Objective To study the tactics, methods and relevant factors of interventional treatment for hemorrhage following biliary and pancreatic surgery.Methods Fourteen patients with hemorrhage following biliary and pancreatic surgery were treated by embolization using gelfoam pledgets, PVA granules, metal coils or otherwise by local infusion of vasopressin. Results There were 16 foci in 14 patients with 16 times of interventional treatment, including 3 times using metal coils, 6 times of PVA, 2 gelfoam pledgets, 1 with PVA plus gelfoam pledgets, and 4 of vasopressin. There was 1/16 time failure of using vasopressin due to anastomotic rupture. The successful rate reached 93.8%. Conclusions Interventional treatment is a safe and effective method for hemorrhage following biliary and pancreatic surgery. The key of success is the right selection of embolization or vasopressin infusion for target artery.