1.Paediatric cholesteatoma: Experience of Universiti Kebangsaan Malaysia Medical Centre
Bee See GOH ; Jian Woei TEOH ; Rahim FAIZAH ; Saim LOKMAN ; Abdullah ASMA
Brunei International Medical Journal 2012;8(2):71-77
Introduction: Cholesteatoma is an aggressive disease and its management poses a greater challenge in children than in adults. This study reviews the experience of Universiti Kebangsaan Malaysia Medical Centre in the clinical presentation and management outcome of acquired cholesteatoma in paediatrics that required surgical interventions. Materials and Methods: A retrospective review of case records of patients below 18 years old who underwent surgery from 1999 to 2010. Results: A total of 46 patients presented with 53 cases of cholesteatoma in which seven patients had bilateral disease. The age of presentation ranged from four to 18 years old with a mean age of 12 years. Male and female patients were 65% and 35% respectively. Otorrhoea or previous history of otorrhoea on presentation was found in 94% and 96% of them had hearing impairment. Cerebellopontine angle abscess, sigmoid sinus thrombosis and mastoiditis were among the complications. Tympanic membrane was retracted in 64% while 47% having had attic retraction and 53% had total atelectasis. A majority (85%) underwent canal wall down surgery with or without tympanoplasty. Post-operatively, 71% had improvement or preserved hearing level. The duration of follow up ranged from one month to 13 years and a quarter had recurrent disease and underwent revision surgeries. Conclusion: Majority of the cholesteatoma patients suffered from hearing loss and otorrhoea. Tympanic membrane retraction remained the most common clinical finding. Hence, children with persistent otorrhoea after adequate treatment may represent cholesteatoma. Surgical options of canal wall up and canal wall down procedures have equal risk of recurrence.
Cholesteatoma
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Hearing Loss
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Recurrence
2.Mastoid Abscess in Acute and Chronic Otitis Media
Mazita Ami ; Zahirrudin Zakaria ; Goh Bee See ; Asma Abdullah ; Lokman Saim
Malaysian Journal of Medical Sciences 2010;17(4):44-50
Background: Mastoid abscess remains a recognised complication of otitis media despite
the advent of antibiotics. The objectives of this study were to describe the risk factors in patients
with mastoid abscess following acute and chronic otitis media and discuss the management of this
infection.
Method: A retrospective analysis was done on all patients who underwent mastoidectomy
for mastoid abscess from January 2002 to December 2007. Data on the patients’ presentation,
associated complications, management, and follow-up were analysed.
Results: A total of 12 patients were enrolled in this study population. Group A consisted of
patients with mastoid abscess preceded by acute otitis media, while Group B consisted of patients
with mastoid abscess and chronic otitis media. In Group A (n = 7), 4 patients had a pre-morbid
immunocompromised condition, but they did not have cholesteatoma. None of the patients in Group
B (n = 5) had any pre-morbid illnesses. Out of 12 patients, 7 patients had associated extracranial
complications, and 1 patient had intracranial complications. Most patients recovered well after
mastoidectomy. Recurrence was noted in 1 patient who had acute lymphoblastic leukaemia.
Conclusion: Mastoid abscess is still a recognised complication of acute otitis media, especially
in patients who are immunocompromised. Immunocompetent patients may also develop mastoid
abscess following chronic otitis media associated with cholesteatoma. Thus, early treatment of otitis
media and close vigilant follow-up are advocated to ensure prompt detection of mastoid abscess
complications.
3.Metastasis to the sinonasal tract from sigmoid colon adenocarcinoma.
; Lokman bin SAIM ; Roszalina bte RAMLI
Annals of the Academy of Medicine, Singapore 2008;37(9):788-783
INTRODUCTIONMetastatic adenocarcinoma from the gastrointestinal tract to the sinonasal tract is rare. The histological morphology of this lesion is indistinguishable from the colonic variant of primary sinus adenocarcinoma or intestinal-type adenocarcinoma (ITAC).
CLINICAL PICTUREThis is a report of a case of metastatic adenocarcinoma of colorectal origin to the paranasal sinuses in a 52-year-old female who was previously treated for adenocarcinoma of the sigmoid colon. A histologic study of the surgical specimen from the sinonasal cavity demonstrated a tumour identical to the patient's prior primary tumour of the colon. The sinonasal neoplastic tissue showed marked positivity for carcinoembryonic antigen and expressed cytokeratin 20, which differentiates metastatic colonic adenocarcinoma from ITAC.
TREATMENT/OUTCOMEThe patient received palliative radiation but died 3 months after the diagnosis.
CONCLUSIONDistinguishing metastatic adenocarcinoma from gastrointestinal tract from ITAC can be difficult. In view of the resemblance, immunohistochemical staining can help in differentiating them. It is important to recognise these as metastatic lesions as the treatment is mainly palliative.
Adenocarcinoma ; metabolism ; radiotherapy ; secondary ; Carcinoembryonic Antigen ; metabolism ; Colorectal Neoplasms ; pathology ; Fatal Outcome ; Female ; Humans ; Keratin-20 ; metabolism ; Middle Aged ; Palliative Care ; Paranasal Sinus Neoplasms ; metabolism ; radiotherapy ; secondary