Objective To establish the rat myocardial infarction model to observe the effects of different kinds of doses of simv-astatin for inhibiting the oxidative stress after myocardial infarction ,and to explore the potential mechanism of different doses of simvastatin for improving the rat ventricular remodeling and cardiac function .Methods The coronary artery anterior descending branch was ligated for establishing the myocardial infarction rat model and the different doses of simvastatin (20 ,40 ,60 mg · kg -1 · d-1 ) were given for intervention .After 4 weeks ,the cardiac ventricular remodeling indicators ,superoxide dismutase(SOD) and cop-per zinc superoxide dismutase(CuZn-SOD) activity in myocardium ,blood H2 O2 level were detected and the detection results were compared with those in the sham operation group .Results The rat ventricular remodeling in the myocardial infarction group (M group) was significant ,the left ventricular mass index (LVWI) was elevated ,the heart rate was increased and the hemodynamics was disordered(P<0 .05) .The SOD and CuZn-SOD expression in the myocardium and blood H2O2 expression were elevated(P<0 .05) .The LVW1 in different doses of simvastatin intervention groups were decreased compared with the myocardial infarction group(P<0 .05) ,the heart rate was decreased ,SOD and CuZn-SOD expression and blood H2 O2 expression were decreased ,the he-modynamics was improved(P<0 .05) ,especially which in the high dose atorvastatin intervention group (60 mg · kg -1 · d-1 ) were more significant .Conclusion Simvastatin reduces the expression of oxidative stress after acute myocardial infarction ,which may be one of the mechanisms for improving the ventricular remodeling and heart function ,and has certain positive correlation with dose .

OBJECTIVE:To prepare Qingrejieduhuazhuo tablets and establish the standard of quality control.METHODS:The content of baicalin in the product was determined with HPLC method.RESULTS:The linear range of baicalin concentra?tion was0.128～0.642?g/ml and correlation coefficient was0.9997.The average recovery of sample was98.31%with a RSD of0.82%(n=6).CONCLUSION:The method is suitable for the quality control of Qingrejieduhuazhuo tablets.

Objective:To discuss the performance management method for large medical equipments in hospitals.Methods:13 large medical equipments in a large hospital were selected as samples and the economic efficiency analysis method and comprehensive evaluation method were aaplied to carry out performance management of medical equipment.Results:11 sets of medical equipment had good economic returns,the remaining 2 sets of equipments had a greater degree of loss due to lack of business and lack of qualification.Conclusion:Performance management of large medical equipments would help change the efficiency management of equipment from extensive to elaborate management.

This paper gives a brief introduction of the moral norms of medicine & health websites,HONcode,and its certification in international and domestic medicine & health websites.To build a standard for healthy and clear online data environment,it was suggested that the ideas of HONcode be applied to the quality control of domestic medicine & health websites.

Objective To evaluate the relationship between hyperuricemia and nonalcoholic fatty liver disease(NAFLD) by observing the prevalence of NAFLD among healthy individuals with different levels of serum uric acid.Methods The data of 5 230 persons from medical centers for health examination were analyzed,such as height,weight,blood pressure,blood lipids,blood sugar, hepatitis-related markers, and abdominal color Doppler ultrasound examination were conducted in the fasting state.The diagnosis of NAFLD was made according to the diagnostic criteria adopted by China Institute of Liver Disease and Alcoholic Liver Disease Group.Results The incidences of overweight or obesity, hypertension,hyperlipidemia, and metabolic syndrome were raised with serum uric acid greater than 333 μmol/L in male and＞233 μmol/L in female subjects(P＜0.05 or P＜0.01). Excluding the metabolic syndrome in male subjects, the incidence of NAFLD was increased with serum uric acid,＞333 μmol/L in males or ＞233 μmol/L in females(P＜0.05 or P＜0.01). In further studies with subjects without any metabolic syndrome, the detection rate of NAFLD was higher in males than in females at the same serum uric acid level(P＜0.01). Logistic regression analysis showed that sex, body mass index, blood glucose, and triglyceride, low-density lipoprotein cholesterol, uric acid grading were risk factors of NAFLD(OR 1.344, 2.500, 1.292, 1.279, 1.244, 1.256 respectively).Conclusion A high serum uric acid level is associated with an increased risk of NAFLD.

Objective To evaluate the values of CD64 expression in diagnosis of infected patients referred to intensive care unit.Method Sixty febrile children referred to the hospital intensive care unit from 2009.11 to 2010.03 were enrolled for a retrospective study.Fever was defined as a body temperature reaching 38℃ or higher with specifically bacterial infection or highly suspected with bacterial infection or viral infection.There were 28 patients with bacterial infection and 32 with viral infection.The non-infectious diseases such as juvenile rheumatoid arthritis and Kawasaki disease were excluded.The controls were 50 healthy children asking for physical examination.On admission,CD64 were measured by using flow cytometry,and blood routine examination,ESR,PCT,blood cultures and sputum cultures were simultaneously detected in all febrile patients.Data were statistically analyzed by using SAS 16.0 software.Data are given as means±SE.Categorical variables were analyzed using X2 test and continuous variables were compared by applying paired 1-tailed t test,Significance level was set at less than 0.05.Results of them,57.1%bacterial infection patients and 71.9%viral infection patients contracted pneumonia.CD64 in bacterial infection patients、viral infection patients and the subjects of control group were(12.6±9.7),(5.4±2.42)and (2.9±0.77),respectively.The CD64 in the bacterial infection patients were significantly higher than those in the virus infection patients(F=11.002,P=0.004).Conclusions CD64 in infected children referred to a hospital intensive care unit can be clearly distinguished between bacterial infections and viral infections, providing an important guidance and a flexible strategy for clinical treatment and determine the timing of withdrawal.

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Female ; Humans ; Liver Transplantation ; adverse effects ; Male ; Mycoses ; diagnosis

OBJECTIVE: To approach efficacy of Dianning tablet in the treatment of refractoriness epilepsy.METHODS: 180 patients with refractoriness epilepsy were randomized into treatment group,control group Ⅰand control group Ⅱ(n=60).Treatment group were given Dianning tablet produced by our hospital.Control group Ⅰwere treated with carbamazepine tablet and clonazepam tablet while control group Ⅱ were treated with valproate sodium tablet and clonazepam tablet.The efficacies of three groups were compared after 6 months.RESULTS: Treatment group was better than control groups in total effective rate,seizure frequency and improvement of EEG (P

Adult ; Female ; Humans ; Male ; Meridians ; Middle Aged ; Moxibustion ; Urticaria ; therapy ; Young Adult