the formulation of intranasal thermo-sensitive gel of Zhi Xiong San and to evaluate its in vitro release mechanism and nasal mucosa permeability. Methods: The formulations of poloxamer thermo-sensitive gel were optimized by a central composite design-response surface method and its in vitro release mechanism and nasal mucosa permeability were evaluated by Franz diffusion chambers. Results: The optimal formulation was Poloxamer 407 (P407) 20% and Poloxamer 188 (P188) 6.5%. Imperatorin was released from the thermo-sensitive gels approximately with a zero-order mechanism, while ferulic acid with a Higuchi model. The formulation demonstrated the enhancement of nasal mucosa permeability. Conclusion: The optimal formulation provides a basis for the development of new administration routes and dosage forms of Zhi Xiong San.

The rapid development of the globalization process has brought global health problems and made global health a hotspot in the world. China’s “One Belt and One Road” initiative has strengthened economic and trade exchanges between China and Asia, Africa, Europe, and has also increased health risks such as the spread of infectious diseases, disease spectrum, and lifestyle changes, posing challenges to the development of global health in China. Based on the history of global health, this paper made a brief review of the current status and future development of global health research. It pointed out that China’s global health research started late and had many shortcomings. In the context of the One Belt And One Road initiative, We should seize opportunities and meet challenges to contribute to the construction of "Healthy China" and the promotion to global health.

Animals ; Arrestins ; metabolism ; Hypoxia ; metabolism ; Male ; Prefrontal Cortex ; metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled ; metabolism ; beta-Arrestin 1 ; beta-Arrestins

Objective To study the effects on electroporation of Qingfengteng cataplasma transdermal absorption and describe the characteristics of animal pharmacokinetics of it.Methods Two-chamber diffusion cell was used and the plasma drug concentration was determined by HPLC.The application of AIC theory to analysis of the compartmentally based model of sinomenine transdermal delivery by electroporation.Results The Cmax,Ka,and AUC0→∞ of electroporation was larger than those of passive diffusion;t1/2(Ka)and tmax of electroporation were reduced compared with passive diffusion.The drug concentration-curve equation were C=2.884?(e-0.056 t-e-0.232 t)and C=2.512?(e-0.058 t-e-0.149 t)for electroporation and passive diffusion,respectively.Conclusion The change of in vivo drug concentration of Qingfengteng calaplasma transdermal absorption by electroporation could be analized in accordance with mammillary one-compartment open model.The etrectroporation technology could sharply enhance the bioavalibility compared with the passive diffusion.