Paragangliomas are rare neuroendocrine tumors that frequently arise in the organ of Zuckerkandl (OZ). Surgical resection remains the cornerstone of treatment. Although vascular resection and reconstruction have been reported in a few cases, no prior reports have documented the simultaneous resection of both the aorta and inferior vena cava (IVC), along with their bifurcation. We present the case of a 50-year-old man with a large paraganglioma of the OZ, successfully managed through combined resection of the aorta, IVC, their bifurcation, and the psoas muscle. Dacron Y-grafts were used to reconstruct both the aorta and IVC. This case underscores the importance of detailed anatomical knowledge of major vessels, meticulous vascular control, and the technical intricacies of vascular reconstruction. We emphasize the significance of comprehensive perioperative management and provide a literature review on en bloc vascular resection for paraganglioma, offering insights into current surgical practices and outcomes.

Paragangliomas are rare neuroendocrine tumors that frequently arise in the organ of Zuckerkandl (OZ). Surgical resection remains the cornerstone of treatment. Although vascular resection and reconstruction have been reported in a few cases, no prior reports have documented the simultaneous resection of both the aorta and inferior vena cava (IVC), along with their bifurcation. We present the case of a 50-year-old man with a large paraganglioma of the OZ, successfully managed through combined resection of the aorta, IVC, their bifurcation, and the psoas muscle. Dacron Y-grafts were used to reconstruct both the aorta and IVC. This case underscores the importance of detailed anatomical knowledge of major vessels, meticulous vascular control, and the technical intricacies of vascular reconstruction. We emphasize the significance of comprehensive perioperative management and provide a literature review on en bloc vascular resection for paraganglioma, offering insights into current surgical practices and outcomes.

Paragangliomas are rare neuroendocrine tumors that frequently arise in the organ of Zuckerkandl (OZ). Surgical resection remains the cornerstone of treatment. Although vascular resection and reconstruction have been reported in a few cases, no prior reports have documented the simultaneous resection of both the aorta and inferior vena cava (IVC), along with their bifurcation. We present the case of a 50-year-old man with a large paraganglioma of the OZ, successfully managed through combined resection of the aorta, IVC, their bifurcation, and the psoas muscle. Dacron Y-grafts were used to reconstruct both the aorta and IVC. This case underscores the importance of detailed anatomical knowledge of major vessels, meticulous vascular control, and the technical intricacies of vascular reconstruction. We emphasize the significance of comprehensive perioperative management and provide a literature review on en bloc vascular resection for paraganglioma, offering insights into current surgical practices and outcomes.

Objectives: Geriatric maxillofacial trauma (GMT) is not an uncommon entity in maxillofacial surgery practice. The aim of the study was to document the experience with GMT cases in a single private dental college and hospital in an effort to uncover the etiology, prevalence, fracture sites, and various types of treatment in GMT. Materials and Methods: This was a retrospective study conducted at Saveetha Dental College and Hospital in Chennai. Data from patients diag-nosed with maxillofacial trauma between January 2019 and December 2023 were retrieved from hospital records, and those aged ≥60 years wereincluded in the study. Patients’ basic demographic details and the prevalence, etiology, fracture sites, and various treatments of GMT were recorded and analyzed. The collected data were entered into a structured database and analyzed using IBM SPSS Statistics ver. 23.0 (IBM). Results: A total of 867 cases were screened, and 37 (4.04%) GMT patients were finally included in the study. The mean age of the study population was 65±5 years, and there were six females and 31 males. A ground-level fall was the common etiology (n=17), and the most common site of fracture was the mandible (n=15). Open reduction and internal fixation (ORIF) was the most common treatment modality (n=24) among included cases. Conclusion Although the prevalence of GMT was low, ground-level falls were a common reason for trauma; hence, geriatric patients require comprehensive care in home and outdoor settings. Enhanced anesthetic and surgical techniques have made ORIF a suitable treatment approach in the present era.

Objectives: Geriatric maxillofacial trauma (GMT) is not an uncommon entity in maxillofacial surgery practice. The aim of the study was to document the experience with GMT cases in a single private dental college and hospital in an effort to uncover the etiology, prevalence, fracture sites, and various types of treatment in GMT. Materials and Methods: This was a retrospective study conducted at Saveetha Dental College and Hospital in Chennai. Data from patients diag-nosed with maxillofacial trauma between January 2019 and December 2023 were retrieved from hospital records, and those aged ≥60 years wereincluded in the study. Patients’ basic demographic details and the prevalence, etiology, fracture sites, and various treatments of GMT were recorded and analyzed. The collected data were entered into a structured database and analyzed using IBM SPSS Statistics ver. 23.0 (IBM). Results: A total of 867 cases were screened, and 37 (4.04%) GMT patients were finally included in the study. The mean age of the study population was 65±5 years, and there were six females and 31 males. A ground-level fall was the common etiology (n=17), and the most common site of fracture was the mandible (n=15). Open reduction and internal fixation (ORIF) was the most common treatment modality (n=24) among included cases. Conclusion Although the prevalence of GMT was low, ground-level falls were a common reason for trauma; hence, geriatric patients require comprehensive care in home and outdoor settings. Enhanced anesthetic and surgical techniques have made ORIF a suitable treatment approach in the present era.

Paragangliomas are rare neuroendocrine tumors that frequently arise in the organ of Zuckerkandl (OZ). Surgical resection remains the cornerstone of treatment. Although vascular resection and reconstruction have been reported in a few cases, no prior reports have documented the simultaneous resection of both the aorta and inferior vena cava (IVC), along with their bifurcation. We present the case of a 50-year-old man with a large paraganglioma of the OZ, successfully managed through combined resection of the aorta, IVC, their bifurcation, and the psoas muscle. Dacron Y-grafts were used to reconstruct both the aorta and IVC. This case underscores the importance of detailed anatomical knowledge of major vessels, meticulous vascular control, and the technical intricacies of vascular reconstruction. We emphasize the significance of comprehensive perioperative management and provide a literature review on en bloc vascular resection for paraganglioma, offering insights into current surgical practices and outcomes.

