[Objective] To optimize the extraction process of Weiyanping granules. [Method]The orthogonal test method was adopted to explore the influences of 4 factors(quantity of water,soaking time,extraction time and times) on the yielding rate of berberine and dry paste rate. [Results]Analysis by synthesis,the optimum condition for extraction was A2B3C1D3.The medicinal substances should be soaked in 10 times water for 2 hours and distilled for 3 times,with 1 hour each time.[Conclusion]The experiment result showed that the optimum extraction process condition was stable,reasonable and economical,which could be used to guide industrialized production.