INTRODUCTION:Breast cancer is one of the most common cancers in the world. According to the WHO report, over 14.1million new cases were registered every year. 6% of all cancers of Mongolian women were indicated asa breast cancer. This is the 2.5% of cancer cases of whole Mongolian population.GOAL:Identify observed 5 year survival rate and mean of survived time of patients with breast cancers inMongolian population, and some risk factors of survival.MATERIALS AND METHODS:The study design was retrospective and a total of 195 patients were selected which are registered bybreast cancer in National Cancer Registry of Mongolia, 2007-2008 years. Average of survival timecalculated by median and mean, observed 1, 3, 5 year survival rate calculated by percent. Data analyseswere performed using SPSS 19.0 software.RESULT:Totally 195 people involved in research, 5 year after diagnosed 59 (30.3%) people died from cancer, 136(69.7%) people was alive.Breast cancer patients observed 1, 3, 5 year survival rate was correlated to age group, level of education,stage of diagnosis and get involved cancer treatment.Breast (Wald (3) =26.30, P<0.0001) cancer patients survival was correlated to stage of diagnosis and getinvolved cancer treatment.CONCLUSION:1. Mean of survived time of patients with breast cancer was 50.4 months and observed 5 year survivalrate 69.7%.2. Breast cancer patient’s survival was correlated to age group and level of education.3. Breast cancer patient’s survival was correlated to stage of diagnosis and get involved cancertreatment.

Background. This study is to determine mode of metabolism on triple collaboration bridges of traditional medicine, modern medicine and NCM.Goal. To determine membrane redoxy potentials three line involves important regulation factors on mode of metabolism which relationship connected with rlung, mkris, and badgan symbolic code.Materials and Methods. Only 81 healthy individuals were involved in the study. Proton leak was determined by quantity rate of MDA in cell membrane and membrane resistance, proton conductance was determined by serum and urine oxidase activity.Results. The table 1 shows quantity rate of membrane resistance was decreased 1.08-1.52 fold, HDL content was decreased, and however LDL was increased. This result is to manifest low proton leak which means this type is likely belonged to badgan symbolic code with qualities cold fatty, earth, water. The table 2 shows serum and urine oxidize activity 2.22-6.1 fold was increased, HDL content was increased; UCP-3 gene activity relatively was increased. This result is to manifest highproton conductance which means this type is likely belonged to mkris symbolic code with qualities hot fatty, fire.Conclusions:1. Individuals with high proton leak and slow proton conductance had serum and urine oxidize activity were weak, therefore there are visceral and subcutaneous fat were low.2. Individuals with medium proton leak and high proton conductance had serum and urine oxidize activity were high, therefore there are visceral was low and subcutaneous fat was high.3. Individuals with weak proton leak and medium proton conductance had serum and urine oxidize activity were medium, therefore there are visceral was high and subcutaneous fat was low.

WHO informed that across world an average of 565 young people aged 10 to 29 die every day through interpersonal violence. Some studies mentioned that anxiety was most frequently occurred as one of the psychological onsequences among victims of child abuse. Recent research on effects of adverse early life experiences on central nervous system as stress systems (hypothalamus-pituitary-adrenal axis-HPA) has provided a greater understanding of the link between childhood abuse and susceptibility to anxiety disorder. Therefore, this research was done to study anxiety among abused adolescents, some physical parameters and level of cortisol in saliva.Total number of participants were 149 children aged between 11-16 years (number cases were 53, matched control subjects were 96). The Spence Children’s Anxiety Scale (SCAS; Spence, 1997) is a 38-item self-report uestionnaire that assesses multiple symptoms of childhood anxiety isorders based on current diagnostic criteria. All participants were measured the cortisol in the saliva by Cortisol ELISA kit, Sigma, USA. Average age of all subjects in the study was 13.52±1.57 and 102 of all subjects were female and 47 were male. All anxiety symptoms of case group was statistically significance higher (p<0.01) than control group. The average amount of salivary cortisol of case group was (21.3±8.1 ng/ml) statistically significantly lower (p<0.01) than average amount of control group (31.56±16.9 ng/ml). Anxiety was more frequently occurred among abused children and blunted cortisol responses might indicate a level of impaired HPA functioning that could constitute a vulnerability to psychopathology with exposure to anxiety.

