Select 106 pregnant women with threatened preterm labor between 28 and 37 weeks of gestation. They have been treated continually by the preventing preterm labor therapy including antibiotics and magnesium sulfate. Cervicovaginal fetal fibronectin (fFN) and C-reactive protein (CRP) in serum were detected before treatment and after 3-day and 7-day treatment respectively. 100 normal pregnant women were included as control group. (1) The fFN and CRP had significant differences between study group and control group (P<0.05). (2) The fFN and CPR were different compared in the treatment period (P<0.05). Fetal fibronectin and CRP can be used can be used in therapeutic effect evaluation of threatened preterm labor.
C-Reactive Protein ; analysis ; Female ; Fibronectins ; blood ; Humans ; Infant, Newborn ; Obstetric Labor, Premature ; diagnosis ; prevention & control ; Pregnancy

Alpha-fetoprotein (AFP) was first discovered over 50 years ago, and is currently applied clinically in diagnosis, effects evaluation and relapse judgement of tumors especially for the primary hepatocellular carcinomas.And as an effective tumor marker, AFP test has become one of the essential items in physical examination.However, its clinical application is not limited to primary hepatocellular carcinomas,and its great application value has been proved in many benign diseases and other tumors (non-hepatic carcinomas).

Systemic lupus erythematosus is an autoimmune-mediated inflammatory diseases in which immunologic derangement throughout this process.There are a varriety of abnormal immunoregulation,including the disturbance of Help T cell 1,Help T cell 2,Th17 cell and regulatory T cell( Treg cell),disfunction of the B cell subsets and deficiency of the immune tolerance,lead to the disturbance of related cytokines.Recently,it was indicated that the abnormal of cross regulation existencd between Help T cell 1 and Th17 cell,and the disfunction of non-antibody-dependent B cells may play an important role in the pathogenesis of SLE,According to different immune status,appropriate and targeted treatment was given in order to improve the prognosis of the patients with systemic lupus erythematosus.

Bronchial asthma is a chronic inflammatory disorder of the airways,caused by multiple genetic and environmental factors.Thtee key methods including candidate gene study,the positional cloning and genomewide association studies.are used for asthma susceptibility gene identification.There are many candidate genes that haye been identified as asthma susceptibility gene, including ADRB2,IL4R,FLG,NPPA,INPP4A,ADAM33, DPP10,OPN3,0RMDL3,PDE4D,CHBLI etc.Replication of genetic associations and demonstration of a functional mechanism for the associated gene variants are needed to COnfirm an asthmasusceptibility gene, this will help us to understand the aetiology of asthma and explore new drugs to treat asthma.

The intestinal mucosa is the biggest lymph organ in human body, which consists of the first line of defensive system with the respiratory mucosa and urinary mucosa. The intestinal mucosa is responsible to defend bacteria, viruses, dietary pathogens, non-steroid anti-inflammatory drug and so on. If the intestinal mucosal immune system is destroyed, the human will suffer many diseases such as infectious diseases,autoimmune diseases. Therefore, it plays an important part in physical health. T helper type 17 (Th17) cells different from Th1 cells and Th2 cells are a distinct lineage of T cells. The discovery of Th17 cells has ruined the constitutional pattern of Th1/Th2. Th17 cells, which are important parts of intestinal mucosal immune system,play critical roles in intestinal autoimmune diseases, tissue inflammation and the infection of various pathogenic bacteria. This paper will review the differentiation of Th17 cell and its function in intestinal mucosal barrier,intestinal autoimmune diseases and intestinal infectious diseases.

Objective To understand ureaplasma urealyticum(Uu)and mycoplasma hominis(Mh)infection and drug resistance of mycoplasma from infertility patients in Lanzhou,to direct the clinical use of antibacterial drugs.Methods Uu and Mh from 1 278 cases were cultered and tested as well as their drug resistance were analyzed.Results 42.9%infertility patients showed Uu positive,7.0% showed Mh positive,and 9.0% infertility patients were mixed infection of both Uu and Mh.The sensitive antibacterial drugs were josamycin,doxycycline,minocycline hydrochloride,and clarithromycin,which the sensitive rates of both Uu and Mh were>80%,however,the sensitive rates of Uu and Mh against ciprofloxacin were 11.3% and 16.0%,respectively.Conclusion The mycoplasma infection rate was high in infertility patients,and the problem of drug resistance was serious.The results of drug sensitivity analysis should be recognized as a guide for rational drug use.

