1.Chemical composition and in vitro antitrypanosomal activity of fractions of essential oil from Cymbopogon nardus L.
Muhd Haffiz, J. ; Norhayati, I. ; Getha, K ; Nor Azah, M.A. ; Mohd Ilham, A. ; Lili Sahira, H. ; Roshan Jahn, M.S. ; Muhd Syamil, A.
Tropical Biomedicine 2013;30(1):9-14
Essential oil from Cymbopogon nardus was evaluated for activity against
Trypanosoma brucei brucei BS221 (IC50 = 0.31 ± 0.03 μg/mL) and cytotoxic effect on normal
kidney (Vero) cells (IC50 = >100 μg/mL). The crude essential oil was subjected to various
chromatography techniques afforded active sub fractions with antitrypanosomal activity; F4
(IC50 = 0.61 ± 0.06 μg/mL), F6 (IC50= 0.73 ± 0.33 μg/mL), F7 (IC50 = 1.15 ± 0 μg/mL) and F8
(IC50 = 1.11 ± 0.01 μg/mL). These active fractions did not exhibit any toxic effects against
Vero cell lines and the chemical profiles investigation indicated presence of α-and γ-eudesmol,
elemol, α-cadinol and eugenol by GC/MS analysis.
Result Analysis
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