1.Study on survival time of breast cancer patients
Sarantsetseg G ; Tuvshingerel S
Mongolian Medical Sciences 2015;171(1):21-24
INTRODUCTION:Breast cancer is one of the most common cancers in the world. According to the WHO report, over 14.1million new cases were registered every year. 6% of all cancers of Mongolian women were indicated asa breast cancer. This is the 2.5% of cancer cases of whole Mongolian population.GOAL:Identify observed 5 year survival rate and mean of survived time of patients with breast cancers inMongolian population, and some risk factors of survival.MATERIALS AND METHODS:The study design was retrospective and a total of 195 patients were selected which are registered bybreast cancer in National Cancer Registry of Mongolia, 2007-2008 years. Average of survival timecalculated by median and mean, observed 1, 3, 5 year survival rate calculated by percent. Data analyseswere performed using SPSS 19.0 software.RESULT:Totally 195 people involved in research, 5 year after diagnosed 59 (30.3%) people died from cancer, 136(69.7%) people was alive.Breast cancer patients observed 1, 3, 5 year survival rate was correlated to age group, level of education,stage of diagnosis and get involved cancer treatment.Breast (Wald (3) =26.30, P<0.0001) cancer patients survival was correlated to stage of diagnosis and getinvolved cancer treatment.CONCLUSION:1. Mean of survived time of patients with breast cancer was 50.4 months and observed 5 year survivalrate 69.7%.2. Breast cancer patient’s survival was correlated to age group and level of education.3. Breast cancer patient’s survival was correlated to stage of diagnosis and get involved cancertreatment.
2.Mode of energy and metabolism which related to three state line systems of membrane-redoxy potentials and rlung, mkris, badgan symbolic coded
Narantsetseg B ; Narantsetseg J, Sarantsetseg B ; Khishigjargal S ; Ambaga M
Mongolian Medical Sciences 2013;166(4):57-62
Background. This study is to determine mode of metabolism on triple collaboration bridges of traditional medicine, modern medicine and NCM.Goal. To determine membrane redoxy potentials three line involves important regulation factors on mode of metabolism which relationship connected with rlung, mkris, and badgan symbolic code.Materials and Methods. Only 81 healthy individuals were involved in the study. Proton leak was determined by quantity rate of MDA in cell membrane and membrane resistance, proton conductance was determined by serum and urine oxidase activity.Results. The table 1 shows quantity rate of membrane resistance was decreased 1.08-1.52 fold, HDL content was decreased, and however LDL was increased. This result is to manifest low proton leak which means this type is likely belonged to badgan symbolic code with qualities cold fatty, earth, water. The table 2 shows serum and urine oxidize activity 2.22-6.1 fold was increased, HDL content was increased; UCP-3 gene activity relatively was increased. This result is to manifest highproton conductance which means this type is likely belonged to mkris symbolic code with qualities hot fatty, fire.Conclusions:1. Individuals with high proton leak and slow proton conductance had serum and urine oxidize activity were weak, therefore there are visceral and subcutaneous fat were low.2. Individuals with medium proton leak and high proton conductance had serum and urine oxidize activity were high, therefore there are visceral was low and subcutaneous fat was high.3. Individuals with weak proton leak and medium proton conductance had serum and urine oxidize activity were medium, therefore there are visceral was high and subcutaneous fat was low.
