1.Clinical practice guidelines on the diagnosis and treatment of gastroesophageal reflux disease (GERD).
Sollano José D. ; Romano Rommel P. ; Ibañez-Guzman Leticia ; Lontok Marie Antoinette DC. ; de Ocampo Sherrie Q. ; Policarpio Allan A. ; de Guzman Roberto N. ; Dalupang Carmelita D. ; Galang Augusto Jose G. ; Olympia Ernesto G. ; Chua Maria Anna L. ; Moscoso Bernadette A. ; Tan Jose A. ; Pangilinan John Arnel N. ; Vitug Arnold O. ; Naval Marichona C. ; Encarnacion Danilo A. ; Sy Peter P. ; Ong Evan G. ; Cabahug Oscar T. ; Daez Maria Lourdes O. ; Ismael Albert E. ; Bocobo Joseph C
Philippine Journal of Internal Medicine 2015;53(3):1-17
In the last two decades gastroesophageal reflux disease (GERD), initially thought to be a disease only common in the West, is described increasingly in Asia, including the Philippines. A recent local report indicated that the prevalence of erosive esophagitis (EE), a common complication of GERD, has more than doubled, i.e., 2.9% to 6.3%, between the two time periods of 1994-1997 and 2000-2003, respectively. GERD causes recurrent annoying symptoms which are common reasons for clinic visits and consultations thus, it is the objective of these guidelines to provide both primary care physicians (PCPs) and specialists a current, evidence-based, country-specific recommendations for the optimal management of GERD. These guidelines are intended to empower PCPs to make a clinic-based diagnosis of GERD, to start an empiric acid-suppressive therapy in the appropriate patient,and direct them to select which GERD patient may need to undergo investigations to ascertain further the diagnosis of GERD or to assess outcomes of therapy. We acknowledge that studies published in the future may influence the impact on our confidence on the recommendations enumerated in these guidelines thus, we commit to update this document when it is deemed appropriate.
Physicians, Primary Care ; Prevalence ; Specialization ; Gastroesophageal Reflux ; Ambulatory Care ; Esophagitis ;
2.A rare case of systemic mastocytosis in a 72-year-old female with gastrointestinal bleeding.
Nathania Maxene P. Sianghio ; Maria Claudia Chavez ; Roli June Chavez ; Roberto De Guzman
Philippine Journal of Internal Medicine 2024;62(3):177-182
Mastocytosis is a rare disorder that results from the clonal proliferation of abnormal mast cells which accumulates in the skin and extracutaneous organs. Its prevalence is estimated at 1 in 10,000 persons. Cutaneous mastocytosis occurs in less than 5% of adults while adult-onset mastocytosis is suggestive of systemic progression. Involvement of the gastrointestinal tract occurs in 14-85% of patients diagnosed with systemic mastocytosis. This case involves a 72-year-old female previously diagnosed with cutaneous mastocytosis who presented with gastrointestinal symptoms fifteen years later. Workups done included CT scan, colonoscopy, and bone marrow aspiration. Colonic and bone marrow tissue samples revealed eosinophilia with CD117 positivity. The patient was started on therapy with imatinib. No recurrence of hematochezia was observed on follow-up.
Human ; Female ; Aged: 65-79 Yrs Old ; Mastocytosis, Systemic ; Imatinib ; Imatinib Mesylate
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