Burnout, Professional ; Humans

Humans ; Occupational Health ; Stress, Psychological

Humans ; Occupational Exposure ; prevention & control ; Occupational Health Services ; standards

Ergonomics ; Humans ; Musculoskeletal Diseases ; Occupational Diseases

The process of unfolded or misfolded proteins accumulated in the endoplasmic reticulum lumen termed endoplasmic reticulum stress (ERS), which can result in a variety of prevalent disease, such as autoimmune diseases, neurodegenerative diseases, metabolic disorders and cancer.In order to alleviate the pressure of ERS, eukaryotic cells produce a kind of adaptive intracellular signaling pathway which we called unfolded protein response (UPR, which main role is to remove misfolded proteins and restore endoplasmic reticulum homeostasis.However, apoptosis will be trigger if ERS increases continuously.There are many endoplasmic reticulum in Liver cells, the development of liver cancer is closely related to ERS and apoptosis.Therefore, finding a new method for the treatment of liver cancer in theory from the ERS induced apoptosis pathway seems so meaningful.

Twenty-four rabbits' patellar ligaments were elongated 3 mm surgically, which decreased the pressure of the patellar articular cartilage. The pathological changes of cartilage and subchondral bone of the patellar were examined by light microscope and scanning electron microscope sequentially. 4 weeks after the surgery, proliferation of blood vessels in the subchondral bone and their invasion into the calcafied cartilage were seen, without abnormality in the patellar articular cartilage. After 8 weeks, irregularity of the tide mark and cartilage cells column, and peripheral part of the cartilage showed cluster formation. After 12 weeks, degeneration extended to the superficial layer of the cartilage, producing blister formation, fibrillation and a decrease in the thickness of the cartilage. These findings were similar to the histological changes of chondromalacia patellae. It was further suggested that decrease of pressure on the cartilage could be considered to be one of the causes for articular cartilage injury, and patella alta be correlated with chondromalacia of the patella.

Radiation pneumonitis (RP) is the most common adverse event of thoracic radiotherapy, which primarily occurs within the 3 months after the beginning of radiotherapy. RP can not only negatively affect the pulmonary function and quality of life of patients, but also limit the prescribed dose and the implementation of radiotherapy plan, lower the radiotherapy efficacy and even lead to death. Currently, multiple studies have been conducted to explore the predictive factors of RP. In this article, clinical predictive factors including dosimetric parameters, peripheral blood cells along with cytokines and pulmonary function parameters were classified and illustrated, aiming to provide valuable predictive indicators for clinical use and reduce the incidence of RP.

Objective To explore the efficacy of Tai Ji Quan on the elders with mild cognitive impairment (MCI). Methods From June to October, 2015, 108 old people with MCI were divided into control group (n=54) and intervention group (n=54). Both groups studied rele-vant knowledge about MCI and received handbooks. The excise of Tai Ji Quan was regularly conducted in the intervention group at least for-ty minutes a time and four times per week for three months. They were assessed with the Peking Union Medical College Version of Montre-al Cognitive Assessment (MoCA-P) before and after intervention. Results There was no significant difference in the scores of MoCA-P be-tween two groups before intervention (Z<1.425, P>0.05). After intervention, the total scores of MoCA-P, and the scores of visual space func-tion and long delayed recall were higher in the intervention group than in the control group (Z>3.425, P<0.01). Conclusion Tai Ji Quan can effectively improve the cognitive function, especially memory and executive function, in the elderly with MCI.

Manual Muscle Testing is a widely used muscle power testing method in rehabilitation practice. Although it's a key content in rehabilitation medicine and rehabilitation therapy, there are some disagreements in lots of books introducing the development and rating system of it. This article reviewed the development of Manual Muscle Testing and different rating systems.