The genus Michelia, belonging to family Magnoliaceae, consists of about 80 plant species mainly distributed in South Asian countries. The plants of this genus have been traditionally used in curing various diseases like fever, colic, leprosy, eye disorders, inflammation, antidote for scorpion, etc. Ninety-four compounds isolated from nine species of the genus Michelia like sesquiterpenes, steroids, flavonoids, aporphines, phenols, esters, benzenoid and alkaloids have antibacterial, anticancer and antiplasmodial activities. This review presents first time detailed information on chemical and biological properties of constituents isolated from the genus Michelia.