Introduction: Polycystic ovarian syndrome (PCOS) has been recognized as a risk factor for metabolic dysfunction. The objective of this study was to determine the association of each PCOS phenotype with the risk for prediabetes and diabetes mellitus (DM). Methods: This was a cross-sectional study by chart review of PCOS patients classified into 4 phenotypes, who consulted at outpatient clinics in Makati Medical Center. Odds ratio using logistic regression was used to determine association between the PCOS phenotype and having prediabetes or DM Type 2. Results: One hundred thirty-four records of eligible females diagnosed with PCOS classified as Phenotype D (52%), Phenotype A (22%), Phenotype C (19%) and Phenotype B (7.5%), were included. Pre-diabetes was diagnosed in 39.6%, and DM type 2 in 7.5% of the women. Univariate association of phenotype and outcome revealed that DM is significantly more common among phenotypes A and D while prediabetes is significantly most common among phenotype D. However, multivariate regression did not show any positive association between phenotypes and risk for prediabetes and DM. Conclusion Phenotypes A and C were significantly negatively associated with the risk of prediabetes or DM type 2. Obesity and abdominal adiposity were aggravating factors that increased metabolic risk.
Prevalence ; Diabetes Mellitus ; Prediabetic State