Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

Architecture ; Humans ; Occupational Diseases ; prevention & control ; Occupational Health

Humans ; Periodontal Diseases ; complications ; microbiology ; Periodontium ; microbiology ; Systemic Inflammatory Response Syndrome ; microbiology

Gonadotropin releasing hormone agonists(GnRHa)are the relatively safe drugs widely used in clinic to treat precocious puberty.After therapy withdrawal,the patients would have normal menstrual onset,gestation and fertility.GnRHa didn't degrade uterus volume of post puberty.After cessation of GnRHa,luteinizing hormone,follicle stimulating hormone and sex hormone levels would return to those before therapy,or even exceed them.Some researches suggested that gonadotropin releasing hormone analogue might increase the risk of androgen excess and polycystic ovary syndrome.The researches apply no sufficient evidences to show that GnRHa had significant and irreversible negative influences on bone mineral density.GnRHa might have the side effect of increasing body mass index(BMI).However,researches also showed that GnRHa was helpful to decrease BMI,or not to increase it.

Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disorder. Epidemiological data evidence that NBS1 gene can be considered a susceptibility factor for cancer development.So far nine mutations localized in coding sequence of the NBS1 gene have been found at the heterozygous state in cancer patients,the 6S7del5,511A→C (I171V), 643C→T(R215W) are the most frequently described. The review will focus on the symptoms of NBS characteristics, the recent advances of NBS1 gene producethe correlation between carriers of NBS1 gene frequent heterozygous mutations and the development of malignant tumours.

Leptin participates in the whole process of pregnancy.Soluble leptin receptor has close relationship with metabolic syndrome, type 2 diabetes.Leptin can two-way regulate insulin through different signal transduction pathways.Gestational diabetes influence maternal glucose metabolism and lipid metabolism.Soluble leptin receptors adjust the utilization rate and the concentration of leptin.It can increase the leptin sensitivity and indirectly involve in the body′s endocrine metabolism process.This article reviews the change of leptin and soluble leptin receptor during the pregnancy and the feasibility as early gestational diabetes screening index.