Introduction: Extracorporeal shockwave lithotripsy (ESWL) revolutionizedthe treatment of urolithiasis and graduallybecame the favorite treatment option sothat today it is considered to be the first lineof treatment for patients with urolithiasis.The purpose of this study was assessment oftherapeutic efficacy, complications of ESWLin urolithiasis in Mongolia.Material and methods: A total of46 patients harboring renal and ureteralstones underwent ESWL between March2016 and September 2016 at First CentralHospital of Mongolia. Karl Storz ModulithSLK electromagnetic machines were usedto impart shock waves. All collected stonefragments sent for biochemical analysis.Results: A total of 46 patients 23 weremales (50%). Patients were mean age of34. The stone size distribution was 0.5cmto 3.1cm. The average treatment time wasranging from 75-110 minutes. The averagenumber of shock waves per treatmentwas 3172±378 (range 1500-4000). Theoverall success rate was 75.73%. All calculidisintegrated satisfactorily except for 3stones, which is located lower 1/3rd ofureter. Stone composition analysis proved tobe composed entirely or predominantly ofcalcium oxalate monohydrate. These patientsrequired to have ureterolithoextraction. Calculicomposition for remaining patients 12 werecalcium oxalate monohydrate, 17 calciumoxalate dehydrate, 6 uric acid and 1 struvite.Complications were mostly minor and rare.Most of the patients (90.7%) developedmacroscopic hematuria after treatment; fewpatients developed mild bruising at the entryand exit sites of the shockwaves on the bodywall. Severe complications such as renalhematoma and steinstrasse were diagnosedfor one patient each and their managementwas non-surgical.Conclusion: ESWL is therefore the firstline treatment for urolithiasis with stonesize smaller than 2cm. It has an efficiencyrate above 75, low procedure time, highsafety and good tolerability and minimalcomplication.

Considering the fact that it is becoming important to broaden the studies of herbal medicine with few side effects which can treat acute and chronic inflammations of the liver and biliary tract, liver cirrhosis and can prevent from transformation into cancer, we chose Saxifraga hirculus L as our study objective which has been used in liver and biliary disease treatments of Tibetan – Mongolian traditional medicine for many years. This study aims to study one of the species of the family Saxifrgaceaca, Saxifraga hirculus L’s liverprotective activity and effect on the liver and biliary tract diseases resulted from bile stasis, which frequently comes as an ingredient of compound prescription of the traditional medicine. 01/01 Study methods: Experimental pathological liver disease model was developed in total of 520 white rats and 80 white mice in 2 ways, Saxifraga hirculus L’s bile-forming and detoxifying function and effects on the detergent effect of bile, necrotic liver cell lysis and stability of lung cell surfactant were compared with the standard drugs such as Legalon and Cholasos and double proven by biochemical, pathohistologi and histochemical studies. 70% alcohol extract was prepared from the selected Saxifraga hirculus L, and dried and decocted extract was obtained from this and given to the experimental animals by oral intragastric tube in a dose of 100mg/kg. As the result of pathohistologi and histochemical study, necrosis and necrobiosis of liver cells were dominantly observed in CCl4 induced “toxic inflammation”, cholestatic syndrome and dysfunction of detoxication action were observed in Tetracycline Hydrochlorideinduced(druginduced)toxic inflammation in the experimental animals. The Saxifraga hirculus L’s most potent dose to treat and protect liver was estimated as 100mg/kg and this was 31 times lower than its LD50. In our study,Saxifraga hirculus L has possessed an anti-inflammatory effect on each stages of inflammation which is alteration, exudation and proliferation. In other hand, Saxifraga hirculus L increased the biliary secretion and excretion speed, protected from toxic detergent effect of bile acid, improved detoxication effect of the liver, protected from the necrotic cell lysis, showed an antioxidant and membrane stabilizing activity and these actions were compared with the standard medicines such as Legalon and Cholasos which in some cases, above mentioned effects were higher than these drugs. The hepatoprotective action of Saxifraga hirculus L may have been related to its contents such as compound flavonoids of the quercetin group, aglycone and bitter hyperoside. Also in the case of drug induced toxic hepatitis, Saxifraga hirculus L increased the amount of glycogen and nuclear DNA in the liver tissue by 22-24.5% compared to the control group and was proven by histochemical study.

