Objective To observe the mild chronic obstructive pulmonary disease (COPD) patients′oropharyngeal flora distri‐bution state ,discuss the illness development and prevention measure of COPD patients with oropharyngeal flora disorder .Methods 124 cases of mild COPD patients from the medical center were enrolled in the study to do bacterial culture of swabs ,and 100 cases of healthy subjects were recruited at the same time to do bacterial culture of swabs as control group .The oropharyngeal bacteria distribution state was observed .Results The number of species and detection rates of main pathogenic bacteria and conditional pathogenic bacteria in COPD patients was higher than healthy subjects .In mild COPD patients ,the patients with abnormal oropha‐ryngeal bacteria isolates≥3 ,accounted for 29 .0% (36/124) which was significantly higher than that in control group(8 .0% ,8/100) and the difference was statistically significant(P< 0 .05) .Conclusion Because of immune factors and bad living habits such as smoking ,which could lead to the disorder of body′s normal flora ,infection and make the illness developed .Monitoring of oropharyn‐geal flora distribution state ,and taking active measures to prevent and control it had clinical significance in the prevention of infec‐tion and the development of mild COPD .

Objective To compare the treatment effects of different dosage of tamsulosin for patients with type Ⅲ prostatitis.Methods 150 patients with type Ⅲ prostatitis were selected as study objects.They were divided into control group and research group according to the digital table,each group in 75cases.The research group was treated with tamsulosin 2 tablets (0.4mg),1 time a day.The control group was treated with tamsulosin 1 tablet (0.2mg) + starch tablet 1 tablet,1 time a day.After treatment for 12 weeks,the clinical effects,NIH-CPSI score,white blood cell count and pH value,and adverse reaction between the two groups were compared.Results The total effective rate of the research group was higher than that of the control group(93.33％ vs.81.33％),the difference was statistically significant (x2 =4.881,P ＜ 0.05).After treatment,the pain,voiding symptoms,quality of life and NIH-CPSI scores in the research group were (5.13 ± 4.02) points,(2.52 ± 1.07) points,(3.64 ± 3.25) points,(9.19 ± 0.63) points,respectively,which were lower than those in the control group [(8.25 ± 3.54) points,(3.28 ± 1.87) points,(5.57 ± 3.62) points,(16.47 ± 0.38) points],the differences were statistically significant (t =5.044,3.055,3.436,85.693,all P ＜0.05).The white blood cell and pH value of the research group were (12.65 ± 5.88) x 109/L,(6.29 ±0.20),respectively,which were lower than those in the control group [(16.58 ±6.24) x 109/L,(6.73 ± 0.16)],the differences were statistically significant (t =3.970,14.878,all P ＜ 0.05).The single occurrence rate and total occurrence rate between the two groups had no statistically significant differences (x2 =0.340,0.207,0.000,0.000,0.362,all P ＞ 0.05).Conclusion The effect of tamsulosin in dose of 0.4 mg is better than 0.2 mg,and had no significant impact on safety.

Objective To evaluate the efficiency of inhaling penehyelidine hydyoehloride(PHC)in reducing pulmonary arterial pressure and improving lung funetion in patients with acute exaeerbation of ehronie obstruetive pulmonary disease(AECOPD).Methods Sixty patients with AECOPD were randomly divided into the control group(30 patients) and the treatment group(30 patients).The patients in treatment group inhaled PHC,and patients in control group inhaled diprophylline.The pulmonary arterial pressure was measured before and after inhalation.The peak expiratory flow(PEF) and forced expiratory volume in one second(FEV1)was measured at different time points before and after inhalation. Arterial blood gas and,symptoms were also observed.Results The pulmonary arterial pressure in treatment group was reduced by 20% and reduced by 5% in the control group.FEV1 and PEF were improved after inhalation,the average increase of FEV1 was 350 ml(P＜0.01),and PEF was improved by 37 L/min(P＜0.05).Arterial blood gas analysis was improved,and PaO_2 increased by 18 mmHg(P＜0.01).The respiratory rate and the symptoms of cough and sputum were also improved.Conclusion PHC improved the lung function of patients with AECOPD by reducing the pulmonary arterial pressure.

