The bactericidal activity of serum and cere brospinal fluid (SBA and CBA)of ceftroiaxone (CTRX), cefotaxime(CTX) cefuroxime(CFR) in the patients undergoing surgery of skull and brain were studied by means of microdi luted method. The results showed antibacterial activity of CTRX against, enterobactericeae in vitro or in serum and cerebrospinal fluid (CSF) was the highest, it is suggested that the schadule of CTRX per 12hr may be used in prevention and treatment of serious infections after surgery of skull and brain.The bacteria The SBA and CBA of CFR were less ,but its antibacterial spectrum was wide and bactezi cidal activity of CTX against gram positive strains and enterobactericeae in sencm and CSF were higher, CTX may be used in treatment of infections of nervous system caused by mixed bacteria, the cost was lower, so CFR may be selected in the moderate infections. The CBA was a synthesized guide reflexing the antibactieral activity and penetration into barrier, so it is impostand reference to select antibiotics of infection after surgery of skull and brain.

MIC,according to which,the antibiotics frequently used for treating respiratory infections were divided into three groups:Time-dependent(with minimal or no PAE),Concentration-dependent(with PAE),Time-dependent and Concentration-enhanced(with PAE),In addition,the most appropriate antibiotic administration methods are also explored respectively in the article.Finally,several measures of preventing emergence of resistance are proposed based on the theory of MPC.

The procedure of treating prostate cancer is as the following: After local prostatectomy or radiotherapy or local palliative therapy, androgen-dependent prostate cancer(ADPC) should be given first-line endocrinal therapy. Almost all patients will be developed from ADPC to hormone independent prostate cancer (HIPC) after 14 ～ 30 months, including androgen-independent prostate cancer(AIPC) and hormone-refractory prostate cancer(HRPC). Second-line endocrinal therapy and chemotherapy should be given, respectively. Antibone metastasis therapy is given when bone metastasis occurred. All medical methods should be used rationally and comprehensively to improve the management of prostate cancer.

0.05; emphysema in animals inhaling diphosgene into lower rispiratory tract (LRT) alone was obvious with Pden (0.59?0.05) being different from that of control animals, P

Adult ; Aged ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Occupational Exposure ; Pneumoconiosis ; diagnosis ; epidemiology ; Welding

Biomedical Research ; Humans ; Integrative Medicine ; Medicine, Chinese Traditional

Objective To observe the effect of valsartan combined with salvia miltiorrhiza ligustrazine in treating early diabetic nephropathy(DN),looking for an effective method for the treatment of early DN.Methods 51 DN patients were divided into two groups,28 cases in the treatment group were treated with valsartan and salvia miltiorrhiza ligustrazine therapy,23 cases in the control group only received valsartan treatment.Fasting blood glucose before and after treatment (FPG),2h postprandial blood glucose (2hPG),glycosylated hemoglobin (HbA1 c),BUN,Scr,urine albumin excretion rate(UAER) index were detected.Results Before and after treatment,FPG,2hPG,HbA1c,UAER in the two groups had statistically significant differences (t =5.361,6.458,3.026,7.894,5.648,7.604,6.590,8.652,all P ＜ 0.05).After treatment,2hPG,HbA1c,UAER between the two groups had statistically significant differences (t =3.125,3.520,3.881,all P ＜ 0.05).No statistical difference was observed before and after treatment in two groups of BUN,Scr (P ＞ 0.05).Conclusion Valsartan combined with salvia tetramethylpyrazine in treatment of early DN was more effective than single valsartan treatment,and no significant adverse reactions was found in combined treatment.Therefore,the combined treatment can be used as a new method for clinical treatment of early DN.

High mobility group protein A1 ( HMGA1 ) are members of a superfamily of non-histone chromatin proteins,which exist widely in eukaryotic nuclei and are mainly involved in transcriptional regulation of gene expression.Recent researches show that almost all human malignant tumors have abnormal expression of HMGA1,which may have an important role in the development of cancer,but the exact mechanism is not clear yet.In cancer research,transfection system which constructed on the basis of HMGA1 will have potential value,and also could shed some light on the treatment of cancer.

Individualized Quality Control Plan ( IQCP) is a method of quality control for total testing process.In January 2016, the United States formally adopted the IQCP instead of the original equivalent quality control.This article will introduce how to establish and implement IQCP in the laboratory , and discuss the common problems in the process of its application .

AIM: To investigate the antimicrobial activity of linezolid,vancomycin and other antibacterials against 111 methicillin resistant staphylococcus aureus.METHODS: Broth dilution method was used to determine the minimum inhibitory concentrations(MICs) of linezolid,vancomycin and other antibacterials against 111 methicillin resistant staphylococcus aureus identified by cefoxitin.RESULTS: The resistant rates of 111 MRSA to ?-lactam,erythromycin,aminoglycosides(netilmicin and gentamycin),fluoroquinolones(gatifloxacin,moxifloxacin and levofloxacin) and chloromycin were 100%,92.8%,99.1%,91.9%-99.1%,3.6%.All 111 MRSA were sensitive to linezolid and vancomycin,and MIC50 and MIC90 of vancomycin were 0.5 and 1 ?g/mL,MIC50 and MIC90 of linezolid were 2 ?g/mL.CONCLUSION: 111 MRSA were resistant to most antibacterials including ?-lactam,erythromycin,aminoglycosides and fluoroquinolones.Linezolid and vancomycin have strong antimicrobial activity against MRSA.