Objective:To determine the equilibrium solubility of zolmitriptan in various media and its partition coefficients for the n-octanol-water/buffer solution systems.Methods:A high performance liquid chromatography was established and used to detect the concentration of zolmitriptan;the partition coefficients for the n-octanol-water/buffer solution systems of zolmitriptan were determined by shaking flask method.Results:The equilibrium solubility of zolmitriptan in water was 12.6 g/L at 37℃.The equilibrium solubility of zolmitriptan were 1 382.0,553.0,85.2,71.5,47.1,11.5 and 4.85 g/L in buffer solutions with pH values of 3.6,4.5,6.0,6.8,7.4,8.0 and 9.0 respectively.Papp of zolmitriptan was 0.013 in water and were 0.04,0.06,0.14,0.20,0.23,0.25 and 1.44 in buffer solutions with different pH values.Conclusion:In the range of pH3.6 to pH 9.0,the equilibrium solubility of zolmitriptan was decreased while the apparent oil/water partition coefficient was increased with the increasing of pH values.

The paper introduced the methods of building model on animal model of vascular dementia in recent years,and analysed the good points and bad points of these methods.Building the right animal model of mice with vascular dementia has important meanings for deeply exploring its pathogenic mechanism,pathological characteristic and clinic diagnosis.

Objective:To evaluate the effect of the psychological intervention on heart intervention operation of the old patients.Methods:The supportive psychotherapy was employed to treat the old patients undergoing heart intervention operation.HAMA、HAMD measure forms and clinic self-edited questionnaire were adopted to carry out an investigation on 105 cases before and after heart intervention operation.Results:The psychological intervention significantly stabilized emotion of the patients;anxiety and depression were relieved after the treatment.Conclusion:The psychological intervention is helpful in treating the old patients undergoing heart intervention operation.It can promote the recovery and improve the emotion.

Objective: To evaluate the efficacy and safety of domestically made candesartan cilexetil in the treatment of mild to moderate hypertension.Methods: In randomized,double-blind and parallel control trai1,58 patients with mild and moderate essential hypertension randomly received either candesartan cilexetil at 8mg daily(=29) or irbesartan at 150mg daily(=29) for 2 weeks.The patients with poor prognosis in 2weeks(DBP≥90mmHg) received extra 1 tablet daily.Results:Significant differences in the overall response rate of candesartan or irbesartan monotherapy(75.86% VS.37.93%) was found at 2 weeks after treatment.No significant difference in the overall response rate of candesartan or irbesartan monotherapy(89.66% VS.79.33%) was found at 4 weeks after treatment.Significant differences in decreasing the range of systolic pressure in candesartan group or irbesartan group(27.52?11.90mm Hg VS.20.72?9.27 mm Hg) at sitting position and(24.59?11.87 mm Hg VS.15.90?16.22 mm Hg) at standing position were found in at 4 weeks(P

Finding the method of supervisory of nursing in peacekeeping level Ⅱ hospital.APIE program was used for controlling nurse's unstable mood,suspicion of self-worth,confliction between serving consciousness and self-protection consciousness,and for preparing nursing substances entirely but not wastefully: building up the feeling of sanctimony and responsibility;focus in constructing and maintaining of comity between the nurses under harsh condition;confirming every nurses responsibility,establishing bylaw of nursing and working routine.using the manpower resource rightly and building up a correct serving idea;paying attention to the quality of nursing and self-defending;planning and preparing the nursing substances meticulously and effectively before going abroad.The judgments from UN supervisor,managers of the hospital,patients and other staff in hospital are very good.The effect of using APIE program to run peacekeeping level Ⅱhospital is satisfied and worthy to spread.

