The theory of ascending and descending activities of qi is one basic theory that guides diagnosis and treatment of disease clinically. It has been esteemed by ancient physicians throughout their academic thinking and clinical diagnosis. As a kind of unbalanced disease in the whole body, the basic internal mechanism of tumor formation may be caused by unbalanced ascending and descending activities of qi. Better clinical efficacy is liable to get by applying the theory of ascending and descending activities of qi in cancer treatment. Therefore, we hope to provide a reference for clinicians from the following aspects: historical status and academic value of the theory of ascending and descending activities of qi, case examples and classical prescriptions.
Humans ; Neoplasms ; diagnosis ; therapy ; Qi

Objective To explore the value of characteristic manifestation of diffusion-weighted images at 3.0T MR system in cer-ebral disease.Methods 120 patients with cerebral disease diagnosed by MR diffusion-weighted images (fat suppression effect,T2 blackout effect,T2 shine-through effect,T2 washout effect)underwent routine MR scan,including echo planar imaging-diffusion weighted imaging (EPI-DWI)and apparent diffusion coefficient (ADC)map,whose characteristic manifestations of DWI were retro-spectively analyzed.Results 1 5 cases of lipoma and 8 cases without fat lesions were diagnosed with fat suppression effect.13 cases of acute cerebral hematoma,1 1 cases of hemorrhagic cerebral infarction and 1 6 cases of micro bleeding of missed diagnosis or small cavernous hemangioma were diagnosed with T2 blackout effect.1 5 cases of epidermoid cyst,5 cases of choroid plexus cyst were di-agnosed with T2 shine-through effect.1 5 cases of posterior reversible encephalopathy syndrome and 22 cases of brain tumor were di-agnosed with T2 washout effect.Conclusion Comprehensive use of the characteristic manifestation of EPI-DWI and ADC map can help the diagnosis of cerebral disease.

As a characteristic tumor therapy in China, Chinese medicine (CM) plays an important position in comprehensive treatment of tumor. It's a critical issue of objective realization, analysis and evaluation of CM safety for scientific decision-making in tumor safe medication and it also is a pivotal issue which affects the international communication. The safety evaluation of CM includes three phases: pre-clinical safety evaluation, clinical trials (micro-dose studies and traditional clinical trials) and post-marketing CM safety assessment. The key point of evaluation should be distinguished among different stages and various types of CM (such as classic formulas, Chinese herbal extracts, etc). Emphasis should be given to chronic toxicity when evaluating oral Chinese herbal , microdose studies and quality control must be underlined while injection is evaluated and more attention should be pay to the dose-effect relationship and time-effect relationship when turned to toxic Chinese medicine , and so as for the toxicity grading study. Moreover, we should constantly improve CM safety assessment method in various stages of tumor treatment, such as introducing the concept of syndrome classification theory, bringing in metabonomics and real-world research method which are similar to the CM therapeutic concept. Most importantly, we must keep its own feature of CM theory when we learn the concept of safety evaluation from abroad. Actively exploring the anti-tumor medicine safety evaluation methods and strategies is of great significance for clinical and experimental research, and it can provide supportability platform to CM's international communication.
Animals ; Combined Modality Therapy ; Humans ; Medicine, Chinese Traditional ; adverse effects ; methods ; Neoplasms ; therapy ; Safety

Objective To analysis the outcome of gastroscopy and B ultrasonography in patients of post hepatitis cirrhosis with portal hypertension, and to evaluate the degree of cirrhosis in clinic and affording suggestions in preventing complication. Methods One hundred and ninety two cirrhosis patients with portal hypertension were divided into three groups : mild, moderate and severe group based on the extent of esophageal varicosis. By estimating the diameter of portal vein, thickness of spleen and width of splenic vein in three groups to investigate their correlation with the extent of cardio-esophageal varicosis. Results The incidences of gastric varices in these three groups have prominent difference,The severer the degree of esophageal varices , the higher the incidence of gastric varices. According to the different degree of esophageal varices, the diameter of portal vein,thickness of spleen,diameter of splenic vein are differed. There is linear relation between thickness of spleen and diameter of splenic vein. Conclusion Diameter of portal and splenic vein, thickness of spleen,can provide valuable suggestion in predicting the presence of portal hypertension,but further confirmation is based on the result of gastroendoscopy.

Objective To compare patient radiation dose of two techniques of spine X-ray panoramic imaging under the same image quality.Methods An anthropomorphic phantom was used.The reasonable imaging parameters were found for spine panoramic radiography using Sonialvision safire17 Slot scan with HQ mode.And the panoramic films were obtained with different parameters using GE XR650 DR system.The panoramic images were scored by three experienced radiologists.The imaging parameters with the same score in groups were input into PCXMC 2.0 software to get effective dose(E) and organ dose.Results The reasonable imaging parameters of Slot scan were high quality(HQ) mode, SID 150 cm, 100 kVp, and 2 mAs;and the corresponding parameters of XR650 were SID 200 cm, 100 kVp, and 3.2 mAs.The E of the Slot scan with HQ mode, XR650 with manual mode and XR650 with AEC mode was(0.118 7±0.001 4),(0.0847±0.0008), and (0.1580±0.001 5) mSvrespectively, while the E of XR650 with manual mode was lower than the others(F =3 007.293, P ＜0.05).The organ dose using XR650 DR with manual mode were lower than that using Slot scan with HQ mode in all samples except breasts(P ＜0.05);the organ dose using XR650 DR with AEC mode were higher than that using XR650 DR with manual mode and Slot scan with HQ mode for all samples except for thyroid, oesophagus and lungs (P ＜0.05).Conclusions The radiation doses of both spine X-ray panoramic imaging with manual mode are low, and low dose spine X-ray panoramic imaging can be achieved if reasonable parameters are used.

