Objective To assess the diagnostic value of NMP22 and BTA stat in the detection of bladder cancer. Methods 82 symptomatic patients suspicious of bladder cancer were asked to have urine NMP22,BTA stat,and cytological examination before cystoscopy. Results 32 patients were pathologicaly diagnosed as transitional cell carcinoma,and 50 cases were other benign urological conditions.The sensitivity of NMP22 (87.5%) was significantly better than BTA stat (65.6%) and urinary cytology ( 21.9 %), P