1.A SWOT Analysis on the Strategies for Faculty Development
Chinese Journal of Medical Education Research 2003;0(04):-
The paper conducted a descriptive analysis of the current situation of the faculty in the School of the Traditional Chinese Medicine of Capital Medical University.Then,using the framework of SWOT analysis,the paper discussed the external and internal factors related with the faculty development.According to the suggestions collected via expert consultation,strategies for the faculty development were put forward in the last part of the paper.
2.Analysis on application effect of strengthened pulmonary rehabilitation exercise in lung cancer patients with severe pulmonary ventilation dysfunction in perioperative period
Zhili REN ; Ruixin ZHANG ; Mengyao CHEN
Chinese Journal of Practical Nursing 2015;(36):2749-2752
Objective To explore the application effect of strengthened pulmonary rehabilitation exercise in lung cancer patients with severe pulmonary ventilation dysfunction during perioperative period. Methods A total of 96 patients receiving lung cancer radical treatment under thoracoscope in our hospital during March 2013 to April 2015 were collected, and for all these patients, pulmonary function test before treatment showed that there was severe pulmonary ventilation dysfunction. The patients were divided into the routine group and the intervention group by random digital table method, with 48 patients in each group;patients in the routine group received routine perioperative nursing, and those in the intervention group received the strengthened pulmonary rehabilitation intervention plan; change in pulmonary function before treatment, duration of mechanical ventilation, time of oxygen therapy, retaining time of chest tube, length of hospital stay and occurrence of complications after treatment were compared between the two groups. Results After strengthened pulmonary rehabilitation intervention in the intervention group, the FVC was (2.63±0.47) L, the MVV was(53.14±9.40) L, the DLCO was(19.26±2.63) ml·min-1·mmHg-1, the VO2 was (23.15±4.36) ml/kg and the O2Pulse was(10.98±2.52) ml·min-1·times-1, Which were significantly improved compared with those before treatment, (2.41±0.40) L,(46.98±8.91) L,(17.56±2.83) ml·min -1·mmHg -1, (20.17±4.35)ml/kg and(9.82±2.07) ml·min-1·times-1, t=2.521, 3.512, 3.112, 3.421, 2.515, P<0.01 or 0.05. While there was no obvious change in the above- mentioned indexes of those in the routine group. After treatment of patients in the intervention group the duration of mechanical ventilation was (9.42±3.17) hours, time of oxygen therapy was (76.23±21.18) hours, retaining time of chest tube was (3.58±1.44) days and length of hospital stay was (6.62±2.14) days, which were significantly shorter than those in the routine group, (17.29±4.79) hours,(92.14±24.29) hours, (4.73±2.15) days and(8.68±2.96) days. The occurrence rates of complications such as pulmonary infection, pulmonary atelectasis and respiratory failure were 12.50%(6/48),10.42%(5/48) and 4.17%(2/48)in the intervention group, significantly lower than those in the routine group, 41.67%(20/48),29.17%(14/48) and 18.75%(9/48), χ2=10.338, 5.315, 5.031, P <0.01 or 0.05. Conclusions Strengthened pulmonary rehabilitation intervention can improve pulmonary function of lung cancer patients with severe pulmonary ventilation dysfunction before treatment, reduce the occurrence rate of post- operative complications and enhance safety during the perioperative period; it is worth of being further promoted clinically.
3.Application of radiofrequency vaporization in arthroscopic treatment of knee disorders
Ruixin LIN ; Licheng ZHANG ; Guojing YANG
Chinese Journal of Minimally Invasive Surgery 2005;0(10):-
Objective To investigate effects of radiofrequency vaporization in arthroscopic treatment of knee disorders.Methods Arthroscopic surgery was conducted in 126 consecutive cases of various knee disorders by using the Arthrocare 2000 System,includng 72 cases of meniscus injury,20 cases of synovitis,15 cases of osteoarthritis,8 cases of patella subluxation,6 cases of synovial syndrome,and 5 cases of anterior cruciate ligament rupture.Results All the patients were followed postoperatively.Knee function evaluation with the Neer Scores showed excellent outcomes in 82 cases,good in 35 cases,and fair in 9 cases,the rate of excellent-or-good outcomes being 92.9%.Conclusions Application of radiofrequency vaporization under arthroscopy for knee joint disorders has advantages of simple and accurate performance,effective hemostasis,minimal invasion,and quick recovery of joint functions.
