1.Diabetic hypertensive control and treatment: a descriptive from the Audit Diabetis Control and Management (ADCM) registry
BH Chew ; I Mastura ; AT Cheong ; SAR Syed Alwi
Malaysian Family Physician 2010;5(3):134-139
Introduction: Hypertension is a common co-morbidity in diabetes mellitus (DM) that may lead to serious complications if not adequately controlled.
Method: This is a descriptive study based on data from the Audit of Diabetes Control and Management (ADCM) registry.
This audit assessed the treatment and standard of control of hypertension in diabetic patients aged 18 years and above. Data were analysed using STATA version 9.
Results: From a total of 20 646 cases, about two third of them, 13 417 (65%) were reported to have hypertension. 19 484 (94.4%) had their blood pressure (BP) recorded and out of these, 11 414 (58.5%) were found to have BP >130/80 mmHg. 13 601 cases (65.9%) of the total sample were on antihypertensive drugs. 64.1% of those on antihypertensive drugs were prescribed angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers. 14.2% were on more than two types of antihypertensive drugs. Older patients and those with longer duration of DM were less likely to achieve the target BP of ≤130/80. In general, about 40% of diabetic cases registered in the ADCM project had their hypertension well controlled.
2.RISK FACTORS FOR DIABETIC RETINOPATHY IN DIABETICS SCREENED USING FUNDUS PHOTOGRAPHY AT A PRIMARY HEALTH CARE SETTING IN EAST MALAYSIA
PS Mallika ; PY Lee ; WL Cheahm ; JS Wong ; SAR Syed Alwi ; H Nor Hayati ; AK Tan
Malaysian Family Physician 2011;6(2&3):60-65
Introduction: This study reports on the prevalence of diabetic retinopathy (DR) and risk factors among diabetic patients, who
underwent fundus photography screening in a primary care setting of Borneo Islands, East Malaysia. We aimed to explore the
preliminary data to help in the planning of more effective preventive strategies of DR at the primary health care setting.
Materials and Methods: A cross-sectional study on 738 known diabetic patients aged 19-82 years was conducted in 2004.
Eye examination consists of visual acuity testing followed by fundus photography for DR assessment. The fundus pictures were
reviewed by a family physician and an ophthalmologist. Fundus photographs were graded as having no DR, NPDR, PDR and
maculopathy. The data of other parameters was retrieved from patient’s record. Bi-variate and multivariate analysis was used to
elucidate the factors associated with DR.
Results: Any DR was detected in 23.7% (95% CI=21 to 27%) of the patients and 3.2% had proliferative DR. The risk factors
associated with any DR was duration of DM (OR =2.5, CI=1.6 to 3.9 for duration of five to 10 years when compared to <5 years)
and lower BMI (OR=1.8, CI=1.1 to 3.0). Moderate visual loss was associated with DR (OR=2.1, CI=1.2 to 3.7).
Conclusions: This study confirms associations of DR with diabetic duration, body mass index and visual loss. Our data provide
preliminary findings to help to improve the screening and preventive strategies of DR at the primary health care setting
3.Diabetic Retinopathy and the effect of pregnancy
PS Mallika ; AK Tan ; S Aziz ; T Asok ; SAR Syed Alwi ; G Intan
Malaysian Family Physician 2010;5(1):2-5
Pregnancy is associated with increased risk of development and progression of diabetic retinopathy (DR). Although pregnancy does not have any long term effect on DR, progression of retinopathy changes occur in 50%-70% of cases. The greatest risk of worsening occurs during the second trimester and persists as long as 12 months postpartum. The other factors found to
be associated with its progression include duration of the diabetes, severity of retinopathy at conception, hyperglycaemic control, anaemia and progression of coexisting hypertension. Because of the increased risk of progression of the disease in pregnancy, conception should be delayed till the ocular disease is treated and stabilized and laser photocoagulation should
be promptly instituted in all cases of severe non-proliferative retinopathy and should not be delayed till the patient develops early proliferative changes. Good diabetic control before and during pregnancy can help prevent this increase in the progression
and serious vision loss.