Objective To explore a method of modified technique of sagittal split ramus osteotomy (SSRO) and to study the possibly more appropriate and effective methods for correction of mandibular de-formity. Methods 195 patients suffering from mandibular anomaly or accompanied by other deformities have been operated on by the modified or classical technique of SSRO. Results In the group of 105 cases treated by modified SSRO and the group of 90 classical SSRO, all the patients acheived excellent results. There was no statistic significance between the two groups. No complications occured, such as postopera-tive relapse, significant bleeding, postoperative infection, and others. Conclusion Since modified tech-nique of SSRO has more advantages than conventional classical technique, such as more area of bony con-tact, shorter-time operation, easier process: it is the preferred method for the correction of mandibular deformity. Accompanied by regularity and in time pre- and post-operational orthodontic therapy, it will be more widely used in the future.

Objective To correct bimaxillary protrusion by using b oth orthognathic operation and orthodontic treatment. Methods 46 bimaxillary protrusion patients, 7 male, 39 female, aged from 19 to 31 years (mean 24.2 years), were surgically corrected since 1996. Of them 31 cases underwent preoperative orthodontic treatment. Cephalometric analysis and model s urgery were performed in all patients and 4 kinds of operation methods were used to correct the deformity. All osteotomy segments were fixed with rigid internal fixation. 39 cases underwent postoperative orthodontic treatment. Re sults 34 cases had been followed-up for ranged from 12 to 72 months (mean 27.7months). All osteotomy segments healed well. There were no severe com plications and evident relapse. The maxillary osteotomy segments were moved back for average (6.3?0.9) mm and mandibular osteotomy segments for average (5.2?1 .2) mm. Both occluding relation and facial contour were satisfied. Co nclusion Bimaxillary protrusion can be satisfyingly corrected by usi ng both of orthognathic operation and orthodontic treatment.

OBJECTIVE: To construct informational pharmaceutical care system(IPCS) for clinical pharmacists and to improve the level of pharmaceutical care.METHODS: By means of the latest ideas on pharmaceutical care and the support of local area network technology of Hospital Information System,the construction and running of IPCS for clinical pharmacists were illustrated using clinical cases.RESULTS: Based on the establishment of pharmaceutical record database,we could realize the integration of IPCS which included the automatic monitoring of important drugs and bacteria,clinical pharmacist consultation,information collection,information publication,information inquiry,medication counseling,establishment of specialized pharmaceutical staff and online further education,etc.CONCLUSION: The pharmaceutical care based on information platform is a good practice model for clinical pharmacy.It is the only way for clinical pharmacists to carry out further development of pharmaceutical care.

Objective To study the method of selecting appropriate exposure parameter of AOP mode and reducing the radiation dose effective with the control of image quality .Methods The unique mammary phantom was mammography in three different AOP mode(DOSE mode ,STD mode and CNT mode) and compared the radiation dose .150 sample was selected randomly .50 sample each mode ,and recorded the radiation dose .All image reach the diagnostic standard .The mean dose of the each mode were computed and compared with others .Results whatever the phantom mammography and the sample mammography ,the mean dose in DOSE mode was lowest ,higher in STD mode ,and highest in CNT mode .The number of fiber cords ,mass and calcification fit the standard of quality control .The image of sample aslo fit the diagnostic standard .Conclusion In daily work ,we can lower the dose choosing appropriate mode according to the thickness and density of mammary .DOSE mode prior ,STD mode advocate limit to CNT mode .

