Seven cases of unstable Type 1 diabetic patients were treated with IIT (intensive insulin therapy) -multi-injection insulin regimen. The short-acting insulin (Actrapid HM) administered by insulin-pen injector (NOVO-Pen 1) before meals as meal-related incremental insulin. The long-acting insulin (Ultratard HM) injected at 10 p.m. as basal insulin. After run-in period of 4 weeks then the IIT-period ran for 12 weeks. The results showed that the mean fasting/post-prandial glucose concentration was normalized from 10.6?2.5/16.2?3.9 mmol/L to6.5?0.9/7.0?2.2mmol/L. The mean HbA, fell from 10.2% to 8.2% (normal 6-8%) during the three months period. It can be concluded that the IIT-multi-injecdon insulin regimen improves metabolic control. The NOVO-Pen seems to be better than the traditional syringe as besides its painless injection, it is easy to use and carry; thus makes the multiple injection regimen more attractive.

Sodium orthovanadate is one of vanadate salts. When administered orally to STZ-induced diabetic rats, sodium orthovanadate may stimulate glucose uptake and. metabolism and made them normoglycemic. However, the blood glucose levels of normal rats treated with sodium orthovanadate did not change despite their plasma insulin levels decreased. The insulin-like effect of sodium orthovanadate on carbohydrate metabclism was not due to direct stimulation of insulin secretion, because the plasma insulin concentration of vanadate-treated STZ-rats remained lower and insulin secretion of isolated pancreas perfused with solution containing sodium orthovanadate was smilar to that of controls.