Objective To explore the application effect of quality control for medical records of clinical pathway .Methods The 127 clinical pathway patients with acute ST segment elevation myocardial infarction were randomly divided into two groups .69 patients with clinical pathway quality control were taken as test group , while 58 patients without clinical pathway quality control were taken as control group.The hospitalization duration, total hospitalization expenses and various events expenses were compared between these two groups.Results The average hospitalization duration in test group was (10.32 ±2.03) days, while that in control group was (12.10 ±2.96) days, with statistically significant differences between the groups (p<0.05).The average hospitalization ex-pense in the test group was (52,349.94 ±16,944.22) yuan, while that in control group was (59,522.81 ±22,783.01) yuan, with statistically significant differences between the groups (p<0.05).Among various events of hospitalization expense, the medicine cost and nursing fee in the test group were lower than those in control group, with statistically significant differences (p<0.05), and no statistically significant differences were found in the other items (p>0.05).Conclusion The quality control for medical records of clinical pathway can effectively control the hospitalization duration and hospitalization expense , standardizing the implementation of clinical pathway.