Adrenal Cortex Hormones ; therapeutic use ; Antitubercular Agents ; therapeutic use ; Diagnosis, Differential ; Humans ; Sarcoidosis ; drug therapy ; epidemiology ; microbiology ; pathology ; Tuberculosis ; drug therapy ; epidemiology ; microbiology ; pathology

Adolescent ; Child ; Child, Preschool ; Female ; Hepatocyte Growth Factor ; metabolism ; Humans ; Kidney ; metabolism ; pathology ; Male ; Nephrotic Syndrome ; metabolism ; pathology ; Proto-Oncogene Proteins c-met ; metabolism

Objective To investigate the influence of high-voltage electrical burn on the throm-bomodulin (TM), protein C (PC), protein S (PS) and D-Dimer (D-D) in SD rats. Methods One hundred and twenty healthy SD rats were divided into the fake high-voltage electrical burn groups (FHEB), high-voltage electrical burn groups (HEB) according to the random number table, with 60 rats in each group. Ten rats were taken from each group at 15 minutes before injury. Plasma were collected from heart blood. Fifty SD rats of HEB group with voltage regulator and experimental transformer. The remaining fifty SD rats of FHEB group were sham injured with the same devices without electric current. At 5 minutes and 1, 2, 4, 8 hour (s) post injury, 10 rats of every group were randomly chosen at each time point for observation of the concentrations of TM, PC, PS and D-D. Plasma were collected from heart blood. Data were processed with analysis of variance of factorial design and LSD test. Results Compared with the FHEB group, the concentration of TM from 5 minutes to 8 hours post injury in HEB group was higher significantly (P < 0.05). Exception of the concentrations of PC and PS at 15 minutes before injury, the concentrations of PC and PS were lower than those of FHEB group (P < 0.05). The concentration of D-D in HEB group peaked at 8 hours post injury in (173.05 ± 4.08) ng/mL. Conclusion High-voltage electrical burn at early stage can increase the concentrations of TM, D-D, as well as decrease the concentrations of PC and PS, which are not only causing the vascular endothelium damage but also possessing serious effect on the thromboplastin function of SD rats.

Objective To study the CT perfusion features of various lymph nodes in the neck.Methods Dynamic perfusion CT scanning was performed in 83 neck lymph nodes proved by pathology,including tuberculosis lymph nodes, lymphoma and metastatic lymph nodes. The shapes, blood flow modes,and perfusion parameters of these lymph nodes were compared among 3 groups. Statistical analysis of L/T and CT perfusion parameters was performed by one-way ANOVA and LSD test. Results The values of MTT of tuberculosis lymph nodes, lymphoma and metastatic lymph nodes were (28. 13 ±5.08), (31.08 ±5.82),and ( 11.24 ±5.31 ) s,respectively. The MTT of metastatic lymph nodes was statistically lower than that of tuberculosis lymph nodes and lymphoma (P ＜ 0. 05). Their frequencies of marginal blood flow were 5/9,4/19, and 39/55 (70. 9% ), respectively. The frequency of marginal blood flow in the tuberculosis lymph nodes and metastatic lymph nodes was statistically higher than that of lymphoma ( P ＜ 0. 05 ). Their frequencies of central blood flow were 2/9, 11/19, and 9/55 (16.4%), respectively. The frequency of central blood flow in the lymphoma was statistically higher than that of tuberculosis lymph nodes and metastatic lymph nodes ( P ＜ 0. 05 ). Their values of L/T were 1.82 ± 0. 32, 1. 80 ± 0. 39, and 1.84 ± 0. 36,(40. 98 ±6. 62) s,respectively. There were no significant differences in L/T, BF, BV and TTP among tuberculosis lymph nodes, lymphoma and metastatic lymph nodes( P ＞ 0. 05 ). Conclusion CT perfusion,especially combination functional imaging with perfusion images may be helpful in judging the nature of neck lymph nodes.

Recent studies have demonstrated an association of glucagon-like peptide-1 (GLP-1) signaling defect with non-alcoholic fatty liver disease (NAFLD).Native GLP-1 and GLP-1-based agents may directly act on hepatocytes through activation of GLP-1 receptors in hepatocytes,resulting in the regulation of gene expression associated with insulin resistance and lipid metabolism,and the suppression of oxidative stress in liver cells.Moreover,GLP-1-based agents have been reported to be effective in improving hepatic endpoints in patients with NAFLD.