Objective] Make a research on curative properties from the aspect of zang-fu differentiation in dysuria of Zhang Zhong-Jing. [Methods] Detailly discussed about the properties of dysuria from five aspects: lung, spleen, kidney, triple energizer and bladder. Combine these factors with articles in Treatise on Exogenous Febrile Disease to estimate the condition of body fluid and prognosis of the disease. [Results]The several methods to diagnose and treat dysuria from the idea of Zang-fu Theory, such as ventilating lung and relieving the exterior, invigorating spleen and dissipating excessive fluid, purging and benefiting triple energizer, warming kidney and transforming qi, promoting urination and activating yang. Smooth or not of urine could help to locate the lesion viscera, determine the attribute of deficiency and excess of etiology and judge the prognosis of diseases. [Conclusion]Zhang Zhong-Jing ’s Zang-fu syndrome differentiation theory is an effective way to diagnose and cure dysuria in clinical practices, it is worthy of further research.

This article introduced three proved cases of gynecological disease: amenorrhea, climacteric syndrome and breast nodules, which were treated by HE Sai-ping doctor. He insisted that the gynecological diseases could be treated based on spleen and liver, of which regulating qi-blood was the therapeutic core.

Objective:To investigate the incidence and influencing factors of allergic reactions to cephalosporins.Methods:A cross-sectional study of 29 medical institutions in Zhejiang Province was conducted from April 2021 to June 2021.The incidence of allergic reactions to cephalosporins was investigated,and the influencing factors of cephalosporin-induced allergic reactions were analyzed by Poisson regression.Results:A total of 56 155 patients were included in this study.The total incidence of allergic reactions to cephalosporin was 1.67‰,the highest incidence of anaphylaxis occurred for ceftizoxime(4.27‰),followed by ceftriaxone(3.49‰)and cefotaxime(2.40‰).There was no significant difference in the incidence of allergic reactions between patients with negative skin tests and those without skin tests(1.75％o vs.1.63‰,RR=1.07,95％CI:0.70-1.63,P＞0.05).Poisson regression showed that body mass index(BMI)＜18.5 kg/m2(RR=2.43,95％CI:1.23-4.82,P＜0.05)and history of β-lactam antibiotics allergy(RR=33.88,95％CI:1.47-781.12,P＜0.05)increased cephalosporin-induced anaphylaxis.Compared with cefuroxime,the risk of allergic reactions was increased for ceftriaxone(RR=3.08,95％CI:1.70-5.59,P＜0.01),ceftazidime(RR=1.89,95％CI:1.03-3.47,P＜0.05),and ceftizoxime(RR=3.74,95％CI:1.64-8.50,P＜0.01).Conclusions:Lower BMI and history of β-lactam antibiotics allergy increase the risk of cephalosporin allergic reactions.The routine skin test may not reduce the occurrence of allergic reactions to cephalosporins. This study has been registered at Chinese Clinical Trial Registry(ChiCTR2200064314).

OBJECTIVE To review the application and development of automatic intelligent drug cabinet in hospitals at home and abroad. METHODS The relevant research articles published from 2010 to 2022 were retrieved from CNKI, Wanfang, VIP, PubMed and other databases. RESULTS The application of automatic intelligent drug cabinet could shorten the execution time of inpatient medical orders, improve the work efficiency of pharmacists and doctors and nurses, improve the quality of drug management in wards and promote the transformation of hospital pharmaceutical care. CONCLUSION The construction of decentralized dispensing mode with automated intelligent drug cabinets as the core has important theoretical guiding significance and broad application prospects for the automation, informatization, intelligence and whole process management of drugs in medical institutions, and also helps to improve the level of medical pharmacy service management.