Adult ; Histiocytosis, Langerhans-Cell ; Humans ; Male

Invasive fungal infections(IFI) is significantly increasing in the neonatal intensive care unit recent years.The characteristics of IFI are low diagnosis rate,high mortality and being prone to involve in the nervous system.In this paper,the epidemiology,pathogens,risk factors,diagnosis,treatment and prevention of neonatal IFI are reviewed to improve the understanding of this disease.

Object To determine the change of benzoic acid contents in decoctions prepared from various combinations of the recipe named SIWUTANG by RP HPLC to provide a reference for the control of the acid level Methods 8 decoctions of P lactiflora either alone or in combination with one or more of the other 3 components, according to permutation and combination, were prepared and their benzoic acid contents determined by RP HPLC Results The content of benzoic acid in the decoction of Radix Paeonie Alba alone was found to be 2 74 mg/g, while that of the other 7 combinations varied from 0 41～1 11 mg/g Conclusion The content of benzoic acid in SIWUTANG could be lowered significantly by the presence of Radix Angelica Sinensis, Radix Rehmanniae, and Rhizoma Chuanxiong

OBJECTIVE:To further perfect our Pharmaceutical Administration Law of PRC.METHODS:Contractive methods were used to analyze comparatively the legal liabilities in US FDCA and Pharmaceutical Administration Law of PRC with regard to awarding system for reporters,penalty terms and the disposition of the confiscated drugs.RESULTS&CON?CLUSION:Compared with the PRC Pharmaceutical Administration Law,the US FDCA is more comprehensive and more consummate.We should follow the legislative spirit in FDCA and take it as a reference to improve our Pharmaceutical Ad?ministration Law.

OBJECTIVE:To provide references for the establishment of drug recall system in China.METHODS: The drug recall system in U.S.A. was introduced so as to get some enlightenment for the drug safety in China.RESULTS & CONCLUSION: We could use the drug recall system in U.S.A. for references to improve our law criterion system and carry out drug recall system on a large scale.

Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disorder. Epidemiological data evidence that NBS1 gene can be considered a susceptibility factor for cancer development.So far nine mutations localized in coding sequence of the NBS1 gene have been found at the heterozygous state in cancer patients,the 6S7del5,511A→C (I171V), 643C→T(R215W) are the most frequently described. The review will focus on the symptoms of NBS characteristics, the recent advances of NBS1 gene producethe correlation between carriers of NBS1 gene frequent heterozygous mutations and the development of malignant tumours.

ObjectiveTo explore the clinical effect of fiberoptic bronchoscope on mechanical ventilation patients with lung infection. Methods42 patients with serious lung infection acted mechanical ventilation were carried by fiberoptic bronchscope to check airstract,clear the waset,waste cultivating,and lung washing. ResultsThe waste cultivating was Positive. The conditions of 39 patients were improved effectively. The PaO2 ( t =-188. 539, P ＜0. 001 ), PaCO2 ( t =74. 481, P ＜ 0. 001 ), SaO2 ( t =-9. 025, P ＜ 0. 001 ) were statistically different after fiberoptic bronchoscope treatment. ConclusionFiberoptic bronchoscope could effectively identify the etiology and provide specif.ic antiinflamation treatment ;lung washing was beneficial for the airabstract waste extraction to improve the condition which was a relatively safe and effective method.

ObjectiveTo explore the mechanisms of proliferation and apoptosis of K562 cells induced by cytarabine. MethodsDifferent doses of cytarabine on the proliferotion at K562 cell 24h,48h,72h were detected by MTT. Cell cycle And Apoptosis rate were detected by FCM. ResultsEach concentration of cytarabine obvious inhibited the growth of K562 cells. In the same concentrations,function of proliferation inhibition with cytarabine increased by the extension of time,which showed dose and time effect relations. Cytarabine on K562 cell,G0/G1 phase cell proportion of role as cytarabine increased when extension of time, S period and the G2/M period cells were decreased.Apoptosis of K562 cell in proportion as drug concentration and effect time increases, which present Cytarabine timeconcentration dependence. CondusionCytarabine was apparent inhibition to proliferation of K562 cell leukemia cell, which could promote K562 cell apoptosis by time and concentration dependence way.

Objective:To investgate the definite spot of expression of leukemia inhibitory factor gene in mouse endometrium in the implantation window phase.Methods:By reverse transcription-polymerase chain reaction(RT-PCR),the expression of LIF gene of 20 cases of the implantation sites and the paraimplantation sites from the endometrium of the mice that were 4 days pregnant was detected.Results:The average level of LIF mRNA expression of the implantation sites was 0.5316.The average level of LIF mRNA expression of the paraimplantation sites was 0.3711.By the statistic t-test,the difference was significant( P

Leptin participates in the whole process of pregnancy.Soluble leptin receptor has close relationship with metabolic syndrome, type 2 diabetes.Leptin can two-way regulate insulin through different signal transduction pathways.Gestational diabetes influence maternal glucose metabolism and lipid metabolism.Soluble leptin receptors adjust the utilization rate and the concentration of leptin.It can increase the leptin sensitivity and indirectly involve in the body′s endocrine metabolism process.This article reviews the change of leptin and soluble leptin receptor during the pregnancy and the feasibility as early gestational diabetes screening index.