An HPLC method was proposed to determine rapidly and simultaneously benzoic acid and salicylic acid in the benzosali ointment. The chromatographic conditions were: column lichrosorb RP 18 (25x4x10), mobile phase: methanol - 0.017 M, postassiumdihydrophosphat solution - 12.5%, tetrabutylamonium hydroxide solution (400: 800: 1.5 V/V/V) at flow rate 1-1.5ml min-1 and the detection at 230nm. Experimental results proved that the proposed HPLC method was simple, stable, accurate and precise.
Ointments ; benzoic acid ; salicylic acid

Background: Verruca vulgaris are scaly, rough papules or nodules caused by the human papilloma virus. Objective: To determine the efficacy and safety of topical zinc oxide ointment versus topical salicylic acid + lactic acid ointment as treatment among patients with verruca vulgaris. Methods: This randomized, double-blind, 6-week study involved 29 patients with verruca vulgaris in a tertiary center who received zinc oxide 20% ointment or salicylic acid 15% + lactic acid 15% ointment applied daily and occluded with LeukoplastTM tape. Evaluation was done every two weeks. Results: There was significant decrease in number of warts in the zinc oxide group (p=0.004), while it was not significant in the salicylic acid+lactic acid group (p=0.392). Comparison between the two groups was not significant (p>0.05). Both zinc oxide (P=0.000) and salicylic acid+lactic acid groups (P=0.025) had significant decrease in size of warts from baseline to 6th week of observation. No significant differences were observed between the two groups in terms of adverse events such as erythema (P>0.05), edema (P>0.05), tenderness (P>0.05), and scaling (P>0.05); however, itching was significantly higher at 4th week in the salicylic acid+lactic acid group B (16.7%). Among the zinc oxide group, 100% would recommend the treatment, while only 71.4% would recommend salicylic acid+lactic acid. The satisfaction levels of zinc oxide group were also statistically higher than salicylic acid+lactic acid group (p=0.000). Conclusion Zinc oxide 20% ointment is a safe and effective option for the treatment of verruca vulgaris especially among patients that would prefer non-traumatic measures in the removal of their warts.
Zinc Oxide ; Salicylic Acid ; Lactic Acid

Background: Common warts are a common malady among patients. Not only does it affect the person physically but also mentally and socially. Several treatment modalities are available; however, the major concerns are the treatment cost and adverse effect profile. Salicylic + lactic acid (SLA) solution is one of the standard treatment modalities owing to its strong keratolytic properties; however, its cost and adverse effects limit its use among patients. A cost-effective and safe alternative treatment is ideal to bring about a more favorable clinical outcome and better patient satisfaction. 100% tea tree oil (TTO) solution was used in this study due to its natural antiviral and anti-inflammatory properties. Objective: The study aimed to compare the safety and effectiveness of 100% TTO versus SLA solution in the treatment of common warts. Methods: A total of 17 patients with a total of 74 warts were included in the study. Each wart was assigned to either of the two treatment groups. the SLA group and the 100% TTO group. A treatment period of 6 weeks was used to assess the effectiveness of both treatment groups. Results: The study showed no significant difference between the SLA solution and 100% TTO in the treatment of common warts. The 100% tea tree group reported lesser adverse effects. Both treatment groups reported favorable treatment satisfaction. Conclusion 100% TTO is a potentially safe and cost-effective alternative in the treatment of common warts.
Lactic Acid ; Salicylic Acid ; Tea Tree Oil

Four heterocyclic salicylamine derivatives were prepared by condensing of aminoheterocyclic compounds with salicylic acid or its derivatives. The structure of the obtained products were determined by elemental analysis and IR spectroscopy. The sudy indicated that most of them had grater antibacterial and antifungal activities than salicylamide, but all of them did not have effect on Candida albicans.
Chemical synthesis ; Analogs & derivatives ; Salicylic Acid

1. Napotol solution was topically applied on a trial basis for the treatment of superficial fungal infections and 56% of patients had an excellent benefit and 14% of patients had an irritant dermatitis during the treatment. 2. The main compoeition of Napotol solution is drived from ethsnolie extraction of a natural plant and it's pharmacological action to fungal infection is not known,, yet it's antifungal action is potent as compared to other antifungal topical medicines, Napotol solution also including salicylic acid and benzoic acid, which are well known as possessing a potent antifungal property, may be accelerating it's function for the treatment of superficial fungal infection.
Arthrodermataceae* ; Benzoic Acid ; Dermatitis, Irritant ; Humans ; Plants ; Salicylic Acid

