Objective: To enable an artificial mandible substitute to be with individualized shape in the individual patient. Methods: Rapid prototyping and surface imitating were used as the primary technology in the individualized design and manufacturing of the artificial mandible substitute. Results: The shape and size of the manufactured artificial mandibe were almost the same to those of the original natural one. Conclusion: Rapid prototyping may be used in individualized bone substitute preparation.

Objective: To analyse the effects of CVP chemotherapy through arterial injection (CVPC) in the treatment of squamous cell carcinoma (SCC) of maxillary sinus.Methods:39 cases of primary squamous cell carcinoma of maxillary sinus at stage Ⅳ (M0) were treated with following regimen : carboplatin 300～350 mg/m 2 ia gtt on d1, etopside 100 mg ia gtt on d1～5, pingyangmycine 8 mg ia gtt on d1～5. The drugs were given through superficial temporal artery at the level of internal maxillary artery. Gave one cycle treatment before operation which was practised 4 weeks later.Results:Partly remission was found in all patients after chemotherapy. Pathological margin of original focus was negative after operation. 5 cases lost follow up. 4 cases were dead of distant metastasis (after 5,7,8 and 12 months respectively). 30 cases were alive without tumour. 17 cases were over 5 years, 6 over 3 , 4 over 1 and 3 less than one year.Conclusion: CVP arterial injection chemotherapy is effective in the treatment of SCC of maxillary sinus at late stage.

Objective:To explore the efficacy of total sternotomy or partial sternotomy for the treatment of isolated plasmacytoma of the sternum, and the feasibility of the chest wall reconstruction using 3D printed polyether ether ketone(PEEK) implants.Methods:In this study, a total of 6 patients with isolated plasmacytoma of sternum was enrolled, including 5 males and 1 female, aged (57.7±9.4) years old (42-71 years old). All patients received total sternotomy or partial sternotomy, and the chest wall was reconstructed using 3D-printed PEEK implant. The perioperative data and demographic characteristics of the patients were collected for statistical analysis.Results:All patients in this study had isolated plasmacytoma of sternum. Chest wall defects with mean area of (102.7±18.8)cm 2 were anatomically repaired using 3D-printed PEEK implants. No postoperative complications such as abnormal respiration was found. All 6 patients were discharged from hospital successfully, and no complications during the perioperative period were found. During the average follow-up period of(31.2±15.4)months, no implant fracture, displacement, rejection and other phenomena occurred, and no recurrence, metastasis or death occurred in postoperative patients. Conclusion:Total or partial sternotomy was an effective treatment for isolated sternum plasmocytoma . The chest wall reconstruction using 3D-printed PEEK implant was a reliable clinical treatment method.

Objective:To investigate the safety and feasibility of Ivor-Lewis procedure under uniportal video-assisted thoracoscopy(VATS) for esophageal cancer and Siewert type I esophago-gastric junction carcinoma.Methods:The patients with middle-lower segment esophageal cancer or Siewert type I esophago-gastric junction carcinoma received minimally invasive esophagectomy between October 2020 and June 2021, and the clinical data was collected and analyzed.Results:26 patients received Ivor-Lewis procedure underwent uniportal VATS, while 45 patients underwent McKeown surgery under multiport VATS. The average operation time of patients in the two groups were(265±110)min and (235±94)min, and the average intraoperative blood loss were(80±57)ml and(105±60)ml. The mean number of lymph nodes removed in the surgery were (19.3±2.9) and 18.6±2.7 respectively in two groups, and the mean length of hospital stay was(7.5±3.5)days and(8.3±2.7)days. The incidence of perioperative complications were not significantly different in two groups. The VAS score of patients received Ivor-Lewis procedure underwent uniportal VATS was lower than that of patients received McKeown surgery in ostoperative day 1, day 3, day 7 and 1 month. The difference was statistically significant in two groups( P<0.05). Conclusion:The Ivor-Lewis procedure under uniportal VATS for esophageal cancer and Siewert type I esophago-gastric junction carcinoma has the advantage of less postoperative pain, and the procedure is feasible in clinical practice.