Objective:To observe the relationship between carotid intima-media thickness (CIMT) and hemoglobin A1c (HbA1c) control in type 2 diabetes mellitus (T2DM) patients.Methods:328 cases with T2DM were selected from the endocrinology department of our hospital.All patients underwent assessment,biochemical test and CIMT measurement.According to the value of CIMT,patients were divided into normal CIMT group (＜0.9 mm) and abnormal CIMT group (＞0.9 mm).A multi-factor Logistic regression was performed to analyze the risk factors associated with the abnormal CIMT.Results:(1) Among the 328 T2DM patients,154 cases had normal CIMT and 174 cases had abnormal CIMT.(2) Pearson correlation analysis indicated that the cholesterol and HbA1c levels were positively correlated with CIMT (P＜ 0.05).(3) Univariate analysis showed that the incidence of CIMT was associated with age (t=4.132,P=0.041),systolic blood pressure (t=8.456,P＜0.01),HbA1c≥ 9.0％ (x2=9.912,P＜0.01),cholesterol 0=5.549,P=0.018),triglyceride (t=6.592,P=0.008),UA(t=9.618,P＜0.01),fasting plasma glucose (t=4.592,P=0.037).(4) Multi-factor Logistic regression indicated that age,systolic blood pressure,cholesterol and HbA1c≥ 9.0％ were the independent risk factors for the onset of CIMT (P ＜0.05).Conclusions:The level of HbA1c in T2DM patients was associated with CIMT;And HbA1c≥ 9％ was the independent risk factors for the increase of CIMT.

Aim To study the effects of smoking and glonoine on intracellular free Ca2+ concentration([Ca2+]i) in vascular smooth muscle cell in rabbits with atherosclerosis,and to explore the effects of smoking on atherosclerosis and biologic action of glonoine.Methods An atherosclerosis in rabbits was produced.The vascular smooth muscle cells were isolated.The cells were loaded by Fluo-3/AM.[Ca2+]i in vascular smooth muscle cell was measured by flow cytometer(FCM).The spatial distribution and the dynamic changes of [Ca2+]i in single vascular smooth muscle cells were determined by laser scanning confocal microscopy(LSCM).Results Atherosclerosis plaques in arteriae aorta were observed and the degrees were different in various groups.[Ca2+]i in vascular smooth muscle cells in rabbits with atherosclerosis markedly increased[(48.45?5.31) vs that in saline control(38.09?2.57),P