Salicylate 2-O-β-d-glucoside (SAG) is a derivative of salicylate in plants. Recent reports showed that SAG could be considered as a potential anti-inflammatory substance due to its anti-inflammatory and analgesic effects, and less irritation compared with salicylic acid and aspirin. The biological method uses renewable resources to produce salicylic acid compounds, which is more environmentally friendly than traditional industry methods. In this study, Escherichia coli Tyr002 was used as the starting strain, and a salicylic acid producing strain of E. coli was constructed by introducing the isochorismate pyruvate lyase gene pchB from Pseudomonas aeruginosa. By regulating the expression of the key genes in the downstream aromatic amino acid metabolic pathways, the titer of salicylic acid reached 1.05 g/L in shake flask fermentation. Subsequently, an exogenous salicylic acid glycosyltransferase was introduced into the salicylic acid producing strain to glycosylate the salicylic acid. The newly engineered strain produced 5.7 g/L SAG in shake flask fermentation. In the subsequent batch fed fermentation in a 5 L fermentation tank, the titer of SAG reached 36.5 g/L, which is the highest titer reported to date. This work provides a new route for biosynthesis of salicylate and its derivatives.
Escherichia coli/genetics* ; Glucosides ; Metabolic Engineering ; Salicylic Acid ; Pyruvic Acid

A case of 39-year-old male with keratosis palmoplantaria nummularis was reported. The skin lesions were characterized by the presence of painful focal keratoses on the plantar pressure points. Biopsy of a keratotic plantar lesion revealed excessive hyperkerstosis, hypergranulosis, focal hypogranulosis, and acanthosis in the epidermis. We could observe aymptomatic relief of this patient who was treated with mixture of corticosteroid, 25% urea and 2.5% salicylic acid.
Adult ; Biopsy ; Epidermis ; Humans ; Keratosis* ; Male ; Salicylic Acid ; Skin ; Urea

The depigmenting activity of 4-isopropylcatechol and hydroquinone, and the behaviour of salicylic acid affecting to the activity were studied. To the hydrophilic ointment base, 4-isopropylcatechol and hydroquinone were incorperated respectively in concentrations of l% and 3%, and to these creams, salicylic acid was also added in concentration of 3% and 5% respectively. These creams were applied topically to the epilated skins of the back of black guinea pigs once a day for 3 weeks. Followings were the results: 1) The depigmenting activity was found to be more potent in 4-isopropylcatechol than in hydroquinone. 2) The depigmenting activity of hydroquinone was found to be remarkably accelerated by the addition of salicylic acid. 3) The skins of guinea pigs were found to be mildly irritated by the application of both 4-isopropylcatechol and hydroquinone.
Animal Experimentation* ; Animals* ; Guinea Pigs ; Salicylic Acid ; Skin

Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by the deposition of amyloid in the papillary dermis. A variety of therapeutic regimens for LA have been described. However, many of these have been shown to have limited effect. We report the successful, long-lasting resolution of LA and marked improvement of pruritus in one patient who was treated with the combination of topical corticosteroid and salicylic acid 25% ointment. We suggest this combination therapy as an efficacious treatment for LA.
Amyloid ; Amyloidosis ; Dermis ; Humans ; Lichens ; Pruritus ; Salicylic Acid ; Skin

Although there are many methods for the treatment of actinic cheilitis including cryotherapy, vermilionectomy, and topical fluorouracil, the choice of treatment should be determined after assessment of the lesion and its location. A 67-year old woman developed actinic chelitis, where a thick keratotic plaque occupied a half of her lower lip. Surgical removal of the lesion was difficult because of its size, and repeated cryotherapy treatment also failed. The lesion was then successfully treated by a the topical application of combined fluorouracil and salicylic acid solution.
Actins* ; Aged ; Cheilitis* ; Cryotherapy ; Female ; Fluorouracil ; Humans ; Lip ; Salicylic Acid