1.Frequency of Serious Adverse Skin Reactions Caused by Continuous Subcutaneous Administration of Psychotropic Drugs
Ritsuko Yabuki ; Takayuki Hisanaga ; Daisuke Kiuchi ; Miho Shimokawa ; Katsuya Abe ; Takahiro Otsuka ; Ayako Sakurai ; Satoko Suda ; Yasuo Shima
Palliative Care Research 2016;11(1):123-127
Continuous subcutaneous injections of medication are effective in controlling symptoms of the terminal stage of cancer. Chlorpromazine and levomepromazine occasionally cause skin irritation. We examined all patients who underwent continuous subcutaneous administration of psychotropic drugs (chlorpromazine, levomepromazine, midazolam) at the palliative care unit of our hospital from April 2010 to March 2013, the frequency of adverse skin reactions of Common Terminology Criteria for Adverse Events (CTCAE) v4.0 grade 3 or above. Of the 603 hospitalized patients, 389 (64.5%) underwent continuous subcutaneous administration of one of the three drugs. The frequency of grade 3 or above (ulceration or necrosis) adverse skin reactions was 4 out of 345 chlorpromazine cases (1.2%; 95% CI: 0.0-2.3%), 2 out of 90 levomepromazine cases (2.2%; 95% CI: −0.8-5.2%), and 0 out of 210 midazolam cases (0.0%; 95% CI: 0.0-0.0%). The frequency of serious adverse skin reactions caused by continuous subcutaneous administration of psychotropic drugs was low, suggesting that this treatment is relatively safe for the skin.
2.The Strategy of Pain Management for the Individuals with Spinal Cord Injury
Satoko Matsumoto HARMON ; Kota SUDA ; Miki KOMATSU ; Takashi ONISHI ; Takamasa WATANABE ; Mitsuru ASUKAI ; Yasuaki TOJO ; Yoshihiro UTSUNOMIYA ; Akio MINAMI
The Japanese Journal of Rehabilitation Medicine 2019;56(7):547-551