Objective To study the change of regular semen parameters in infertile patients with simple low-pH semen before and after symptomatic treatment.Methods A total of 100 male infertility patients were recruited in the study,and were divided into two groups according to the pH range:patients group Ⅰ(n=40)and patients group Ⅱ(n=60);The two patients groups were tea-ted for low pH semen.When the first and second course of treatment were finished,semen pH values and conventional semen pa-rameters were tested and compared with those before treatment and control group.Results When the first course of treatment were finished,semen pH value of 75%(30/40)patients in group Ⅰ reached normal range,compared with the control group,the semen parameters were statistically different(P <0.05);Semen pH value of 85%(51/60)patients in group Ⅱ reached normal range,com-pared with the control group,the semen parameters were all statistically different(P <0.05).When the second course of treatment were finished:semen pH value of 80%(32/40)patients in group Ⅰ reached normal range,compared with control group,the semen parameters and pH values were not statistically different(P >0.05);Semen pH value of 90%(54/60)patients in group Ⅱ reached normal range,compared with the control group,the semen parameters and pH values were not statistically different(P >0.05 ). Conclusion The semen quality improved after the symptomatic treatment for low semen pH value and its an effective therapeutic approach for infertile patients with simple low-pH semen.