4.Do university students have high cardiovascular risk? A pilot study from Universiti Malaysia Sarawak (UNIMAS)
PY Lee ; TA Ong ; S Muna ; SAR Syed Alwi ; K Kamarudin
Malaysian Family Physician 2010;5(1):41-43
A health screening was done in UNIMAS in August 2008 for 237 undergraduate students. Body mass index (BMI), waist
circumference (WC) and blood pressure (BP) were measured for all subjects. Total cholesterol and glucose levels were
checked for those who fulfilled the screening criteria. The proportion of participants with cardiovascular (CVD) risk factors was high. The strategies for health promotion should not only be targeted to the older community but also to the younger community.
5.Thyroid associated ophthalmopathy- a review
PS Mallika ; AK Tan ; S Aziz ; SAR Syed Alwi ; MS Chong ; R Vanitha ; G Intan
Malaysian Family Physician 2009;4(1):8-14
Thyroid associated ophthalmopathy is an autoimmune disorder affecting the orbital and periorbital tissues. Hyperthyroidism is commonly associated with thyroid associated ophthalmopathy, however in 5% to 10% of cases it is euthyroid. Genetic, environmental and endogenous factors play a role in the initiation of the thyroid ophthalmopathy. Smoking has been identified
as the strongest risk factor for the development of the disorder. The pathogenesis involves activation of both humoral and cell mediated immunity with subsequent production of gycoaminoglycans, hyaluronic acid resulting in oedema formation, increase
extraocular mass and adipogenesis in the orbit. The natural history of the disease progresses from active to inactive fibrotic stage over a period of years. Diagnosis is mainly clinical and almost all patients with ophthalmopathy exhibit some form of
thyroid abnormality on further testing. Treatment is based on the clinical severity of the disease. Non-severe cases are managed by supportive measures to reduce the symptomatology and severe cases are treated by either medical or surgical decompression. Rehabilitative surgery is done for quiescent disease to reduce diplopia and improve cosmesis.
6.Acute Gastroenteritis Among Indigenous Paediatric Patients – A Descriptive Study in a Rural District Hospital, Sarawak
WL Cheah ; PY Lee ; SAR Syed Alwi ; K Kamarudin ; H Albela ; EH Lau ; O Noraini ; WA Siti Sanaa
Malaysian Journal of Medicine and Health Sciences 2011;7(2):3-7
Introduction: Acute gastroenteritis (AGE) is one of the frequent causes of hospitalization in
children under the age of five, particularly in a rural setting. This study was conducted to determine
the epidemiology of acute gastroenteritis in indigenous children admitted to a rural district hospital
in Sarawak. Methods: A retrospective review of indigenous paediatrics cases of acute gastroenteritis
admitted to the ward of Serian District Hospital, a rural district hospital in Sarawak, between the years
2006-2007. The data was collected from the patients’ case notes, obtained with permission from the
hospital management. Data was entered and analyzed using SPSS version 16. Results: During the study
period, 234 indigenous children with acute gastroenteritis were admitted with the highest prevalence in
2006 (53.4%). The findings showed higher prevalence was found in children aged 3 years and below
(76.5%) and male (56.4%) The minimum duration of hospital stay is 1 day, and the maximum stay is
5 days. The clinical findings showed that the majority of the cases presented with vomiting, diarrhea,
dry mouth and tongue, sunken eye, with the majority (76%) reported having mild dehydration. The
most common treatment used is oral rehydration solutions (85.4%), followed by intravenous bolus or
drip (82.3%), paracetamol (79%) and antibiotic (36.2%). Peak incidence of admissions was between
November to January. About 38.5% of the AGE cases admitted were found to be underweight (weightfor-
age below -2SD). Conclusion: The findings indicated children aged 3 years and below are the most
vulnerable to AGE and malnutrition could be one of the predisposing factors. The peak incidence during
the raining season at the end of the year indicated a possible relationship between AGE and seasonal
type of virus infection. Prevention in the form of proper hygiene at the household level probably will
prove to be useful.