This is a progress report on myelodysplastic syndromes (MDS) treatment with Chinese medicine containing arsenic in clinic and DNA methylation.Thousands of patients with MDS have been treated by Chinese medicine containing arsenic and 80 ％ total effective rate was got.A few of patients had discontinued the treatment more than one year and all of their blood indicators were normal level.Abnormal methylation in MDS appeared not only obvious hypermethylation but also hypomethylation of some genes.Our research revealed that the mechanism of Chinese medicine containing arsenic on MDS was a two-way regulation of DNA with main mechanism of demethylating and part mechanism of methylating.

The myelodysplastic syndromes (MDS) are a group of clonal heterogeneous disorders of hematopoietic/progenitor.There are differences between Chinese and Western on cytogenetic typing of MDS.The arsenic-containing Chinese herbal formula Qinghuang powder is exact effective in the treatment of MDS.The clinical effect mechanism research indicated that treatment with arsenic-containing Chinese herbal formula had no effect on karyotype status,but resulted in a significant genome wide demethylation.The effective arsenic-concentration in blood is (19.39±10.36) μg/L,which is obviously lower than that in treating APL.

Antineoplastic Agents ; therapeutic use ; Arsenicals ; therapeutic use ; Humans ; Myelodysplastic Syndromes ; drug therapy ; Oxides ; therapeutic use

Bone Marrow ; immunology ; pathology ; Drugs, Chinese Herbal ; therapeutic use ; Hematopoietic System ; immunology ; pathology ; Humans ; Immunosuppression ; Phytotherapy

Myelodysplastic syndromes (MDS) are heterogeneous clonal stem cell disorders characterised not only by peripheral cytopenia and bone marrow hyperplasia but also by karyotype. The course of disease, clinical outcome and response to treatment. Cytogenetic categories is a pattern typing the intrinsical features of MDS. It is suggested here that investigating biological characters and group treatment in MDS based on cytogenetic categories may enhance the therapeutic effect and bring benefit to MDS patients.

Chronic Disease ; Humans ; Immunologic Deficiency Syndromes ; complications ; immunology ; therapy ; Medicine, Chinese Traditional ; methods ; Thrombocytopenia ; complications ; immunology ; therapy

Hematology ; Humans ; Integrative Medicine

Anemia, Aplastic ; drug therapy ; Animals ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Leukemia, Myeloid, Acute ; drug therapy ; Medicine, Chinese Traditional ; Phytotherapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; drug therapy ; Purpura, Thrombocytopenic, Idiopathic ; drug therapy

Hematologic Diseases ; Medicine, Chinese Traditional ; standards ; Terminology as Topic

Aged ; Cyclosporine ; therapeutic use ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Myelodysplastic Syndromes ; drug therapy ; Phytotherapy