Objective To evaluate the application of fast-FLAIR T 2WI and enhanced fat-suppressed T 1WI in diagnosis of meningeal disorders.Methods Fast-FLAIR T 2WI and enhanced fat-suppressed T 1WI imaging for 38 patients with meningeal disorders were contrastingly studied.Results Meningeal disorders foci were found in all patients. 55 foci were displayed with fast-FLAIR T 2WI and 59 with enhanced fat-suppressed T 1WI.Conclusions The fast-FLAIR T 2WI and enhanced fat-suppressed T 1WI are all useful to improve the detection of meningeal disorders.

Objective To investigate the correlation between mRNA expression of VEGF,bFGF and dynamic contrast-enhancedT_1-weighted MRI together with conventional MRI features in pituitary adenomas.Methods Conventional MRI and gadolinium-enhanced dynamic Turbo-FLASH imaging was performed preoperatively in 30 patients with histologically verified pituitary adenoms.VEGF and bFGF mRNA expression were determined in pituitary adenomas by using comparative reverse transcription-polymerase chain reaction(RT-PCR) in all patients.The correlation between mRNA expression of VEGF/bFGF and dynamic contrast-enhanced and conventional MRI featureswere studied.Results Significant difference in VEGF and bFGF mRNA expression was found among pituitary adenomas according to different signal intensity-time curve(SI-TC) type(P

OBJECTIVE: To analyze HSP70/HSP27 protein expression in the nasopharyngeal carcinoma (NPC) primary tissues and the residual lesion, and to explore its predictive value. METHODS: Immunohistochemical experiment was performed to detect the expression of HSP70 and HSP27 in 58 NPC primary tissues: 28 were in the experimental group with the local residual lesion and 30 in the control group without recurring and metastasis within 5 years by conventional radiotherapy. RESULTS: The positive expression of HSP70 and HSP27 in the experimental group was 92.9%(26/28) and 53.6%(15/28), while that in the control group was 53.3%(16/30) and 53.3%(16/30),respectively. There was significant difference in the 2 groups. The common positive expression of HSP70 and HSP27 between the 2 groups had significant difference, 50.0% (14/28) in the experimental group and 16.7% (5/30) in the control group, respectively. There was no significant difference in the negative ratio of HSP70 and HSP27 common expression between the 2 groups, 3.6% (1/28) in the experimental group and 10.0% (3/30) in the control group, respectively. CONCLUSION HSP70 may have an important role in the radioresistance of NPC, and may predict the residual lesion after radiotherapy.
Adult ; Aged ; Carcinoma, Squamous Cell ; metabolism ; radiotherapy ; Female ; HSP27 Heat-Shock Proteins ; metabolism ; HSP70 Heat-Shock Proteins ; metabolism ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; metabolism ; radiotherapy ; Young Adult