Objective To analyze the clinical,radiological and pathdogical characteristics of idiopathic lymphoid interstitial pneumonia (idiopathic LIP) and to discuss its diagnosis,treatment and prognosis.Methods Respiratory physicians,pathologists and radiologists together retrospectively analyzed the clinical,chest roentgenogram,computerized tomography,pathologicM,diagnostic and therapeutic data of 3 patients with idiopathic LIP confirmed by lung biopsy.and reviewed the relevant literatures.Results The major symptoms of the 3 cases of idiopathic LIP were prgressive dyspnea and dry cough.Higher levels of γ-globulins in serum were found in all the cases.The characteristic radiographic manifestations were bilateral diffuse nodules and cysts.The pathologic feature was diffuse interstitial inflammation with polyclonal lymphocytes infiltration,especially with plasma lymphocytes.Corticosteroids and cytotoxic agents were used and good response to therapy was observed in the cases.Conclusions Idiopathic LIP has some characteristics on the clinical,radiological and pathological features,but the best diagnostic method depends on a clinical-radiological-pathological approach.The disease usually shows good response to combinative therapy of corticosteroids and cytotoxic agents.

To study the histogenesis, biological behaviour, classification of pituitary adenoma and the relationship between the symptoms of hormonal hypersecretion and the hormone test in pituitary adenoma. MethodsOne hundred and eighty cases of pituitary adenoma were investigated by clinicopatholgic analysis, and GH, PRL, ACTH, TSH, FSH, LH were examined in 110 cases by ABC immunocytochemical methods. ResultsForty percent of the patients were found to have the identical results between the clinical symptoms and hormonal test. Female patients were more than male ones, and the difference was satistically significant. The results showed that PRL and GH adenoma were often found in the cases by immunocytochemical method,and mixed GH-PRL adenoma were often found in the cases with multihormono-adenoma. ConclusionThe classification is practical and easy to operate, which combines the immunohistochemical examination of pituipary adenoma with the morphology and function.

AIM:To observe the effect of arsenic trioxide (ATO) on bleomycin-induced pulmonary fibrosis in rats. METHODS:Pulmonary fibrosis was induced in Sprague-Dawley (SD) rats by intratracheal instillation of bleomycin (BLM). The rats in ATO treatment group,steroid treatment group and model group were intraperitoneally injected with ATO,dexamethasone or normal saline (NS),respectively,while the control rats received NS both intratracheally and intraperitoneally. The effects of ATO were evaluated by analyzing the median survival time,hydroxyproline level in the lung,semiquantitative grading of alveolitis and pulmonary fibrosis,and quantitative analysis of the collagen in lung tissue (Masson's trichrome staining). Apoptosis index (AI) of the lung was detected by using the terminal transferase dUTP-digoxygenin nick endlabeling (TUNEL) method. The results of immunohistochemical staining for some cytokines were quantitatively analyzed. RESULTS:ATO (1) prolonged the median survival time of rats with BLM-induced pulmonary fibrosis at some extent; (2) attenuated the alveolitis and pulmonary fibrosis,reduced hydroxyproline level and collagen deposition in the lung tissue; (3) increased the AI of lung tissue at a certain phase; and decreased the levels of transforming growth factor-?1(TGF-?1) and tissue inhibitor of metalloproteinase-1 (TIMP-1),increased the content of in-terferon-? (IFN-?),but did not influence the concentration of matrix metalloproteinase-9 (MMP-9) significantly. CONCLUSION:ATO might attenuate BLM-induced pulmonary fibrosis in rats via increasing the AI in the lung tissue.

Objective:To explore the application effect of patient mutual assistance model guided by the hierarchy of needs theory in patients with acute myocardial infarction.Methods:Using the convenient sampling method, 40 patients with acute myocardial infarction in the Fourth People's Hospital of Haikou from September 2018 to October 2019 were selected as the control group and 40 patients with acute myocardial infarction from November 2019 to January 2021 were selected as the intervention group. The control group implemented the conventional nursing model, and the intervention group implemented the patient mutual assistance model guided by the hierarchy of needs theory on this basis. Perceived Stress Scale (PSS) , SDS and Herth Hope Scale (HHI) were used to evaluate the effect of intervention.Results:After the intervention, the total scores of PSS of patients in the two groups were lower than those before the intervention, and the difference was statistically significant ( P<0.01) . And the total PSS score of the intervention group was lower than that of the control group, and the difference was statistically significant ( P<0.01) . After the intervention, the total SDS score of patients of the two groups was lower than that before the intervention, and the difference was statistically significant ( P<0.01) . And the total SDS score of the intervention group was lower than that of the control group, and the difference was statistically significant ( P<0.01) . After intervention, the scores of HHI dimensions and total scores in two groups were higher than before intervention, and the differences were statistically significant ( P<0.01) . The scores of HHI dimensions and the total score of the intervention group were higher than those in the control group, and the differences were statistically significant ( P<0.01) . Conclusions:The patient mutual assistance model guided by the hierarchy of needs theory can effectively reduce the self-perceived pressure of patients with acute myocardial infarction after PCI, improve their depression and increase the level of hope.