1.Regular monitoring plasma CMV-DNA level and risk factors analyzing after allogenic hematopoietic stem cell transplantation
Huan LI ; Sanling ZHANG ; Jianchuan DENG ; Ying ZHANG ; Shifeng LOU
Chongqing Medicine 2015;(29):4036-4038,4041
Objective To observe the positive rate of plasma cytomegalovirus DNA(CMV‐DNA) level after allogenic hema‐topoietic stem cell transplantation (allo‐HSCT) ,analysis and explore the risk factors related to CMV infection .Methods Choose 30 patients who had performed allo‐HSCT in our department from July 2012 to September 2014 .PCR were used regularly to detect the plasma CMV‐DNA levels in these patients .The regular monitoring times were as follow :the first month(once a week) ,the second to third month(twice a week) ,the fourth to sixth month(once a month) after allo‐HSCT respectively .The positive rates were coun‐ted in every period .Results Thirteen patients had CMV infection ,and the infection rate were 43 .3% .In the first month ,there were 4 cases (13 .3% )whose plasma CMV‐DNA levels were positive ,however ,the positive cases in the second month ,the third month , the fourth month ,the fifth month and the sixth month were 11(36 .7% ) ,2(6 .7% ) ,0 ,2(6 .7% ) and 0 respectively .Statistical data showed that it was in the second month after allo‐HSCT that the CMV‐DNA positive rate was higher than other periods .The anal‐ysis suggested that the positive rate of CMV‐DNA related to the administration of rabbit anti‐human thymocyte globulin(ATG) ,ba‐siliximab ,and the occurrence of acute graft versus host disease(GVHD) ,there were no relationship among gender ,age ,risk stratifi‐cation of primary disease ,HLA condition ,preparative project ,recovery time of neutrophile granulocyte .Conclusion It is necessary and beneficial to monitor blood CMV‐DNA level regularly and take treatment early to avoid CMV related comobidity after allo‐HSCT .
2.Research on a special model of nerve impulse propagation.
Xiangzheng LI ; Weiguo ZHANG ; Sanling YUAN
Journal of Biomedical Engineering 2010;27(5):1142-1145
Hodgkin-Huxley (HH) nerve model is a famous model which is used to describe nerve impulse propagation in nerve fibre. FitzHugh-Nagumo (FHN) model is a simplification of HH model, and Huxley equation is a special case of FHN equation. It has been shown that Huxley equation possesses the basic characteristics of nerve model. Researching on these models was often carried out in virtue of numerical techniques in the past. And, in so for as is known, an efficient and simple method which can be used to obtain analytic solutions is lacking. Yet, a qualitative analysis on Huxley equation's traveling system has been carried through in this paper. There is a bounded heteroclinic orbit having its one end in connection with a saddle point for the traveling wave system. Then a linear plane autonomous system whose singular point is a saddle point is chosen. By means of the system orbit vector's slope, and according to homogeneous balance principle, the traveling wave solutions of Huxley equation's traveling system are constructed. The method used here is called LS method.
Action Potentials
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physiology
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Brain
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physiology
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Computer Simulation
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Humans
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Models, Neurological
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Neural Conduction
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physiology
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Neurons
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physiology