Objective To investigate the the effect of motherwort on metalloproteinases in decidual tissue in the treatment of abnormal uterine bleeding induced by drug abortion in patients.Methods 76 patients with abnormal uterine bleeding by drug abortion in this study form Cangnan County Maternity & Child Healthcare Hospital were selected and divided into 2 group, 38 cases of each group.The control group received mifepristone, misoprostol and progynova treatment,the experimental group received more with motherwort.The serum hormones change and matrix metalloproteinases in decidual tissue by S-P method were determine,while adverse reaction were compared after the treatment.Results Compared with before treatment,levels of serum estradiol increased,progesterone decreased,content of the matrix metalloproteinase(MMP-3)and MMP-9 in decidual tissue increased,tissue inhibitor of metalloproteinase(TIMP-1)in decidual tissue decreased,the differences were statistically significant(P<0.05),compared with the control group,levels of serum estradiol in the experimental group were higher,progesterone were lower,contents of MMP-9 and MMP-3 in the tissues were higher, levels of TMP-1 were lower, and bleeding duration was shorter, vaginal bleeding was less ( P <0.05 ) .Conclusion Motherwort in the treatment of abnormal uterine bleeding by drug abortion in patients has good curative effect,it could increase the levels of MMP-3 and MMP-9,reduce levels of TIMP-1 in decidual tissue,and reduce the bleeding time and bleeding volume.