Objective To observe the effects of happy family cognitive training on patients with vascular cognitive impairment. Meth-ods From April, 2015 to April, 2016, 80 patients with vascular cognitive impairment were divided randomly into happy family cognitive training group (n=40) and control group (n=40). Both groups accepted routine medicine and rehabilitation exercise, while the happy family cognitive training group received happy family cognitive training additionally. They were assessed with Montreal Cognitive Assessment (MoCA) and Activities of Daily Living (ADL) before and after 12 weeks of treatment. Results The scores of MoCA and ADL improved more in the family cognitive training group than in the control group after treatment (t>5.454, P<0.001). Conclusion Happy family cogni-tive training is effective on vascular cognitive impairment, for cognitive function and activities of daily living.

To investigate the relationship between SORL1 gene polymorphism and sporadic Alzheimer’s disease（Alzheimer’s disease，AD）.Methods The SNP loci of SORL1 gene rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387 and rs12364988 in 131 sporadic AD patients and 128 healthy controls in Xinjiang were detected by PCR amplification and DNA sequencing. Results There was no significant difference between AD group and control group in the polymorphisms of SNP loci rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387，rs12364988 and rs985421 of SORL1 gene（P>0.05）.Conclusion The polymorphisms of SNP loci rs1010159，rs2282649，rs3824968，rs1699102，rs3781836，rs2070045，rs3781834，rs641120，rs689021，rs668387，rs12364988 and rs985421 of SORL1 gene have no correlation with the pathogenesis of AD.