Objective To explore the relationship between serum hs -CRP,IL -17 levels and senium type 2 diabetic macrovascular complications and its clinical significance.Methods The serum levels of hs -CRP and IL-17 were measured with immunoturbidimetry and ELISA respectively in 80 cases of type 2 diabetic patients with macrovascular complications,80 cases of the absence of any major vascular complications in patients with type 2 diabetes and 80 healthy subjects as the control.Results The serum hs -CRP and IL -17 levels of senium type 2 diabetic Patients with macrovascular complications were significantly higher than those of patients without macrovascular complication and healthy control group(t =19.18,23.14,all P <0.01);And serum hs -CRP and IL -17 levels of seniumtype 2 diabetic patients without macrovascular complications were also significantly higher than those of the healthy control group (t =23.64,19.97,all P <0.05 );While serum hs -CRP and IL -17 levels in different subgroup of type 2 diabetic patients with macrovascular complications were no significantly statistical significance(F =1.08,1.49,all P >0.05);In patients of type 2 diabetic Patients with macrovascular complications,hs -CRP was positively correlated with serum IL -17(r =0.712,P <0.05).Conclusion Hs -CRP and IL -17might be involved in the process of inflammatory response to diabetic macroangiopathy,and may have important role in the pathogenesis of senium type 2 diabetic patients with macrovascular complications.Detemination of hs -CRP and IL -17 levels in type 2 diabetic patients may be useful for early detecting diabetic macrovascular complications and serve as the index in monitoring the state of diabetic macrovascular complications.

Objective To compare the efficacy of continuous positive airway pressure (CPAP) with that of surgical treatment for obstructive sleep apnea-hypopnea syndrome (OSAHS) in elderly patients. Methods Seventy patients with OSAHS were divided into a study group and a control group according to different treatment methods. The study group received CPAP, while the control group underwent surgical treatment. One month after treatment, apnea-hypopnea index (AHI), lowest oxygen saturation (LSaO2), ESS scale value, coagulation factors, and platelet count were measured in both groups. Results AHI and LSaO2 were lower and ESS scale value was higher in the study group than in the control group, but with no significant differences (P>0.05). After treatment, all the indexes of coagulation factors were increased in the control group, but only plasma clotting factorⅡactivity had a significant statistical difference (P<0.05); (FⅡ: C) and (FⅧ: C) were significantly lower in the study group than in the control group (P<0.05); platelet count significantly increased in the control group (P<0.05), but markedly declined in the study group (P<0.05). Conclusions Both CPAP and surgical treatment have a better effiacy for obstructive sleep apnea-hypopnea syndrome. CPAP can more effectively improve coagulation function and lower the risks of complications.

Objective:To observe the clinical curative effect of narrow-band UVB-LED (308nm) combined with tacrolimus, narrow-band UVA-LED (365nm) combined with 8-Methoxypsoralen irradiation in the treatment of vitiligo.Methods: Sixty-four cases of vitiligo patients were chosen and randomly divided into control group and observation group, each group with 32 cases. The control group received 308nm narrow-band UVB-LED irradiation combined with tacrolimus,the observation group received 365nm narrow-band UVA-LED irradiation combined with 8-Methoxypsoralen, the time of appreance of the first pigment island in patients were compared between the two groups,the clinical curative effect of both groups were observed when treated with 10 times and 20 times.Results: The average irradiation times when first pigment island appreance in the observation group and the control group were 5.59 and 6.24 respectively, the difference was not statistically significant (t=1.772,P>0.05). The efficiency rate of the control group was 37.50% after 20 times treatment, and in the observation group was 40.63%, the difference was not statistically significant (x2=0.000,P>0.05).Conclusion: 308nm narrow band UVB-LED combined with tacrolimus and 365nm narrow-band UVA- LED combined with 8- Methoxypsoralen irradiation in the treatment of vitiligo have significant treatment effects, how to improve the treatment effect still need further study.

OBJECTIVE:To explore the characteristics and regularity of ADR induced by gynecological Chinese patent medi-cine,and to provide reference for rational use of gynecological Chinese patent medicine. METHODS:ADR reports were collected from gynecological ADR reporting information system of our hospital during 2008-2105;all ADR cases of Chinese patent medicine were collected and analyzed. RESULTS:No severe ADR was found among 41 cases of Chinese patent medicine-induced ADR,24 cases of new and common ADR(58.54%),17 cases of common ADR(41.46%);the incidence of ADR was in high level 1-3 d after medicating,being 97.6%. Main routes of administration were oral administration(19 cases,46.3%)and vaginal administra-tion(15 cases,36.6%)in ADR cases. Clinical manifestations were gastrointestinal reaction(29.97%),systemic reaction(19.15%) and mild injury of reproductive system(17.02%),etc. CONCLUSIONS:Chinese patent medicine is relatively safety in gynecologi-cal department. However,caution should be exercised in special cases and different medication.