3. DIAGNOSTIC TREATMENT SITUATION OF BIPOLAR DISORDER
Gantsetseg T ; Khishigsuren Z ; Odongerel S ; Minjmaa R ; Nyamtsetseg J ; Sarantsetseg T ; Sugarmaa SH ; Gantulga J ; Tuya N
Innovation 2015;9(1):28-33
WHO informed that across world an average of 565 young people aged 10 to 29 die every day through interpersonal violence. Some studies mentioned that anxiety was most frequently occurred as one of the psychological onsequences among victims of child abuse. Recent research on effects of adverse early life experiences on central nervous system as stress systems (hypothalamus-pituitary-adrenal axis-HPA) has provided a greater understanding of the link between childhood abuse and susceptibility to anxiety disorder. Therefore, this research was done to study anxiety among abused adolescents, some physical parameters and level of cortisol in saliva.Total number of participants were 149 children aged between 11-16 years (number cases were 53, matched control subjects were 96). The Spence Children’s Anxiety Scale (SCAS; Spence, 1997) is a 38-item self-report uestionnaire that assesses multiple symptoms of childhood anxiety isorders based on current diagnostic criteria. All participants were measured the cortisol in the saliva by Cortisol ELISA kit, Sigma, USA. Average age of all subjects in the study was 13.52±1.57 and 102 of all subjects were female and 47 were male. All anxiety symptoms of case group was statistically significance higher (p<0.01) than control group. The average amount of salivary cortisol of case group was (21.3±8.1 ng/ml) statistically significantly lower (p<0.01) than average amount of control group (31.56±16.9 ng/ml). Anxiety was more frequently occurred among abused children and blunted cortisol responses might indicate a level of impaired HPA functioning that could constitute a vulnerability to psychopathology with exposure to anxiety.
4. ASSESSMENT OF EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY (ESWL) THERAPEUTIC EFFICIENCY IN MONGOLIA
Sarantsetseg N ; Nyambayar N ; Erdenesaikhan M ; Javkhlantugs D ; Myagmarsuren P ; Sodgerel B ; Ganbold G ; Ariunaa S ; Bayan-Undur D
Journal of Surgery 2016;20(2):42-45
Introduction: Extracorporeal shockwave lithotripsy (ESWL) revolutionizedthe treatment of urolithiasis and graduallybecame the favorite treatment option sothat today it is considered to be the first lineof treatment for patients with urolithiasis.The purpose of this study was assessment oftherapeutic efficacy, complications of ESWLin urolithiasis in Mongolia.Material and methods: A total of46 patients harboring renal and ureteralstones underwent ESWL between March2016 and September 2016 at First CentralHospital of Mongolia. Karl Storz ModulithSLK electromagnetic machines were usedto impart shock waves. All collected stonefragments sent for biochemical analysis.Results: A total of 46 patients 23 weremales (50%). Patients were mean age of34. The stone size distribution was 0.5cmto 3.1cm. The average treatment time wasranging from 75-110 minutes. The averagenumber of shock waves per treatmentwas 3172±378 (range 1500-4000). Theoverall success rate was 75.73%. All calculidisintegrated satisfactorily except for 3stones, which is located lower 1/3rd ofureter. Stone composition analysis proved tobe composed entirely or predominantly ofcalcium oxalate monohydrate. These patientsrequired to have ureterolithoextraction. Calculicomposition for remaining patients 12 werecalcium oxalate monohydrate, 17 calciumoxalate dehydrate, 6 uric acid and 1 struvite.Complications were mostly minor and rare.Most of the patients (90.7%) developedmacroscopic hematuria after treatment; fewpatients developed mild bruising at the entryand exit sites of the shockwaves on the bodywall. Severe complications such as renalhematoma and steinstrasse were diagnosedfor one patient each and their managementwas non-surgical.Conclusion: ESWL is therefore the firstline treatment for urolithiasis with stonesize smaller than 2cm. It has an efficiencyrate above 75, low procedure time, highsafety and good tolerability and minimalcomplication.
5.Study of the Antischemin’s effect on immune response intensity
Oyuntsetseg S ; Ambaga M ; Sarantsetseg B ; Khishigjargal S
Mongolian Medical Sciences 2019;190(4):48-51
Background:
The immune response has become the basic use of today’s medical and biological sciences
understanding, definition and realization when first introduced into the cognitive level with new theory
of nine step closed cycle of protons related to membrane potentials three linear and s-NCM. Medicinal
preparations for the immune system derived from traditional herbs have rarely been used therefore,
we aim to determine the boost-reduction of immune response with preparation Antischemin with
ingredients of Gingko biloba, Astragalus membranaceus and Scutellaria baicalensis.
