Objective:To observe the clinical curative effect of narrow-band UVB-LED (308nm) combined with tacrolimus, narrow-band UVA-LED (365nm) combined with 8-Methoxypsoralen irradiation in the treatment of vitiligo.Methods: Sixty-four cases of vitiligo patients were chosen and randomly divided into control group and observation group, each group with 32 cases. The control group received 308nm narrow-band UVB-LED irradiation combined with tacrolimus,the observation group received 365nm narrow-band UVA-LED irradiation combined with 8-Methoxypsoralen, the time of appreance of the first pigment island in patients were compared between the two groups,the clinical curative effect of both groups were observed when treated with 10 times and 20 times.Results: The average irradiation times when first pigment island appreance in the observation group and the control group were 5.59 and 6.24 respectively, the difference was not statistically significant (t=1.772,P>0.05). The efficiency rate of the control group was 37.50% after 20 times treatment, and in the observation group was 40.63%, the difference was not statistically significant (x2=0.000,P>0.05).Conclusion: 308nm narrow band UVB-LED combined with tacrolimus and 365nm narrow-band UVA- LED combined with 8- Methoxypsoralen irradiation in the treatment of vitiligo have significant treatment effects, how to improve the treatment effect still need further study.

Systemic lupus erythematosus is an autoimmune-mediated inflammatory diseases in which immunologic derangement throughout this process.There are a varriety of abnormal immunoregulation,including the disturbance of Help T cell 1,Help T cell 2,Th17 cell and regulatory T cell( Treg cell),disfunction of the B cell subsets and deficiency of the immune tolerance,lead to the disturbance of related cytokines.Recently,it was indicated that the abnormal of cross regulation existencd between Help T cell 1 and Th17 cell,and the disfunction of non-antibody-dependent B cells may play an important role in the pathogenesis of SLE,According to different immune status,appropriate and targeted treatment was given in order to improve the prognosis of the patients with systemic lupus erythematosus.

Rotavirus(RV) is the leading pathogen of acute gastroenteritis in children,accounting for approximately 5 ％ of deaths worldwide.By now,no specific antiviral treatment is available for rotavirus infection.The duration of passive immunization is shorter than active,so oral immunoglobulin for prevention and treatment of rotavirus might not be the best strategy.Currently,two rotavirus vaccines-Rotarix and RotaTeq are licensed and used in many countries,and they have been recognized as powerful weapons to combat deaths from acute gastroenteritis.The trials of interventions,such as oral rehydration,zinc preparations,probiotics and nitazoxanide are testified to be effective for some young children with acute gastroenteritis.This paper reviews the progress of prevention and treatment of rotavirus infections in children.

Alpha-fetoprotein (AFP) was first discovered over 50 years ago, and is currently applied clinically in diagnosis, effects evaluation and relapse judgement of tumors especially for the primary hepatocellular carcinomas.And as an effective tumor marker, AFP test has become one of the essential items in physical examination.However, its clinical application is not limited to primary hepatocellular carcinomas,and its great application value has been proved in many benign diseases and other tumors (non-hepatic carcinomas).

Objective To understand ureaplasma urealyticum(Uu)and mycoplasma hominis(Mh)infection and drug resistance of mycoplasma from infertility patients in Lanzhou,to direct the clinical use of antibacterial drugs.Methods Uu and Mh from 1 278 cases were cultered and tested as well as their drug resistance were analyzed.Results 42.9%infertility patients showed Uu positive,7.0% showed Mh positive,and 9.0% infertility patients were mixed infection of both Uu and Mh.The sensitive antibacterial drugs were josamycin,doxycycline,minocycline hydrochloride,and clarithromycin,which the sensitive rates of both Uu and Mh were>80%,however,the sensitive rates of Uu and Mh against ciprofloxacin were 11.3% and 16.0%,respectively.Conclusion The mycoplasma infection rate was high in infertility patients,and the problem of drug resistance was serious.The results of drug sensitivity analysis should be recognized as a guide for rational drug use.

