OBJECTIVE:To improve the safety and effectiveness of total parenteral nutrition(TPN),and to provide reference for clinical rational use. METHODS:1400 TPN prescriptions in PIVAS from Jan. to Jun. 2013 were analyzed statistically in re-spects of rationality and stability. RESULTS:Among 1400 TPN prescriptions,there were 433 prescriptions of unreasonable glu-cose-lipid ratio(30.93%),782 prescriptions of unreasonable hot-nitrogen ratio(55.86%),443 prescriptions of unreasonable liquid amount(31.64%),1 261 prescriptions of unreasonable total calorie(90.07%)and 383 prescriptions of unreasonable treatment du-ration (27.36%). CONCLUSIONS:TPN prescription design is reasonable,but there are still some problems as low calorie,too high or too low hot nitrogen ratio,improper electrolyte dosage,improper duration of nutrition support. Clinicians should accurately assess the nutritional status of patients to design the prescriptions rationally and improve clinical safety and effectiveness of TPN. Pharmacists should further ensure the reasonableness of the prescription by prescription checking.