Objective To evaluate the laparoscopic hysterectomy surgery continuous infusion of low-dose sufentanil combined with propofol and remifentanil anesthesia postoperative hyperalgesia influence.Methods Patients were collected from June 2013 to June 2015 in our hospital undergoing laparoscopic hysterectomy 60 cases.According to the principles of randomized, divided into sufentanil group (SF group) and 30 cases of normal saline group (NS group) 30 cases.Two intraoperative remifentanil 0.1-0.2 μg/(kg? min) and propofol 4-8 mg/(kg? h) to maintain anesthesia.After the operation began, SF group and NS group were sufentanil and saline.Record calls eyes, recovery of spontaneous breathing, extubation time;after waking 5 min, 30 min, 12 h, 24 h, 48 h pain (visual analogue scales, VAS) score; before induction (T0), after induction (T1), after intubation (T2), surgery (T3), extubation (T4), after extubation 10 min (T5) heart rate (HR) and mean arterial pressure (MAP); excessive sedation, respiratory depression, intraoperative awareness, restless when awake, intraoperative after nausea/vomiting, tramadol and so on.Results SF group and NS group recovery of spontaneous breathing, eye opening and extubation call time was not statistically significant;after SF group wake 5 min, 30 min and 4 h VAS scores lower than the NS group (P <0.05); in T4, T5 point comparison, SF group MAP and HR lower than the NS group (P <0.05); SF group restless when awake, pain (VAS score≥3), postoperative use of tramadol was lower than NS group (P<0.05).Conclusion Intraoperative continuous infusion of low-dose sufentanil improve laparoscopic hysterectomy in patients under anesthesia using propofol combined with remifentanil hyperalgesia, with good prospects for clinical application of anesthesia.

Objective To investigate the influence of opioids drug doses difference on sedation ,analgesia effects and risk of adverse effects in patients undergoing elective orthopedics operation .Methods From January 2015 to January 2017, 120 patients undergoing elective orthopedics operation in Zhoushan Hospital were chosen and randomly divided into 3 groups according to the digital table ,including low dose group (40 patients) with sufentanil of 0.1μg/kg,moderate dose group(40 patients) with sufentanil of 0.15μg/kg,and high dose group(40 patients) with sufentanil of 0.2μg/kg.The VAS score and Ramsay score after operation ,analgesic drugs addition rate ,addition dose and incidence of adverse effects among 3 groups were compared.Results The VAS scores of the moderate dose group and high dose group at 1h,6h and 12h after operation were significantly lower than those of the low dose group (t＝3.5,3.72,4.19,4.33,3.10,2.43,all P＜0.05).There were no statistically significant differences in Ramsay score after operation among 3 groups(F＝1.02,0.47,0.75,0.94,all P＞0.05).The analgesic drugs addition rate and addition dose of the low dose group were 22.50%,(78.28 ±9.54)mg,respectively,which of the moderate dose group were 7.50%,(63.50 ±6.02) mg,respectively,which of the high dose group were 5.00%,(62.74 ±5.88) mg, respectively.The analgesic drugs addition rate and addition dose of moderate dose group and high dose group were significantly lower than those of the low dose group (χ2/F＝7.48,8.33,3.26,3.41,all P＜0.05).The incidence rate of adverse effects in the high dose group was significantly higher than those in the low dose group and moderate dose group(χ2＝8.12,12.96,7.95,12.02,all P ＜0.05).Conclusion Compared with sufentanil of 0.1μg/kg and 0.2μg/kg,the sufentanil of 0.15 μg/kg on patients undergoing elective orthopedics operation has better analgesia effect.