Eighteen adult rabbits were randomly divided into three groups: normal, control and experimental group. The model of global cerebral ischemia was produced by four-vessel occulsion. The cerebral temporal cortex samples were collected to determine volume of the water, LPO and Ca~(2+) concentration,SOD activity,and pathologic examinations of the cortex were made by optical and electronic microscope. The results showed that fructose-1, 6-diphosphate (FDP) reduced the water content and intracellular Ca~(2+)level, restrained the LPO production, enhanced the SOD activity of the brain. It is concluded that FDP protects cerebral biological membrane to a certain degree from ischemia and reperfusion injury.

Objective To explore clinical value of tumor specific growth factors (TSGF) in serum and bronchoalveolar lavage fluid (BALF) on differential diagnosis of benign and malignant periphery solitary pulmonary nodules (PSPN). Methods Serum and BALF from both normal and afflicted side were collected from 211 patients with PSPN(case group) and from 196 patients without any type of tumor (control group). TSGF and carcinoembry-onic antigen (CEA) in serum and BALF were measured in both groups. Results In the malignant PSPN patients, CEA in serum, normal and afflicted side were 28.73 (SD: 15.61) μg/L,63.31 (SD:21.28) μg/L and 85.54(SD: 26.19)μg/L,respectively, which was significantly higher than that of the benign PSPN patients (7.21(SD:2.43) μg/L, 12.36(SD:6.93)μg/L and 14.65 (SD:8.07)μg/L,respectively), as well as that of the control group (4.68 (SD: 1.25) μ/L and 11.06(SD:8.03) μg/L in serum and BALF, respectively (P < 0.05). TSGF in the serum and BALF from the normal and afflicted side of malignant PSPN patients was 88.73 (SD:13.51)μg/L, 110.73 (SD: 18.64) μg/L and 162.80(SD:58.89) μg/L, respectively, which were significantly higher than that of the benign PSPN patients (56.31(SD: 2.43) μg/L, 79.25 [SD: 36.86] and 86.29 (SD: 37.07) μg/L, respectively) (P <0.05). Furthermore, in the malignant PSPN patients, TSGF and CEA in the afflicted side were significantly higher than that of the normal side. Sensitivity, specificity and accuracy of TSGF in BALF from the afflicted side for malig-nant diagnosis were 86.6%,100.0% and 98.6%,respectively,which was higher than that of CEA (70.2% ,78. 9% and 76.5% respectively) and that of serum TSGF (73.1% ,88.9% and 85.7% respectively). Conclusions TSGF in bronchoalveolar lavage fluid and serum has a significant role in differential diagnosis of benign and malig-nant periphery solitary pulmonary nodules. Furthermore, measurement of TSGF in bilateral BALF is helpful in diag-nosis of tumor location.

ObjectiveTo explore the relationship among the aggressive behavior,hostile attribution bias and childhood trauma in schizophrenic patients.Methods 135 schizophrenic patients were tested with Modified Overt Aggression Scale (MOAS),the Chinese-version of the Ambiguous Intentions Hostility Questionnaire (AIHQ-C) and Childhood Trauma Questionnaire (CTQ).According to the score of the MOAS,the patients were divided into the aggressive group ( n =58 ) and the non-aggressive group ( n =77 ).The hostile attribution bias and the childhood trauma were compared between the two groups,and correlation and hierarchical regression analysis were used to investigate the relationships of the variables.ResultsCompared with the non-aggressive patients,the aggressive patients had significantly higher AIHQ-C total hostility bias score (6.27 ± 1.20 vs 5.90 ± 0.97,P ＜0.05 ),total blame bias score (8.04 ± 1.97 vs 6.91 ± 2.10,P ＜ 0.01 ) and total aggression bias score ( 6.17 ±1.02 vs 5.59 ± 1.04,P ＜ 0.01 ).Correlation analysis showed that the MOAS score,AIHQ scores and the total score of CTQ were significantly positively correlated with each other ( r =0.171 ～ 0.350,P ＜ 0.05 ～0.01 ).Regression analysis indicated the hostile attribution bias directly predicted the aggressive behavior( β =0.342,P ＜0.05) and completely mediated the relationship between the childhood trauma and the aggressive behavior.ConclusionThe aggressive behavior in schizophrenic patients is associated with the experience of childhood trauma and the attribution style.The childhood trauma indirectly influences the aggressive behavior by the mediating of the hostile attribution bias.