During many hundred years, our foregathers have used various medicinal plants. It is important that we should do research based on scientigic that to abstract biological activity plants that is unknown still now, to seen sharp and harmgul features, to assort with physical and chemical features etc. Historically in the traditional medicine Rhododendron Adamsi.Rуhd, Rhododendron nivale Hook.fwere used as the preparation against different types of irritations as they have certain effects to increase immune, to cure lung desease, to decrease blood pressure. Within the frame of our research we screened the impact of Rhododendron Adamsi.Rуhd, Rhododendron nivale Hook.fonto hepatocyte’s membrane pereoxidation.

Background: The immune response has become the basic use of today’s medical and biological sciences understanding, definition and realization when first introduced into the cognitive level with new theory of nine step closed cycle of protons related to membrane potentials three linear and s-NCM. Medicinal preparations for the immune system derived from traditional herbs have rarely been used therefore, we aim to determine the boost-reduction of immune response with preparation Antischemin with ingredients of Gingko biloba, Astragalus membranaceus and Scutellaria baicalensis. Materials and Methods: This study was carried out on the innovation-research bio-modeling laboratory of the “New Medicine Medical University”. Sheep blood was taken in heparin tube and centrifuged for 10min with speed of 2000rpm and plasma was isolated. Blood components were washed with physiological solution 3-4 times and 10% blood red cell suspension was prepared. Prepared 0.2ml of 10% sheep red cell suspension was injected to mice tail vein to create immune response model (N.K. Jerne and Nordin (1963)). IL-4 (pg), antibody titre SRBC-IgM(ng/mL), and hemagglutinin titre (%) was measured with ELISA kit and compared with control group. Comparing group animals used Salimon 1 ml/kg, Dexamethasone 1 mg/kg orally. The study was conducted in accordance with the approval of Ethics Review Committee of Ministry of Health (November 02, 2018 and approval number 10, №1). Result : In addition, comparing mice which used Antischemin 100 mg/kg orally with sheep blood injected group at day 5, IL-4 level increased by 12.11%, but conclution of antibodies against sheep blood-IgM concentration decreased by 28.7%, and hemagglutinin titre decreased by 27.5%, meaning we observed that the preparation can suppress immune response. Сonclusions Antischemin preparation meaning observed can suppress immune response.

BACKGROUND: Cardiovascular diseases (CVDs) account for >17 million deaths globally each year and this figure is expected to grow to 23.6 million by 2030. According to the WHO report, one-third of ischemic heart disease is attributable to high cholesterol. There have been some claims that the atherogenic index of plasma (AIP), which is the logarithmic transformation of the just-mentioned ratio (TG/HDL-C), could be used as a significant predictor of atherosclerosis, and CVD as well. Thus, we aimed to study the relationship between AIP and cardiovascular risk factors. METHODS: The cross-sectional hospital based study was conducted including 117 participants aged between 40-72 years old without cardiovascular symptoms were recruited from Second General Hospital. After filled consent form, participants’ habits of smoking, alcohol usage, obesity, arterial hypertension and sedentary lifestyle were assessed through a structured questionnaire and physical examination. By using fully automated open-system analyzer, determinations of total cholesterol, triglycerides, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) three times and glucose twice were performed simultaneously and then their averages were calculated. At least one abnormal lipid level was considered as “dyslipidemia”. The atherogenic index of plasma (AIP) was calculated as the logarithmically transformed ratio of molar concentrations of TG to HDL-C. Statistical analysis was performed using SPSS 22. RESULTS: Of total 117 participants ranging 40-72 years old, 45.3% were male and 54.7% were female with mean age 53.6±0.79. Regarding cardiovascular risk factors, 63.8% were physically inactive, 32.48% were smokers, 47% were alcohol user, 48% were hypertensive, and 18.26% were diabetic. The mean values plus standard error of lipid components were 195.5±6.09 mg/dL in cholesterol, 181.25±27.36 mg/dL in triglycerides, 60.6±1.39 mg/dL in HDL-C, 138.5±3.74 mg/dL in LDL-C, 6.27±0.26 mmol/L in fasting glucose. The dyslipidemia was detected in 54.7% of total participants and mean level of AIP was 0.33±0.03 (min=-0.52; max=1.51). The mean levels of 10 year and lifetime risk were 6.25±0.63% (min=0.2; max=33.5) and 43±1.53% (min=7.5; max=69), respectively. AIP had weak correlations with gender, smoking, anti-hypertensive drug usage, aspirin usage, 10 year and lifetime risks of CVD, hypertension, fasting glucose, body mass index, and dyslipidemia (0.2