Objectives: Geriatric maxillofacial trauma (GMT) is not an uncommon entity in maxillofacial surgery practice. The aim of the study was to document the experience with GMT cases in a single private dental college and hospital in an effort to uncover the etiology, prevalence, fracture sites, and various types of treatment in GMT. Materials and Methods: This was a retrospective study conducted at Saveetha Dental College and Hospital in Chennai. Data from patients diag-nosed with maxillofacial trauma between January 2019 and December 2023 were retrieved from hospital records, and those aged ≥60 years wereincluded in the study. Patients’ basic demographic details and the prevalence, etiology, fracture sites, and various treatments of GMT were recorded and analyzed. The collected data were entered into a structured database and analyzed using IBM SPSS Statistics ver. 23.0 (IBM). Results: A total of 867 cases were screened, and 37 (4.04%) GMT patients were finally included in the study. The mean age of the study population was 65±5 years, and there were six females and 31 males. A ground-level fall was the common etiology (n=17), and the most common site of fracture was the mandible (n=15). Open reduction and internal fixation (ORIF) was the most common treatment modality (n=24) among included cases. Conclusion Although the prevalence of GMT was low, ground-level falls were a common reason for trauma; hence, geriatric patients require comprehensive care in home and outdoor settings. Enhanced anesthetic and surgical techniques have made ORIF a suitable treatment approach in the present era.

Paragangliomas are rare neuroendocrine tumors that frequently arise in the organ of Zuckerkandl (OZ). Surgical resection remains the cornerstone of treatment. Although vascular resection and reconstruction have been reported in a few cases, no prior reports have documented the simultaneous resection of both the aorta and inferior vena cava (IVC), along with their bifurcation. We present the case of a 50-year-old man with a large paraganglioma of the OZ, successfully managed through combined resection of the aorta, IVC, their bifurcation, and the psoas muscle. Dacron Y-grafts were used to reconstruct both the aorta and IVC. This case underscores the importance of detailed anatomical knowledge of major vessels, meticulous vascular control, and the technical intricacies of vascular reconstruction. We emphasize the significance of comprehensive perioperative management and provide a literature review on en bloc vascular resection for paraganglioma, offering insights into current surgical practices and outcomes.

Itolizumab downregulates the synthesis of proinflammatory cytokines and adhesion molecules by inhibiting CD6 leading to lower levels of interferon-γ, interleukin-6, and tumor necrotic factor-α and reduced T-cell infiltration at inflammatory sites. This study aims to compare the effects of tocilizumab and itolizumab in the management of severe coronavirus disease 2019 (COVID-19). Methods: The study population was adults (>18 years) with severe COVID-19 pneumonia admitted to the intensive care unit receiving either tocilizumab or itolizumab during their stay. The primary outcome was clinical improvement (CI), defined as a two-point reduction on a seven-point ordinal scale in the status of the patient from initiating the drug or live discharge. The secondary outcomes were time until CI, improvement in PO2 /FiO2 ratio, best PO2 /FiO2 ratio, need for mechanical ventilation after administration of study drugs, time to discharge, and survival days. Results: Of the 126 patients included in the study, 92 received tocilizumab and 34 received itolizumab. CI was seen in 46.7% and 61.7% of the patients in the tocilizumab and itolizumab groups, respectively and was not statistically significant (P=0.134). The PO2 /FiO2 ratio was significantly better with itolizumab compared to tocilizumab (median [interquartile range]: 315 [200–380] vs. 250 [150–350], P=0.043). The incidence of serious adverse events due to the study drugs was significantly higher with itolizumab compared to tocilizumab (14.7% vs. 3.3%, P=0.032). Conclusions: The CI with itolizumab is similar to tocilizumab. Better oxygenation can be achieved with itolizumab and it can be a substitute for tocilizumab in managing severe COVID-19.

Itolizumab downregulates the synthesis of proinflammatory cytokines and adhesion molecules by inhibiting CD6 leading to lower levels of interferon-γ, interleukin-6, and tumor necrotic factor-α and reduced T-cell infiltration at inflammatory sites. This study aims to compare the effects of tocilizumab and itolizumab in the management of severe coronavirus disease 2019 (COVID-19). Methods: The study population was adults (>18 years) with severe COVID-19 pneumonia admitted to the intensive care unit receiving either tocilizumab or itolizumab during their stay. The primary outcome was clinical improvement (CI), defined as a two-point reduction on a seven-point ordinal scale in the status of the patient from initiating the drug or live discharge. The secondary outcomes were time until CI, improvement in PO2 /FiO2 ratio, best PO2 /FiO2 ratio, need for mechanical ventilation after administration of study drugs, time to discharge, and survival days. Results: Of the 126 patients included in the study, 92 received tocilizumab and 34 received itolizumab. CI was seen in 46.7% and 61.7% of the patients in the tocilizumab and itolizumab groups, respectively and was not statistically significant (P=0.134). The PO2 /FiO2 ratio was significantly better with itolizumab compared to tocilizumab (median [interquartile range]: 315 [200–380] vs. 250 [150–350], P=0.043). The incidence of serious adverse events due to the study drugs was significantly higher with itolizumab compared to tocilizumab (14.7% vs. 3.3%, P=0.032). Conclusions: The CI with itolizumab is similar to tocilizumab. Better oxygenation can be achieved with itolizumab and it can be a substitute for tocilizumab in managing severe COVID-19.