The intestinal mucosa is the biggest lymph organ in human body, which consists of the first line of defensive system with the respiratory mucosa and urinary mucosa. The intestinal mucosa is responsible to defend bacteria, viruses, dietary pathogens, non-steroid anti-inflammatory drug and so on. If the intestinal mucosal immune system is destroyed, the human will suffer many diseases such as infectious diseases,autoimmune diseases. Therefore, it plays an important part in physical health. T helper type 17 (Th17) cells different from Th1 cells and Th2 cells are a distinct lineage of T cells. The discovery of Th17 cells has ruined the constitutional pattern of Th1/Th2. Th17 cells, which are important parts of intestinal mucosal immune system,play critical roles in intestinal autoimmune diseases, tissue inflammation and the infection of various pathogenic bacteria. This paper will review the differentiation of Th17 cell and its function in intestinal mucosal barrier,intestinal autoimmune diseases and intestinal infectious diseases.

Objective To compare the efficacy of continuous positive airway pressure (CPAP) with that of surgical treatment for obstructive sleep apnea-hypopnea syndrome (OSAHS) in elderly patients. Methods Seventy patients with OSAHS were divided into a study group and a control group according to different treatment methods. The study group received CPAP, while the control group underwent surgical treatment. One month after treatment, apnea-hypopnea index (AHI), lowest oxygen saturation (LSaO2), ESS scale value, coagulation factors, and platelet count were measured in both groups. Results AHI and LSaO2 were lower and ESS scale value was higher in the study group than in the control group, but with no significant differences (P>0.05). After treatment, all the indexes of coagulation factors were increased in the control group, but only plasma clotting factorⅡactivity had a significant statistical difference (P<0.05); (FⅡ: C) and (FⅧ: C) were significantly lower in the study group than in the control group (P<0.05); platelet count significantly increased in the control group (P<0.05), but markedly declined in the study group (P<0.05). Conclusions Both CPAP and surgical treatment have a better effiacy for obstructive sleep apnea-hypopnea syndrome. CPAP can more effectively improve coagulation function and lower the risks of complications.

The procedure of treating prostate cancer is as the following: After local prostatectomy or radiotherapy or local palliative therapy, androgen-dependent prostate cancer(ADPC) should be given first-line endocrinal therapy. Almost all patients will be developed from ADPC to hormone independent prostate cancer (HIPC) after 14 ～ 30 months, including androgen-independent prostate cancer(AIPC) and hormone-refractory prostate cancer(HRPC). Second-line endocrinal therapy and chemotherapy should be given, respectively. Antibone metastasis therapy is given when bone metastasis occurred. All medical methods should be used rationally and comprehensively to improve the management of prostate cancer.

Certain specific cancer stem cell subpopulation has been isolated from many kinds of tumors by some specified cell surface maker, including myeloma, lung carcinoma, colon cancer, prostate cancer and pancreatic carcinoma. However, poor individual specificity of cell surface maker molecules and heterograft-related problems provoke more researchers to find more specified cell surface makers and establish humanized mice receptor model in the future. From a clinical perspective, tumor stem cells are considered to be the potential target for curing cancer. Research advances in tumor stem cells can help us to elucidate the close relationship between tumor stem cells and tumorigenesis and provide new ideas and alternative pathways for us to conquer the tumor and avoid tumor recurrence and metastasis.

Objective To observe the clinical effect of poractant alfa injection(curosurf)combined with nasal continuous positive airway pressure(CPAP)in the treatment of neonatal respiratory distress syndrome(NRDS). Methods Fifty patients of infants with NRDS were divided into 25 cases of observation group(curosurf combined with CPAP)and 25 cases of control group(CPAP)according to the methods of the treatment.The differences in treatment efficacy rate and arterial blood gas index were compared.Results The efficacy rate of the observation group (88%)was higher than that of the control group(56%),the difference between the two groups was statistically significant(χ2 =4.861,P <0.05 ).After the treatment,the arterial blood gas index of the observation group were improved obviously compared with that before the treatment,the differences were statistically significant(all P <0.05).After the treatment,the arterial blood gas index of the control group were improved obviously compared with that before the treatment,the differences were statistically significant(all P <0.05).After treatment,the differences in pH value,PaO2 and PaCO2 of the observation group were statistically significant compared with the control group(t =6.00,8.49,4.46,all P <0.05).Conclusion Poractant alfa injection combined with nasal CPAP in the treatment of NRDS is better than using CPAP alone.