Purpose Ovarian dysgerminoma has no specific symptoms or physical signs, which is thus prone to misdiagnosis before treatment. This paper aims to investigate CT and MRI clinical features of ovarian dysgerminoma, so as to provide an accurate basis for its clinical treatment and also improve patients'' life, quality.Materials and MethodsThe CT and MRI data of 13 patients with ovarian dysgerminoma proved by pathology were retrospectively analyzed. Three patients underwent plain and enhanced CT scan, 6 took plain and enhanced MRI scan on T1WI and T2WI with different angles of views, and 4 other patients were performed both CT and MRI scan.Results①Twelve patients had single lesions, and 1 was bilateral multiple ones. The diameter of the lesions ranged from 5.5 cm to 16.5 cm, with mean of (9.5±3.8) cm; in terms of pathological type, 11 belonged to single type and 2 were mixed.②The CT results showed that 6 were solid mass and 1 was cystic. On enhanced CT scan, 6 cases showed heterogeneous light-to-moderate enhancement, 4 had tumors with significantly enhanced blood vessels, and 1 showed heterogeneous significant enhancement at arterial phase; all cases presented continuous enhancement at venous phase.③The MRI manifestations demonstrated 8 were with solid mass, which displayed iso- or slightly hypointense signal on T1WI, and iso- or slightly hyperintense signal on T2WI. The enhanced scan showed that 5 cases had heterogeneous mild enhancement, 3 had moderate enhancement, and 4 were seen with tortuous tumor vessels at arterial phase; all displayed continuous enhancement at venous phase. In the one case of cystic mass, solid component had moderate enhancement at arterial phase and continuous enhancement at venous phase. In another case of multilocular cystic mass, the tumor separate and cyst were significantly enhanced at arterial phase, and were continuous enhanced with hyperintense at venous phase.Conclusion Ovarian dysgerminoma tumors present features such as large lesions with clear boundaries. Tumors of single type are likely to be solid mass with central necrosis; the plain CT scan shows isodensity; the plain MRI scan mainly shows isodensity on T1WI, and iso- or slight hyperintensity on T2WI; the enhanced scan presents slight to moderate enhancement. Tumors of mixed type demonstrate cystic mass; the solid and separate parts are significantly enhanced. The comprehensive analysis of imaging features of ovarian neoplasms could help to make a correct diagnosis before surgery.

OBJECTIVE: To explore an effective approach for clinical pharmacists to provide pharmaceutical care to outpatients.METHODS: Based on our personal experience and the mode of pharmaceutical consultation service in our hospital as well as the case study,the setting up and operational model of drug consultation service for outpatients were introduced.RESULTS & CONCLUSIONS: If requirements on personnel and hardware & software satisfied,setting drug consultation service for outpatients that operated in 5 steps including probing into patient's basic condition and analyzing patient's medication condition etc can greatly enhance patients' medication compliance.

【Objective】 To investigate the matrix effect on the determination of potency in Recombinant Human Coagulation Factor Ⅷ for Injection (rFⅧ). 【Methods】 Two different detection matrices were used to establish two methods for detecting the potency in Recombinant Human Coagulation Factor Ⅷ for Injection. And the matrix effect on the determination of potency was determined, including specificity, linearity, repeatability, accuracy and intermediate precision. 【Results】 As to the specificity, the recoveries of the two substrates at high vs low concentration level were 112% and 110% vs 104% and 109%, respectively. As to the linearity, in the range of (0.125-1.000) IU/mL, the correlation coefficient between concentration and coagulation time of standard/ sample was higher than 0.99. As to the accuracy/repeatability, the recoveries of two matrices was 104% and 102%, and RSD was 2.4% and 1.9%. As to the intermediate precision, personnel factor of two matrices was 0.72 and 0.23, date factor was 0.79 and 0.85, and RSD(for 12 times) was 4.2% and 3.0%. Comparison of two matrices was as follows: Deviation in test results of 6 batches of rFⅧ was all lower than 5%. There was no significant difference between two matrices. 【Conclusion】 The two matrices for potency detection show good performance including specificity, linearity, repeatability, accuracy, and intermediate precision. They are suitable for the determination of potency in rFⅧ products.