1.Patch testing with different allergen series: Retrospective study from Selayang Hospital,Malaysia
Malaysian Journal of Dermatology 2011;27(-):20-20
Background:
Majority of the hospitals in Malaysia have limited allergen series for patch testing. Since January 2011, Department of Dermatology in Selayang Hospital has extended its number of allergen series available for testing.
Objectives:
The aim of this study was to evaluate whether other series besides the European baseline series (EBS) deserve to be tested on suspected patient with contact dermatitis.
Methods:
Patch test results of patients visiting Dermatology clinic in Selayang Hospital from January 2001 to June 2011 were
reviewed retrospectively.
Results:
Out of 129 patients who were patch tested, 98 (76%) patients had positive patch test, 30 (23.3%) patients had negative patch test and 1 (0.7%) patient had ‘Angry back’ reaction. The most commonly positive allergens were Nickel sulfate 45 (34.9%), Cobalt chloride 21 (16.3%), Potassium dichromate 15 (11.6%) and Balsam Peru 15 (11.6%). None of the patient had positive patch test to Mercaptobenzothiazole, Sesquiterpene lactone mix, Fragrance mix II and Lyral in the (EBS). The
number of patient that will be missed if certain series are not tested were Textile Colours & Finish (TF) (n=4/7, 57.1%), Plastic & Glues (PG) (n=4/19, 21.1%), Hairdressing (n=1/5, 20%), Cosmetic (n=2/12, 16.7%), Rubber Additives (n=12/77, 15.6%), Medicament (n=1/9, 11.1%), Plant (n=0/5, 0%), Cutaneous Adverse Drug Reaction (n=0/3, 0%) and Leg Ulcer (n=0/1, 0%).
Conclusion:
The absence of positive patch test to Mercaptobenzothiazole, Sesquiterpene lactone mix, Fragrance mix II and Lyral does
not support inclusion in the EBS in our region. Additional series especially TF and PG are important series to be tested in suspected patient.
2.Treatment of Erythema Nodosum Leprosum (ENL) with high-dose Clofazimine in patients with Lepromatous Leprosy
Malaysian Journal of Dermatology 2010;25(-):7-9
ENL is a type ll leprosy reaction and occurs in
people with borderline lepromatous and
lepromatous leprosy, usually as a complication
following treatment. The treatment of choice for
ENL is prednisolone in view of its’ ready
availability and affordability1. Howeve r,
glucocorticoid therapy, even in low doses, can
produce substantial toxicity. The risk is clearly
greater as the dose increases. However, in cases
where there are steroid-induced complications,
high-dosed clofazimine may be used to reduce or
withdraw corticosteroids in steroid-dependant
cases2,3. We described 2 steroid-dependent ENL
patients with steroid-induced complications who
are successfully managed with the addition of highdosed
clofazimine and the resultant weaning down
of systemic glucocorticoids.
3.Erythroderma - A retrospective study with special emphasis on good prognosis
Peter Ch’ng WB ; Adam B ; Rohna R
Malaysian Journal of Dermatology 2011;26(-):1-5
Background Erythroderma is a serious condition in itself, quite apart from hazards associated with
the underlying disease, and is sometimes fatal. Prognostic studies are rare in the literature and to date
there are no published studies to identify the factors that can determine good prognosis.
Objectives The aim of the study is to determine the factors that can prognosticate the good outcome
of erythroderma.
Methodology Cross sectional study from patients diagnosed to have erythroderma between 2003
and 2007 were analyzed with regard to age, sex, race, underlying medical illness, aetiology, duration
of rash before diagnosis of erythroderma, response to topical therapy and prognosis.
Results Four variables (aetiology, gender, duration of rash before being diagnosed as erythroderma
and response to topical therapy) were associated with good prognosis. These variables were
statistically significant from univariate analysis. When these variables were included into the binary
logistic model, the study did not have enough evidence to proof that ‘aetiology’ and ‘gender’ can
determine good prognosis. Response to topical therapy and shorter duration of rash (equal and less
than 120 days) were significant with odds ratio (CI) of 4.11 (1.556, 10.885) and 4.608 (1.903,
11.155) respectively.