OBJECTIVE:To investigate the biliary aerobic bacterial infection in acute cholecystitis and their susceptibility to antibacterials.METHODS:Biliary samples of 198 patients undergoing acute cholecystitis surgery in our hospital from 2003 to 2007 were sujected to culture of biliary aerobic bacteria and drug sensitivity test.RESULTS:Of the total 198 bile specimens,147 were postive in aerobic bacteria culture,of which,21 were mixed infection.A total of 225 strains were isolated,with Escherichia coli,Klebsiella pneumonia and Enterobacter representing 42.7%,22.7% and 16.9% respectively.In the drug sensitivity,all the bacteria showed different degree of resistance to antibiotics,with cephalosporines showing the higest antibiotic sensitivity.Gram-positive bacteria were the most sensitive bacteria to vancomycin while Gram-negative bacteria were the most sensitive bacteria to imipenem.CONCLUSION:Biliary bacterial culture and drug sensitivity test are necessary in acute cholecystitis surgery and drugs should be used according to the results of drug sensitivity test.

Objective To explore the influence of optimizing practical teaching of on improving the application ability and clinical thinking of acupuncture professional students.Method The students of four 2012 acupuncture and massotherapy classes in the college were randomized into experiment and control groups. In the experiment group, practical teaching reform was implemented to adopt Whole course module teaching system, establish practice teaching resource database of and construct the training teaching mode of medical records as guidance, objective and “three observations, seven practices and one comparison”. In the control group, lessons were given in sequence of “meridian and acupoints first” and “needling and moxibustion methods next” of traditional course system, and the training teaching mode of teacher demonstration-student group practice-teacher comment and the teacher-led mode of operation assessment were used. At the end of term, grades were awarded by examining based meridian drawing and acupoint location, puncturing with filiform needles and based operation. Assessment was made by the teachers and experimental group students.Result There were statistically significant differences in the grades of meridian drawing and acupoint location, based puncturing with filiform needles and based operation between the experiment and control groups (<0.01). Both the teachers and experimental group students responded that the application ability was improved to a larger extent.Conclusion The practical teaching reform of is very helpful in improving students’ comprehensive quality of skills and application abilities. standardization of based based.

Objective To establish a HPLC method for the determnation of serum concentration of isoimperatorin in rats and study pharmacokinetic characteristic of isoimperatorin in rat after drug admiaistraction. Method The concentrations of isoimperatorin in rats were determined after drug administration and the pharmacokinetic parameters of isoimperatorin were estimated by DAS2.0 computer program. Result The concentration-time profiles were fitted with open two compartment model system. The main pharmacokinetic parameters were as follows:Tmax =(1.6?0.000)h, Cmax =(15.842?0.35)mg/L, AUC0-t=(80.761?10.03)mg/(L?h), AUC0-∞=(89.45?9.34)mg/(L?h), t1/2=(5.101?0.24)h. Conclusion The method is appropriate for the determination and pharmacokinetic study of isoimperatorin in rats after drug administration.

Objective To explore the function and mechanism of Dihuang Yinzi (DHYZ) in promoting learning and memory and delaying brain aging. Methods The Wistar rats aged 20 months were randomly assigned to receive oral administration of 6, 12, 18 g?kg~ -1 ?d~ -1 DHYZ, or 2 ml/d normal saline (control) for 30 d (n=12 in each group), then space memory was detected with Morris Water Maze, and expression of synaptophysin (SYP) and extracellular regulated protein (ERK) were measured by immunohistochemistry and Western blotting. Results Rats administrated with DHYZ showed shorter mean escape latency (P

Objective: To know the occasion and how the military in-patients understood the contents of health education, to discuss how to conduct the health education pertinently and how to make the military in-patients master the information and skill to get well effectively in a short time. Methods: By referring to literature samples and the main contents of health education of sections in our hospital, we designed a questionnaire including the main contents of health education、the fashion and the occasion of conduction in different phase of hospitalization, together with three subjects and 44 items, and we investigated 312 military in-patients in the way of questionnaire in combination of opening and closing. Results: Military in-patients considered the correlative knowledge of getting well as the shoe pinches of the main contents of health education. The communication between doctors、nurses and pation should be strengthened; Communication through talking and offering written materials were the two primary fashions of health education; The medical personnel and military in-patients disagreed in the time arranging of health education. Conclusion: We suggest the adoption of the educational method of ”advantage health education contents increased by degrees” to conduct health education; paramedic in all levels should pay attention to the feelings of military in patients, pay attention to the rational arrangement of the health education time and contents. We emphasize the training of paramedic's communication skills of talking and writing.