Materials and Methods:
This study was carried out on the innovation-research bio-modeling laboratory of the “New Medicine
Medical University”. Sheep blood was taken in heparin tube and centrifuged for 10min with speed
of 2000rpm and plasma was isolated. Blood components were washed with physiological solution
3-4 times and 10% blood red cell suspension was prepared. Prepared 0.2ml of 10% sheep red cell
suspension was injected to mice tail vein to create immune response model (N.K. Jerne and Nordin
(1963)). IL-4 (pg), antibody titre SRBC-IgM(ng/mL), and hemagglutinin titre (%) was measured
with ELISA kit and compared with control group. Comparing group animals used Salimon 1 ml/kg,
Dexamethasone 1 mg/kg orally. The study was conducted in accordance with the approval of Ethics
Review Committee of Ministry of Health (November 02, 2018 and approval number 10, №1).
Result :
In addition, comparing mice which used Antischemin 100 mg/kg orally with sheep blood injected
group at day 5, IL-4 level increased by 12.11%, but conclution of antibodies against sheep blood-IgM concentration decreased by 28.7%, and hemagglutinin titre decreased by 27.5%, meaning we
observed that the preparation can suppress immune response.
Сonclusions
Antischemin preparation meaning observed can suppress immune response.
6.THE RELATIONSHIP BETWEEN ATHEROGENIC INDEX OF PLASMA AND RISKS OF CARDIOVASCULAR DISEASE
Rinchyenkhand M ; Tungalag Sh ; Sarantsetseg S ; Odgerel N ; Burmaa B ; Tsolmon U
Innovation 2017;11(4):27-31
BACKGROUND: Cardiovascular diseases (CVDs) account for >17 million deaths globally each year and this figure is expected to grow to 23.6 million by 2030. According to the WHO report, one-third of ischemic heart disease is attributable to high cholesterol. There have been some claims that the atherogenic index of plasma (AIP), which is the logarithmic transformation of the just-mentioned ratio (TG/HDL-C), could be used as a significant predictor of atherosclerosis, and CVD as well. Thus, we aimed to study the relationship between AIP and cardiovascular risk factors.
METHODS: The cross-sectional hospital based study was conducted including 117 participants aged between 40-72 years old without cardiovascular symptoms were recruited from Second General Hospital. After filled consent form, participants’ habits of smoking, alcohol usage, obesity, arterial hypertension and sedentary lifestyle were assessed through a structured questionnaire and physical examination. By using fully automated open-system analyzer, determinations of total cholesterol, triglycerides, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) three times and glucose twice were performed simultaneously and then their averages were calculated. At least one abnormal lipid level was considered as “dyslipidemia”. The atherogenic index of plasma (AIP) was calculated as the logarithmically transformed ratio of molar concentrations of TG to HDL-C. Statistical analysis was performed using SPSS 22.
RESULTS: Of total 117 participants ranging 40-72 years old, 45.3% were male and 54.7% were female with mean age 53.6±0.79. Regarding cardiovascular risk factors, 63.8% were physically inactive, 32.48% were smokers, 47% were alcohol user, 48% were hypertensive, and 18.26% were diabetic. The mean values plus standard error of lipid components were 195.5±6.09 mg/dL in cholesterol, 181.25±27.36 mg/dL in triglycerides, 60.6±1.39 mg/dL in HDL-C, 138.5±3.74 mg/dL in LDL-C, 6.27±0.26 mmol/L in fasting glucose. The dyslipidemia was detected in 54.7% of total participants and mean level of AIP was 0.33±0.03 (min=-0.52; max=1.51). The mean levels of 10 year and lifetime risk were 6.25±0.63% (min=0.2; max=33.5) and 43±1.53% (min=7.5; max=69), respectively. AIP had weak correlations with gender, smoking, anti-hypertensive drug usage, aspirin usage, 10 year and lifetime risks of CVD, hypertension, fasting glucose, body mass index, and dyslipidemia (0.2