Conclusion Shorter duration of rash and response to topical therapy are important factors to
determine a good prognosis.
4.Opportunity for improvement in monitoring of dermatological patients by nurses
Norhasmie Ramli ; Kasmawati T ; Noradiah J ; Rohna R
Malaysian Journal of Dermatology 2011;27(-):29-29
Background
Nursing progress notes in Selayang Hospital was found to be non-compliance according to Malaysian local accreditation
bodies in 2007. In June 2008, Department of Dermatology were assigned with dedicated nurses.
Aim
To look into the quality of monitoring of Dermatology patients by nurses which is reflected by the content in nursing
progress notes before and after being taught by Dermatology nurses.
Methodology
A retrospective comparative audit of the quality of nursing progress notes in ward patients that required Dermatology
management in May 2006 and May 2009 in Selayang Hospital was performed. Parameters assessed include the patient’s
general condition, skin symptoms and signs, alerting doctor whenever there is change in skin condition and nursing
intervention. Exclusion criteria include documentation by the same nurse at different times.
Results
325 nursing progress notes were reviewed in 2006 and also in 2009. 70% of nurses described the symptoms and signs
of skin lesions at that point of time in 2009 whereas only 5% of nurses did that in 2006. Documentation of intervention
performed for the current skin lesions in 2009 and 2006 were 81% and 48% respectively. Only 4% of nurses informed
doctor on finding a change in skin condition 2006 as compared to 71% in 2009.
Conclusion
The audit shows that designated skin nurses can assist the ward nurses to improve their clinical documentation.
6.Pattern Of Allergic Contact Dermatitis In School Children In Selayang Hospital, Malaysia
Sharifah Rosniza SNC ; Rohna R ; Kasmawati T ; Norhasmie R ; Nor Hayati AJ
Malaysian Journal of Dermatology 2013;31(-):13-18
Background: Allergic contact dermatitis (ACD) was thought to be infrequent in children. However,
there was an increasing number of case reports and cross-sectional studies in the past three decades
indicating that ACD is not as rare as previously thought. Understanding the pattern of allergic contact
dermatitis in children would help with the diagnosis and prevention of this disease.
Aim: This study explored the spectrum of contact allergens in schoolchildren.
Methodology: This is a retrospective analysis of all primary and secondary schoolchildren who
underwent patch test at the Department of Dermatology, Hospital Selayang, Malaysia between January
2012 and March 2013. Patch tests were performed with European Baseline Series and other additional
commercial series from Chemotechnique Diagnostics in IQ chambers. The parameters studied included
sites of dermatitis, positive patch test reactions and sources of the allergens. Readings were recorded
according to the International Contact Dermatitis Research Group recommendation. Results were
analyzed using the SPSS Version 12.0.
Results: 84 out of 327 (25.7%) patients who underwent patch tests were primary and secondary
schoolchildren. Of the 84 schoolchildren, 60.7% had at least one positive patch test reaction. The most
common allergens were preservatives found in cosmetic series (51%), rubber chemicals (47.1%),
nickel sulfate (31.3%), fragrances (19.6%) and topical medicaments (19.6%). The majority (86%) of
patients with facial dermatitis were positive to allergens in dental series, whereas 41.9% of patients
with dermatitis involving the upper limbs and 50% of patients with dermatitis involving the lower
limbs had positive patch test to rubber chemicals. Patients with dermatitis involving the trunk mostly
had positive patch test to fragrances (50%). Sources of fragrances were mainly found in toiletries,
topical medicaments and cosmetics.
Discussion: This results of this study were interesting because of the high rate of sensitization to
preservatives, mainly paraben mix. There were also high sensitization rates to rubber chemicals, which
could be due to contact with rubberized shoes, sports equipment and stationery.
Conclusions: Schoolchildren with face, limbs or trunk dermatitis should be patch tested with additional
dental, rubber and fragrance series respectively.