1.Do intra-operative fluids influence the need for post-operative cardiotropic support after a PDA ligation?
Brigitte LEMYRE ; Ling LIU ; Gregory Paul MOORE ; Sarah Linda LAWRENCE ; Nicholas J BARROWMAN
Chinese Journal of Contemporary Pediatrics 2011;13(1):1-7
OBJECTIVETo investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic stability.
METHODSWe performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus (PDA) ligation in one NICU between 2001 and 2007. The primary outcome was the need for cardiotropic support within 24 hrs of ligation.
RESULTSTwenty-seven infants (28%) required post-operative cardiotropic support. The amount of intra-operative fluids varied between 0 and 50.4 mL/kg (median: 10.2 mL/kg). No intra-operative fluid was recorded in 26 patients. Fluids were not associated with the need for post-operative cardiotropic support (P=0.10). Using a multivariate logistic regression model, age at ligation, weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic support.
CONCLUSIONSIntra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support. A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.
Cohort Studies ; Ductus Arteriosus, Patent ; physiopathology ; surgery ; Fluid Therapy ; Hemodynamics ; Humans ; Infant, Newborn ; Infant, Premature ; Ligation ; Retrospective Studies
2.Heterogeneous t(4;11) fusion transcripts in two infants with acute lymphoblastic leukemia.
Harvindar Kaur Gill ; Sew Keoh Ten ; Jasbir Singh Dhaliwal ; Sarah Moore ; Roshida Hassan ; Faraiza Abdul Karim ; Zubaidah Zakaria ; Shahnaz Murad ; Mahfuzah Mohamed ; Hishamshah Mohamad Ibrahim ; Eni Juraida Abdul Rahman
The Malaysian journal of pathology 2004;26(2):105-10
An RT-PCR assay detected the t(4;11) translocation in two infants with acute lymphoblastic leukemia (ALL). Case P76 was a 10-month-old, female infant, who presented with a WBC of 137.4 x 10(9)/l and a pre-pre-B ALL immunophenotype. Case P120 was a 6-month-old female infant, with a WBC > 615 x 10(9)/l and a pre-pre-B ALL immunophenotype. RT-PCR of cDNA from both these cases generated a 656 bp and a 542 bp respectively, which sequencing confirmed as t(4;11) fusion transcripts. The primers and conditions selected for this assay are compatible with a one-step multiplex PCR for the main translocations in childhood ALL.
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Leukemia, Lymphocytic, Acute
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Reverse Transcriptase Polymerase Chain Reaction
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