Objective:To observe the clinical curative effect of narrow-band UVB-LED (308nm) combined with tacrolimus, narrow-band UVA-LED (365nm) combined with 8-Methoxypsoralen irradiation in the treatment of vitiligo.Methods: Sixty-four cases of vitiligo patients were chosen and randomly divided into control group and observation group, each group with 32 cases. The control group received 308nm narrow-band UVB-LED irradiation combined with tacrolimus,the observation group received 365nm narrow-band UVA-LED irradiation combined with 8-Methoxypsoralen, the time of appreance of the first pigment island in patients were compared between the two groups,the clinical curative effect of both groups were observed when treated with 10 times and 20 times.Results: The average irradiation times when first pigment island appreance in the observation group and the control group were 5.59 and 6.24 respectively, the difference was not statistically significant (t=1.772,P>0.05). The efficiency rate of the control group was 37.50% after 20 times treatment, and in the observation group was 40.63%, the difference was not statistically significant (x2=0.000,P>0.05).Conclusion: 308nm narrow band UVB-LED combined with tacrolimus and 365nm narrow-band UVA- LED combined with 8- Methoxypsoralen irradiation in the treatment of vitiligo have significant treatment effects, how to improve the treatment effect still need further study.

Objective To compare the efficacy of continuous positive airway pressure (CPAP) with that of surgical treatment for obstructive sleep apnea-hypopnea syndrome (OSAHS) in elderly patients. Methods Seventy patients with OSAHS were divided into a study group and a control group according to different treatment methods. The study group received CPAP, while the control group underwent surgical treatment. One month after treatment, apnea-hypopnea index (AHI), lowest oxygen saturation (LSaO2), ESS scale value, coagulation factors, and platelet count were measured in both groups. Results AHI and LSaO2 were lower and ESS scale value was higher in the study group than in the control group, but with no significant differences (P>0.05). After treatment, all the indexes of coagulation factors were increased in the control group, but only plasma clotting factorⅡactivity had a significant statistical difference (P<0.05); (FⅡ: C) and (FⅧ: C) were significantly lower in the study group than in the control group (P<0.05); platelet count significantly increased in the control group (P<0.05), but markedly declined in the study group (P<0.05). Conclusions Both CPAP and surgical treatment have a better effiacy for obstructive sleep apnea-hypopnea syndrome. CPAP can more effectively improve coagulation function and lower the risks of complications.

MIC,according to which,the antibiotics frequently used for treating respiratory infections were divided into three groups:Time-dependent(with minimal or no PAE),Concentration-dependent(with PAE),Time-dependent and Concentration-enhanced(with PAE),In addition,the most appropriate antibiotic administration methods are also explored respectively in the article.Finally,several measures of preventing emergence of resistance are proposed based on the theory of MPC.

Dengue virus receptor is one of the hot issues in the investigation of dengue virus.The structures of many receptors,such as proteins,Fc-R,heparin sulphate and LPS/CD14-associated binding proteins,have been confirmed.Recently,great progress has been made in the research of some special receptors found in cells suseptible to dengue virus,and protein compositions binding to the virus membrane domain have been isolated from several susceptible cell lines.The candidates for the composition of the receptor can be catergorized into heat-shock protein,glucose regulated protein,laminin receptor,DC specific ICAM-3 grabbing non-integrin,etc.This article reviewed the recent advancements in the study of dengue virus receptors.

Objective In order to investigate the ability of flow cytometer (FCM) to diagnose malignant tumor and evaluate prognosis of tumors in salivary glands, the DNA ploidy and cell cycle had been analysed and the association of these parameters with histologic grades, lymph node metastasis were studied. Methods The fresh tissues of benign tumor, mixed tumor and malignant tumor were detected by FCM. Results DNA aneuploid has not been detected in benign tumors; 44 cases of mixed tumor has been detected with DNA aneuploid nd with high SPF; it suggests that these cases have malignant trend; most of malignant tumor were detected with high aneuploid. DI was not correlated with lymph node metastases, but correlated with histologic grades (P

0.05).Conclusion:QDs show no effect on cytobiological behavior of living MG-63 cells.

Objective:Assessment ofthe value of B-type natriuretic peptide levels combines TIMI risk scores in predictinglate mortality in patients with ST-segment Elevation Myocardial Infarction(STEMI).Methods:345 patients with STEMI were studied.Blood was drawn and the plasma concentration of BNP was determined within 24 hours after the onset of chest pain and the patients'TIMI risk score was measured.The all-cause mortality,including cardiac and non-cardiac deaths during Long-term follow-up,was recorded.Results:Mortality was 20.0%(n=69)during a follow-up of 314?208 days.The late mortality was related to higher TIMI risk scores(P;P

The mechanism of hypotensive effect of siiybin was studied in anesthetized cats and rats. The results show that the hypotensive action caused by siiybin is not central in origin, and not related to the effect of autonomic nervous system and the release of histamine and prostagiandin, but is mainly due to vasodilation.

Pathological changes of Kupffer cells in number and ultrastructure were studied by means of colloidal carbon uptake, endogenous peroxidase cytochemistry, quantitative histology and ultrastructural stereologic morphometry at various time intervals (3,7,14,21,and 28 d) after common bile duct ligation. Kupffer cell phagocytic function and serum fibronectin opsonic activity were measured. The results show the morphological changes of Kupffer cells coinciding with their functional alterations. Alteration of Kupffer cell phagocytic function is mainly due to the changes of number and cellular activity of Kupffer cells.

Objective: To study the lung tissue TLR4 expression and airway hyperresponsiveness(AHR) in the mice infected by respiratory syncytial virus(RSV).Methods:16 clean,6 weeks old BALB/c mice were divided into two groups equally(RSV group and control).One week after RSV infection,AHR was detected by inhaling the increased concentration of methacholine,TLR4 mRNA expression was measured by RT-PCR methods,and the correlation between AHR and TLR4 expression was also analyzed.Results:An important difference was detected in two groups' airway resistance when the inhaled concentration of methacholine was 3.2g/L(P