Background: Organ transplantation has been rapidly advancing in Mongolia in recent years. The number of successful kidney, liver, and bone marrow transplants performed in national central hospitals has been increasing annually. While the number of successful kidney transplants is increasing, post-transplant immune monitoring remains insufficiently studied. Aim: To assess post-transplant immune status by analyzing inflammatory cytokine levels in kidney transplant recipients Materials and Methods: A prospective cohort study was conducted at the First Central Hospital of Mongolia. Serum samples from kidney transplant recipients were analyzed using flow cytometry to measure the levels of 13 inflammatory cytokines, including TGF-β1, PAI-1, sTREM-1, PTX3, sCD40L, sCD25 (IL-2Ra), CXCL12 (SDF-1), sST2, sTNF-RI, sTNF-RII, sRAGE, CX3CL1 (Fractalkine), and sCD130 (gp130). Statistical analysis was performed to assess the results. Results: The mean creatinine level significantly decreased on post-transplant days 7 and 30 compared to pre-transplant levels (p<0.001, ANOVA). No statistically significant difference was found in the 13 cytokine levels between the high risk and low-risk groups based on creatinine levels on post-transplant day 30 (p>0.05). However, the levels of TGF-β1, CX3CL1, sTREM-1, and sTNF-RI showed statistically significant differences between post-transplant days 7 and 30 (p<0.05). No significant correlation was found between the measured cytokine levels and CRP (p > 0.05). On post-transplant day 7, sTREM-1 had a weak correlation with TGF-β1 (r=0.40, p=0.02) and sTNF-RI (r=0.36, p=0.05) but showed a strong correlation with CX3CL1 (r=0.65, p=0.0001). On post-transplant day 30, sTREM-1 remained strongly correlated with CX3CL1 (r=0.73, p=0.0001) and moderately correlated with sTNF-RI and TGF-β1 (r=0.45, p=0.01). Conclusions 1. The levels of TGF-β1, CX3CL1, sTREM-1, and sTNF-RI significantly varied between post-transplant days 7 and 30 (p< 0.05, T-test). 2. On post-transplant day 30, these cytokines were not correlated with CRP but were interrelated among themselves.

Abstract The aim of this study is to compare the effects of traditional and conventional treatment of chronic pyelonephritis. Total of 100 patients diagnosed with chronic pyelonephritis were enrolled in the study. Traditional medicines included following: Sugmel-10, Sarichun, Yuna-4, Sema-3, and Sojid-11. Conventional medicines included following: ciprofloxacin, cefasolin, and negram. After 10-14 days of treatment questionnaire, physical examinations, and laboratory tests were performed. In 90% of patient treated with traditional medicines, changes of smell and color of urine was disappeared. Back pain and dysuria was reduced in 89.7% and 75% of patients respectively. While in control or conventional treatment group, changes of smell and color of urine was completely disappeared and back pain and dysuria was reduced in 80% and 88% of patients respectively. Pasternatskii’s symptom and arterial hypertension was reduced in about 58% and 77% of patients respectively. Bacterial growth (Escherichia coli and Staphylococcus aureus) was ceased in 39.4% and reduced in 46.4% of patients treated with traditional medicines. It was ceased in 60% and reduced in 30% of control patients.Traditional medicines reduced signs and symptoms of chronic pyelonephritis. Bacterial growth was ceased or reduced by traditional treatment. Traditional medicines are effective as conventional medicines for treatment of chronic pyelonephritis.