OBJECTIVE: To study the compatible stability of gatifloxacin for injection in combination with cefathiamidine for injection in 0.9% sodium chloride injection or in 5% glucose injection.METHODS: Changes in appearance and pH value of the mixture of gatifloxcation and cefathiamidine within 8 hours after mixing were respectively observed and determined under room temperature(20?1)℃,and the contents were determined by dual ultraviolet spectrophotometry.RESULTS: The appearance,pH value and contents as well as the ultraviolet absorption peak shape of the mixture showed no significant change within 8 hours after mixing in 0.9% sodium chloride injection or 5% glucose injection.CONCLUSION: Gatifloxacin for injection can be mixed with cefathiamidine for injection in 0.9% sodium chloride injection or 5% glucose injection to use.

OBJECTIVE:To study the compatible stability of gatifloxacin for injection with cefmetazole for injection in 0.9% sodium chloride injection versus in 5% glucose injection.METHODS:The changes in appearance and pH value and UV absorption spectra for the mixture of gatifloxacin for injection with cefmetazole for injection at room temperature(20?1)℃ with 8 hours were observed,and the contents of gatifloxacin and cefmetazole were determined by dual ultraviolet spectrophotometry.RESULTS:No marked change was noted for the mixture within 8 hours in appearance,pH value,contents and UV peak shape.CONCLUSION:Gatifloxacin for injection is compatible with cefmetazole for injection in 0.9% sodium chloride injection or 5% glucose injection.

OBJECTIVE: To explore the causes,patterns and features of drug induced abnormal body temperature.METHODS: 215 articles covering total 1 540 cases of drug-induced abnormal body temperature,published during Jan.1994～ Dec.2005 in 130 Chinese medical journals,were sorted from CNKI and CHKD and consolidated for analysis.RESULTS: Abnormal body temperature cases induced by antimicrobials,traditional Chinese medicines and central nervous system drugs were listed among the top three in number;injections generated the highest proportion of abnormal body temperature cases.Drug-induced abnormal body temperature was not related to sex and age.CONCLUSION: To ensure safe use of drugs,clinicians should inquire about patients' medication history before drug administration,strictly follow medication indications and closely observe the reactions after drug administration.

OBJECTIVE:To study the compatible stability of gatifloxacin for injection and cimetidine injection in 0.9% sodium chloride injection or in 5% glucose injection.METHODS:Changes in appearance and pH value of gatifloxacin in combination with cimetidine within 8 hours after mixing were respectively observed and determined under room temperature(20?1)℃,and the content was determined by UV spectrophotometry.RESULTS:No significant change was seen in appearance and pH value after two hours of mixing of the two agents.But after four hours of mixing,the content of cimetidine went up in both solvents,and its pH value rose slightly in 0.9% sodium chloride injection.CONCLUSION:Gatifloxacin for injection can be mixed with cimetidine injection in 0.9% sodium chloride injection or 5%glucose for injection to use,but the compatible liquid should be used up in 2 hours.

OBJECTIVE:To observe the compatibility of gatifloxacin for injection with cefradine for injection in 5% glucose injection and in 0.9% sodium chloride injection respectively.METHODS:At room temperature for8hours the change in appearance and pH value were observed,while the content was determined by UV spectrophotometry as well.RESULTS:There was no evident change in appearance after the mixture,but the pH value and concentration changed significantly.CONCLUSIONS:There exists incompatibility between gatifloxacin for injection and cefradine for injection.

OBJECTIVE:To study the compatible stability of gatifloxacin for injection with metronidazole disodium phos-phate in sodium chloride injection.METHODS:The contents of2constituents of the mixed solution stored at25℃within8hours was determined by dual ultraviolet wavelength spectrophotometry,and the appearance,pH value of the mixture were compared with those before.RESULTS:There was no significant change in the content of gatifloxacin after mixing,while the content of metronidazole disodium phosphate has a slight reduction,no significant changes were noted otherwise.CONCLUSI_ ON:Gatifloxacin for injection is compatible with metronidazole disodium phosphate in sodium chloride injection if at25℃within4hours'mixing.

OBJECTIVE:To study the compatible stability of gatifloxacin for injection in combination with aciclovir for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS:Changes in appearance and pH value of gatifloxacin in combination with aciclovir within 8 hours after mixing were observed and determined under room temperature(20?1)℃,respectively,and the precipitates in the mixture underwent infrared spectrum analysis.RESULTS:White flocculent precipitate was noted in the mixture within 1 hour of mixing,which was proved as a new substance by infrared spectrum analysis. CONCLUSIONS:There is incompatibility between gatifloxacin for injection and aciclovir for injection.

OBJECTIVE:To study the compatibility of gatifloxacin for injection with famotidine for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS:At room temperature ((20?1)℃)for 8 hours,the changes of the mixture in appearance,pH and UV spectra were observed,and the contents of gatifloxacin and famotidine were determined by ultraviolet spectrophotometry.RESULTS:No significant change was found in pH values and contents within 8h after mixing of the two drugs,nor significant changes were found for the mixture in appearance within 8h in 0.9% sodium chloride injection or within 6h in 5% glucose injection.CONCLUSION: The mixture of gatifloxacin for injection and famotidine for injection were stable in 0.9% sodium chloride injection or 5% glucose injection.

OBJECTIVE:To study the compatibility of gatifloxacin for injection with etamsylate injection in 0.9% sodium chloride injection and 5% glucose injection.METHODS:The appearance of the mixture of gatifloxacin for injection with etams-ylate injection in 0.9% sodium chloride injection and 5% glucose injection at room temperature,i.e.(20?1)℃ within 8 hours was observed,with its pH measured and ultraviolet spectra observed.The contents of gatifloxacin and etamsylate were determined by a dual ultraviolet spectrophotometry.RESULTS:No significant change was noted for the mixture within 8 h in pH and appearance,and the contents of gatifloxacin and etamsylate within 8 h in 0.9% sodium chloride injection or within 6 h in 5% glucose injection showed no obvious change.CONCLUSION:Gatifloxacin for injection can be mixed with etamsylate injection in 0.9% sodium chloride injection or 5% glucose injection.

OBJECTIVE:To disscuss the general regularity and characteristics of drug-induced pathoglycemia.METHO_ DS:1590cases of drug-induced pathoglycemia reported in internal medical journals published from Jan.1994to Jun.2005were collected and analyzed.RESULTS:The drugs that induced pathoglycemia were included chiefly hormone and relate drugs(17species),antimicrobial drugs(13species)and central nervous system drugs(8species),glibenclamide was reported mostly(699cases)and the next was polarized solution(242cases).The most clinical manifestation was the decrease of blood sugar.CONC_ LUSIONS:Clinician should take care of drug-induced pathoglycemia and strengthen the monitor of the level of patient’s bl_ ood suguar in use the drug,to make sure of the safety of the drug.