4.Small intestinal submucosa:Preparation and application in cardiomyocyte tissue engineering
Yong GUO ; Xizheng ZHANG ; Ruixin LI
Medical Journal of Chinese People's Liberation Army 2001;0(11):-
Objective To prepare the small intestinal submucosa (SIS) to be used as a scaffold in constructing engineered cardiac tissue. Methods Small intestinal submucosa of pig was treated with 0.25% trypsin and then 0.5% SDS for 24 hours each to obtain decellularized SIS. The obtained SIS was tested for its mechanical strength by stretching both horizontally and longitudinally with a material test machine. The cytotoxicity and histocompatibility of the material was also examined. Then the cardiomyocytes harvested from 3-day old neonatal rats were seeded on the SIS to construct engineered cardiac tissue sheets. These acquired engineered cardiac tissue sheets were immunohistochemically stained and observed with inversion microscope and transmission electromicroscope to evaluate their characteristics. Results SIS was decellularized completely. The mechanical capability of the decellularized SIS was satisfactory. Under 15% stretching, its strain and stress was nearly linear. SIS showed no cytotoxicity and inflammatory response. After 12 hours, the cardiomyocytes seeded in the SIS scaffold began to beat spontaneously. Two days later, the cardiomyocytes-SIS scaffold composite (engineered cardiac tissue sheet) began to beat spontaneously, and could beat spontaneously for 14 days. The constructed engineered cardiac tissue sheets consisted of layers of cardiomyocytes and with abundant extracellular collagen in the sheet. Conclusions SIS with good mechanical capability and biocompatibility has been prepared successfully, and then the engineered cardiac tissue has been constructed successfully based on the SIS scaffold.
5.Preparation and Characterization of Berberine Hydrochloride Ternary Complexes
Zhongyi ZHANG ; Panpan ZHANG ; Wenjie ZHANG ; Pinfeng ZHANG ; Ruixin LIU
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(10):2208-2213
The debitterizing effect of ternary complexes was appraised and characterization of ternary complexes was made by infrared spectrum (IR) and differential scanning calorimetry (DSC). The ternary complexes (β-CD/BH/WPI90) of berberine hydrochloride (BH),β-cyclodextrin)β-CD (and whey protein isolate (WPI90) were prepared with adopting coprecipitation preparation. The results showed that the ternary complexesβ-CD/BH/WPI90 can sig-nificantly reduced the bitterness of BH. The content of BH in the ternary complexes was 3.20%. It was concluded that the ternary complexesβ-CD/BH/WPI90 had significant effect in reducing the bitterness of BH. IR and DSC of the ternary complexesβ-CD/BH/WPI90 were different from the simple physical mixture.
6.The effect of Nutritional Risk Screening 2002 on nutritional status and clinical outcomes of liver surgery patients
Wenjing ZHANG ; Qing ZHANG ; Luwen ZHANG ; Ruixin FAN ; Juan HUANG
Parenteral & Enteral Nutrition 2017;24(2):82-85
Objective:To clarify whether nutritional risk screening 2002 could be used as a basis for nutritional support for liver surgery patients.Methods:Among the 243 hospitalized patients,61 patients had ≥ 3 NRS 2002 scores,and 41 of them were given nutrition support.The remaining 182 patients scored < 3,and 73 of them were administrated with nutrition support.Results:The incidence of nutritional risk of hospitalized patients in liver surgery was 25 %.Among the patients at nutritional risk group,67% were given nutrition support.And the rates of infection related complication were nutritional supported patients significantly lower than that in the no nutrition support group (P < 0.05).Conclusion:Accurate application of NRS 2002 and necessary nutrition support in liver surgery patients could improve nutritional status and clinical outcome.
7.Study on the three-dimensional chitosan-decellularised-derma scaffolds for bone tissue engineering
Yan ZHANG ; Ruixin LI ; Xizheng ZHANG ; Yong GUO
Journal of Medical Biomechanics 2010;25(1):11-15
Objective To observe the adhesion of MC3T3-EI osteoblastic progenitor cells to the three-dimensional chitosan-decellularised-derma scaffolds,and evaluate the cytocompatibility of the scaffolds.Method The threedimensional chitosan-decellularised-derma scaffolds were prepared by the freeze-dtying method,the porosity,density and water absorption of which were measured.The microscopic morphology of the composite scaffolds was analyzed by the scanning electron microscopy(SEM).The MC3T3-E1 cells cultivated in vitro were seeded onto the composite scaffolds,and then co-cultured for 2,3,4 and 5 hours.At each time point,three specimens from each matrix were taken to determine the cell-adhesion rate and the best time of the cell-adhesion.The cells were seeded onto the composite scaffolds,and then co-cultured for 1,3,5,7,9,11 and 13 days.The MC3T3-E1 cells inside were evaluated with MTS test.The cell morphology was observed by the histological staining.The compression tests were performed using a Universal Testing Machine,at room temperature,as compared with no-cell-scaffolds.Results The three-dimensional chitosan-decellularised-derma scaffolds have high interval poroslty with the porosity(92.8%),the density(0.09796 g/ml)and the water absorption(2169±100)%.The cytocompatibility test shows that the seeded MC3T3-E1 cells can adhere to the scaffolds and proliferate.Conclusions The three-dimensional chitosan-decellularised-derma scaffolds have high interval porosity with the welldistributed diameter.The MC3T3-E1 cells are easy to adhere the scaffolds and proliferate which shows that the scaffolds have a good cytocompatibility.