Objective To explore the effects of self-efficacy theory on coping style and quality of life of patients with bladder cancer underwent the targeted therapy.Methods A total of 84 advanced bladder cancer patients in our hospital from May 2011 to May 2016 were selected in the study using convenience sampling method. All patients were randomly divided into control group and observation group,each 42 cases. Patients in both groups were given the combination of conventional chemotherapy and targeted therapy with trastuzumab intravenous injection. The therapy was observed for 4 cycles. Patients in the control group were given routine nursing during the treatment, while patients in the observation group received additional nursing intervention based on self-efficacy. The prognosis and curative effect, coping style and quality of life scores of patients were recorded in the two groups.Results The total curative effective rate of patients in the observation group was 52.38%, which was higher than that in the control group (28.57%). The difference was statistically significant between two groups (P<0.05). After the intervention, the positive coping scores of two groups significantly increased (P<0.05), while the negative coping scores significantly decreased (P<0.05). The changes in the observation group was significantly better than that in the control group (P<0.05). The average quality of life score of the observation group after the intervention was significantly higher than that of the control group (P<0.05).Conclusions The application of self-efficacy theory in the bladder cancer patients underwent the targeted therapy can promote the transformation of positive coping style and improve the quality of life of patients, which is beneficial to the improvement of the overall total effectiveness.

Objective To explore how to achieve isolation of clinical trial fees and general medical expenses of hospitalized subjects through information technology.Methods This article analyzed various methods for separating clinical trials fees from medical insurance and suggested that all methods need to protect subjects'medical insurance reimbursement rights and ensure that they do not occupy medical insurance funds.Based on this principle,A clinical trial cost segregation information module was developed based on inpatient's workstation.Results Through this information module,subjects could choose their medical status according to the actual medical situation.Doctors could issue medical orders in hospital information system(HIS)according to normal medical or trail needs,change the nature of the orders by adding or deleting clinical trial tags.The system automatically intercepts the clinical trial orders for reimbursement of medical insurance,while other expenses are reimbursed according to rules of medical insurance.Conclusion The application of this information module has improved the subjects'enthusiasm and compliance to participate in clinical trials,reduced their economic burden,and ensured their rights to enjoy reimbursement of medical insurance,which can be used as a reference example for newly registered clinical trial institution.

Objective:To evaluate the arthroscopy-assisted reduction and internal fixation (ARIF) via the traditional anterolateral approach for the treatment of posterolateral tibial plateau fractures (PTPF).Methods:A retrospective study was conducted of the 79 patients with PTPF who had been treated from March 2014 to February 2020 at Department of Articular Surgery, Linyi Central Hospital. They were 37 males and 42 females, aged from 17 to 71 years (average, 46.0 years). According to treatment methods, they were assigned into an ARIF group (37 cases) and a control group (42 cases). The ARIF group was treated by ARIF via the traditional anterolateral approach and the ARIF varied according to the extents of articular collapse and split and displacement of fracture fragments. The control group was treated by traditional reduction and internal plate fixation of the proximal tibia. The 2 groups were compared in terms of operation time, blood loss, iliac bone grafting, hospitalization time, follow-up time, Hospital for Special Surgery (HSS) score, maximum flexion and extension, fracture healing time, Rassmussen functional and anatomical scores, visual analogue scale (VAS) pain score and complications.Results:There was no statistically significant difference in the general data between the 2 groups, showing comparability ( P>0.05). All patients were followed up for 6 to 18 months (average, 11.4 months). The operation time [(48.9±8.2) min], blood loss [(73.1±20.8) mL], hospitalization time [(9.3±2.5) d], and fracture healing time [(12.5±1.8) weeks] in the ARIF group were all significantly less than those in the control group [(55.2±9.9) min, (100.8±30.3) mL, (11.8±2.8) d and (15.1±2.1) weeks] while the HSS score [(93.5±4.6) points], maximum flexion angle (107.8°±10.4°) and Rassmussen functional score [(27.1±1.8) points] in the ARIF group were significantly higher than those in the control group [(88.4±7.4) points, 100.4°±10.0° and (26.1±2.4) points] (all P<0.05). There was no significant difference between the 2 groups in iliac bone grafting, follow-up time, maximum extension angle, Rassmussen anatomical score, VAS score, or rate of complications (all P>0.05). Conclusions:Compared with traditional surgery, ARIF which varies with the extents of articular collapse and split and displacement of fracture fragments may lead to shorter operation time, reduced surgical trauma and more accurate reduction of the articular surface. Therefore, it can be an additional choice in the treatment of PTPF.