Objective To eveluate the methods and effects of multiple combined surgery anterior segment reconstruction and secondary posterior chamber intraocular lens implantation. Methods Secondary intraocular lens implantation combined anterior segment was reconstructed in 43 aphakias with different anterior segment disorders. Anterior segment reconstruction included:synechotomy, reposition of iridodialysis, pupil reformation, membranctomy in the pupil erea,anterior vitrectomy. Results The surgery was successful in all patients. The patients were followed up in 6-12 months.The postoperative visual acuities in 36 eyes were ≥0. 3(83. 7% ) and round pupil in 33 eyes (76. 7 % ). No severe complications happened. Conclusion It can have better effect to perform of anterior segment reconstruction and secondary posterior chamber intraocular lens implantation in different conditions with surgeryskill and better equipment.

Wet age-related macular degeneration(wARMD)emerges as a primary contributor to irreversible vision impairment in the aging demographic. In clinical practice, anti-vascular endothelial growth factor(VEGF)therapies exhibit pronounced success in managing wARMD. However, in the actual clinical application, there are significant individual differences in the prognosis of anti-VEGF drug therapy, and some patients show poor response to the treatment, which may be related to the morphological differences of retinal layers in macular area, genetics, systemic conditions and other factors. It will help develop a more rational and individualized treatment plan to judge the prognosis of patients according to their different clinical manifestations in advance, so as to reduce overtreatment and the risk of retinal damage. In recent years, most studies on treatment response mainly focus on fundus morphology, genetics and so on. In this study, the relevant factors affecting adverse response to wARMD were reviewed, aiming to provide with more accurate treatment and prognostic monitoring programs for clinicians.