8.Utility of diffusion-weighted imaging with background signal suppression in metastatic cervical lymph nodes
Yun ZHANG ; Biling LIANG ; Chuanmiao XIE ; Jinglian ZHONG ; Ruixin YE
Chinese Journal of Radiology 2010;44(10):1041-1044
Objective To prospectively evaluate the value of diffusion-weighted imaging with background signal suppression (DWIBS) in the detection and diagnoses of metastatic cervical lymph nodes. Methods Twenty patients with head and neck squamous cell carcinomas underwent conventional MRI and DWIBS. The ADC values were measured and compared between metastatic and benign lymph nodes. The abilities of DWIBS and conventional MRI in the evaluation of metastatic cervical lymph nodes were compared. Results Conventional MRI demonstrated 101 lymph nodes, in which 58 were diagnosed as metastatic nodes. When MRI criteria were used for discrimination between metastatic and benign nodes, the obtained sensitivity, specificity, accuracy, positive and negative predictive value were 78% (47/60), 81%(44/54), 80% (91/114), 82% (47/57) and 77% (44/57), respectively. The mean ADC values of metastatic nodes (n =60) and benign nodes (n =54) were (0.945 ±0.122) × 10-3 mm2/s and (1. 210 ±0. 151 ) × 10-3 mm2/s ( t = - 10. 354 ,P <0. 01 ). When an ADC value of 1. 090 × 10 -3 mm2/s was used as the threshold for discrimination between metastatic and benign nodes, the obtained sensitivity, specificity,accuracy, positive and negative predictive value were 88% (53/60), 80% (43/54), 84% (96/114), 83%(53/64) and 86% (43/50), respectively. Conclusion DWIBS is helpful in diagnosing metastatic cervical lymph nodes of head and neck squamous cell carcinoma, and is superior to conventional MRI in their detection.
9.Collagen/silk fibroin nerve conduits used for repairing peripheral nerve defect:application and development
Yunqiang XU ; Yingjie LIU ; Ruixin LI ; Shuanglong ZHU ; Zhenhui ZHANG
Chinese Journal of Tissue Engineering Research 2016;20(38):5745-5751
BACKGROUND:Peripheral nerve defect due to limb dysfunction has always been the difficulty faced by the medical profession. Ideal materials and processing technology for constructing a tissue engineering scaffold targeting peripheral nerve repair are stil in research stage. OBJECTIVE:To review the research progress in peripheral nerve repair using col agen/silk fibroin nerve conduits. METHODS:In this paper, the first author retrieved the PubMed and CNKI from 2003 to 2016 to search articles regarding methods of constructing artificial nerve scaffolds and selection of raw materials. Data from these articles were col ected, summarized and analyzed. RESULTS AND CONCLUSION:Forty-six articles were included for final analysis. Col agen and its degradation products trigger no inflammatory response in the host because of high biocompatibility and biodegradability. However, its use is largely limited by its rapid degradation and poor physical performance. Silk fibroin has a high flexibility and biocompatibility, and exhibits a slow degradation in vivo. As a rapid prototyping technique, three-dimensional printing can print various forms of scaffolds within a short time, characterized as high-quality pore structure and large-scale production. Given these, the col agen/silk fibroin nerve conduit prepared using the three-dimensional printing technology can maintain the biocompatibility and even improve the mechanical properties of the raw materials. Until now, more investigations on nerve repair using col agen or silk fibroin have been done, and we have never stopped improving the production process of these scaffolds. Therefore, the col agen/silk fibroin scaffold prepared using the three-dimensional printing technology is expected to become the main candidate for the repair of peripheral nerve defects.
10.The clinical study of comfortable medical with anesthesia in the thyroid surgery
Yan JIANG ; Ruixin HUANG ; Yinshan WANG ; Miqiong HONG ; Yan ZHANG
Chongqing Medicine 2014;(9):1041-1043
Objective To explore a kind of comfortable medical for ervical plexus anesthesia auxiliary anesthesia .Methods 80 thyroidectomy female patients were randomly divided into normal saline group (group A) ,droperidol-fentanyl group (group B) ,bu-torphanol group (group C) ,dex group (group D) ,20 cases in each group .The change of systolic blood pressure (SBP) ,diastolic blood pressure (DBP) ,heart rate (HR) ,blood oxygen saturation (SpO2 ) ,narcotrend index (NTI) were monitored .The above pa-rameters were recorded at 10 min before cervical plexus(T0 ) ,cervical plexus operation(T1 ) ,skin incision(T2 ) ,separation of thyroid upper extreme(T3 )and suture(T4 ) .Results There was no significant difference between the groups A and B at the same time point (P>0 .05) .In group C ,the SBP、DBP、HR at T3 and T4 were significant higher than at T0 ,and at the same point the A and B group decreased statistically significant (P<0 .05) .In group D ,the SBP、DBP、HR at T2 、T3 、T4 were significant lower than at T1 ,espe-cially at T4 compared to at T0 (P<0 .05) .Compared to group A ,B ,C ,the SBP、DBP、HR in group D were lower at T3 and T4(P<0 .05) .NTI in group D at T1 、T2 had significant difference compared with group A and B (P<0 .05) ,especially at T3 、T4 were sta-tistically significant than the other three groups(P<0 .05) ,sedation was better than the other groups .Conclusion Cervical plexus block supplemented by dex can reduce the patient′s stress response and reach moderate sedation analgesia to comfortable medical purposes .