In recent years, increasing cases of Plasmodium vivax complications had been reported all
over the world. This former benign Plasmodium species is now recognized to be one of the
human malaria parasites that can produce severe disease. In this article, we report two
cases of sub-microscopic P. vivax malaria confirmed by PCR. Both patients were asymptomatic
before treatment. They showed unusual presentations few days after initiation of
antimalarial treatment. Both patients had subsequently completed antimalarial treatment
and recovered completely.