[Objective] To sum up the clinical experience of famous veteran doctor LI Rongzhen in treating the fundus oculi disease. [Methods] By learning from Professor LI Rongzhen, recording the relevant cases and analyzing the typical cases, to summarize the academic idea and the clinical experience according to the viscera syndrome differentiation and treatment characteristics, as well as list two proved cases. [Results] Professor LI Rongzhen holds that this disease is closely related with the viscera, origins from heart, involving liver, lung and kidney. In the clinical treatment, Professor LI is good at using the classical prescriptions and the therapy with syndrome differentiation with the permit addition and subtraction, according to the pattern of the fundus oculi disease, which has received the remarkable effect: patients with the deficiency of both heart and spleen of sudden blind, using the principle of nourishing qi to stop bleeding with Guipi Decoction, patients with hyper-action of liver yang, using Zhengan Xifeng Decoction to nourish yin for suppressing hyperactive yang, patients with qi stagnation and blood stasis are treated by Xuefu Zhuyu Decoction to remove stasis and stopp blood;patients with deficiency of kidney-yin of vitreous opacity, using the treatment of tonifying kidney for improving eyesight, with Six Ingredient Rehmannia Pill to nourish the liver and kidney, syndrome with the disharmony of liver and spleen, using Xiaoyao Powder to replenish vital energy ,deficiency of qi and blood, applying Bazhen Decoction to invigorate qi and blood. All of the cases verify her clinical experience. [Conclusion] While treating the fundus oculi disease, Professor LI pays attention to the relation between the eyes and the viscera, using the therapy with syndrome differentiation, with the flexible application of the ancient prescriptions and the traditional Chinese medicine, her experience in treating the fundus oculi disease is well worth learning and using.

This study was aimed to explore the function of c-Jun N-terminal kinase (JNK) signaling pathway in the induction of brain ischemic tolerance, and observe the function of Shu-Xue Tong-Mai (SXTM) capsule pretreatment. Ischemic preconditioning was performed for 3 min on rats to induce cerebral ischemic tolerance. Rat model of cere-bral ischemia reperfusion (the ischemia pretreatment group, I/R group) was established 24 h later. Western blot was used to detect the protein expression of JNK and phosphorylation of c-Jun N-terminal kinase (P-JNK), comparing to the expression with the sham operation group, I/R group and SXTM capsule group. Tunel method was applied to de-tect the apoptosis of neurons. Relationship between expression of JNK, P-JNK and apoptosis of neurons was also studied. The results showed that compared with the model group, expressions of P-JNK in ischemia preconditioning group and SXTM group were declined significantly (P < 0.05); and the apoptosis of neurons quantity was also de-clined (P< 0.05). It was concluded that ischemia preconditioning can decrease the apoptosis of neurons in cerebral ischemia reperfusion, and improve neurologic function. Its mechanism related to the inhibition of JNK signaling path-way. SXTM capsule pretreatment can protect the cerebral by inhibiting the JNK signaling pathway.