Systemic lupus erythematosus is an autoimmune-mediated inflammatory diseases in which immunologic derangement throughout this process.There are a varriety of abnormal immunoregulation,including the disturbance of Help T cell 1,Help T cell 2,Th17 cell and regulatory T cell( Treg cell),disfunction of the B cell subsets and deficiency of the immune tolerance,lead to the disturbance of related cytokines.Recently,it was indicated that the abnormal of cross regulation existencd between Help T cell 1 and Th17 cell,and the disfunction of non-antibody-dependent B cells may play an important role in the pathogenesis of SLE,According to different immune status,appropriate and targeted treatment was given in order to improve the prognosis of the patients with systemic lupus erythematosus.

Alpha-fetoprotein (AFP) was first discovered over 50 years ago, and is currently applied clinically in diagnosis, effects evaluation and relapse judgement of tumors especially for the primary hepatocellular carcinomas.And as an effective tumor marker, AFP test has become one of the essential items in physical examination.However, its clinical application is not limited to primary hepatocellular carcinomas,and its great application value has been proved in many benign diseases and other tumors (non-hepatic carcinomas).

The intestinal mucosa is the biggest lymph organ in human body, which consists of the first line of defensive system with the respiratory mucosa and urinary mucosa. The intestinal mucosa is responsible to defend bacteria, viruses, dietary pathogens, non-steroid anti-inflammatory drug and so on. If the intestinal mucosal immune system is destroyed, the human will suffer many diseases such as infectious diseases,autoimmune diseases. Therefore, it plays an important part in physical health. T helper type 17 (Th17) cells different from Th1 cells and Th2 cells are a distinct lineage of T cells. The discovery of Th17 cells has ruined the constitutional pattern of Th1/Th2. Th17 cells, which are important parts of intestinal mucosal immune system,play critical roles in intestinal autoimmune diseases, tissue inflammation and the infection of various pathogenic bacteria. This paper will review the differentiation of Th17 cell and its function in intestinal mucosal barrier,intestinal autoimmune diseases and intestinal infectious diseases.

Select 106 pregnant women with threatened preterm labor between 28 and 37 weeks of gestation. They have been treated continually by the preventing preterm labor therapy including antibiotics and magnesium sulfate. Cervicovaginal fetal fibronectin (fFN) and C-reactive protein (CRP) in serum were detected before treatment and after 3-day and 7-day treatment respectively. 100 normal pregnant women were included as control group. (1) The fFN and CRP had significant differences between study group and control group (P<0.05). (2) The fFN and CPR were different compared in the treatment period (P<0.05). Fetal fibronectin and CRP can be used can be used in therapeutic effect evaluation of threatened preterm labor.
C-Reactive Protein ; analysis ; Female ; Fibronectins ; blood ; Humans ; Infant, Newborn ; Obstetric Labor, Premature ; diagnosis ; prevention & control ; Pregnancy

Certain specific cancer stem cell subpopulation has been isolated from many kinds of tumors by some specified cell surface maker, including myeloma, lung carcinoma, colon cancer, prostate cancer and pancreatic carcinoma. However, poor individual specificity of cell surface maker molecules and heterograft-related problems provoke more researchers to find more specified cell surface makers and establish humanized mice receptor model in the future. From a clinical perspective, tumor stem cells are considered to be the potential target for curing cancer. Research advances in tumor stem cells can help us to elucidate the close relationship between tumor stem cells and tumorigenesis and provide new ideas and alternative pathways for us to conquer the tumor and avoid tumor recurrence and metastasis.

Objective To understand ureaplasma urealyticum(Uu)and mycoplasma hominis(Mh)infection and drug resistance of mycoplasma from infertility patients in Lanzhou,to direct the clinical use of antibacterial drugs.Methods Uu and Mh from 1 278 cases were cultered and tested as well as their drug resistance were analyzed.Results 42.9%infertility patients showed Uu positive,7.0% showed Mh positive,and 9.0% infertility patients were mixed infection of both Uu and Mh.The sensitive antibacterial drugs were josamycin,doxycycline,minocycline hydrochloride,and clarithromycin,which the sensitive rates of both Uu and Mh were>80%,however,the sensitive rates of Uu and Mh against ciprofloxacin were 11.3% and 16.0%,respectively.Conclusion The mycoplasma infection rate was high in infertility patients,and the problem of drug resistance was serious.The results of drug sensitivity analysis should be recognized as a guide for rational drug use.

The procedure of treating prostate cancer is as the following: After local prostatectomy or radiotherapy or local palliative therapy, androgen-dependent prostate cancer(ADPC) should be given first-line endocrinal therapy. Almost all patients will be developed from ADPC to hormone independent prostate cancer (HIPC) after 14 ～ 30 months, including androgen-independent prostate cancer(AIPC) and hormone-refractory prostate cancer(HRPC). Second-line endocrinal therapy and chemotherapy should be given, respectively. Antibone metastasis therapy is given when bone metastasis occurred. All medical methods should be used rationally and comprehensively to improve the management of prostate cancer.

Bronchial asthma is a chronic inflammatory disorder of the airways,caused by multiple genetic and environmental factors.Thtee key methods including candidate gene study,the positional cloning and genomewide association studies.are used for asthma susceptibility gene identification.There are many candidate genes that haye been identified as asthma susceptibility gene, including ADRB2,IL4R,FLG,NPPA,INPP4A,ADAM33, DPP10,OPN3,0RMDL3,PDE4D,CHBLI etc.Replication of genetic associations and demonstration of a functional mechanism for the associated gene variants are needed to COnfirm an asthmasusceptibility gene, this will help us to understand the aetiology of asthma and explore new drugs to treat asthma.

One hundred fifteen surgical specimens were studied by gram-stain, aerobic and anaerobic cultu- res, as well as gas chromatography, respectively. One hundred seventy six strains, including ninety five aerobic and eighty one anaerobic strains, were isolated. The results suggested that diagnosis of anaerobic bacteria by gas chromatography could be accomplished within 1 h. The specificity of this method was 98.11% and the sensitivity, 90.47%. In addition, the early identification of anaerobic bacteria could be made also. There is higher value for rapid diagnosis of anaerobic infection with gas chromatography.

The mechanism of hypotensive effect of siiybin was studied in anesthetized cats and rats. The results show that the hypotensive action caused by siiybin is not central in origin, and not related to the effect of autonomic nervous system and the release of histamine and prostagiandin, but is mainly due to vasodilation.