1.Passive Warming using a Heat-Band versus a Resistive Heating Blanket for the Prevention of Inadvertent Perioperative Hypothermia during Laparotomy for Gynaecological Surgery
Wan Muhd Shukeri Wan Fadzlina ; Wan Hassan Wan Mohd Nazaruddin ; Mohamad Zaini Rhendra Hardy
Malaysian Journal of Medical Sciences 2016;23(2):28-37
Background: Inadvertent perioperative hypothermia (IPH) is a common problem, despite advancements in a variety of warming systems. The use of a resistive heating blanket (RHB) is a common but costly approach to patient warming. We have introduced the use of a heat-band in our centre as a cost-effective alternative to the RHB for patient warming. The efficacy of the heat-band in preventing IPH during laparotomy for gynaecological surgeries was compared with that of the RHB. Methods: Thirty-two patients undergoing surgeries under combined general-epidural anaesthesia, with an expected duration of surgery of 2–4 h, were randomised to receive either the heat-band or RHB. The core body temperatures of the two groups were compared at several perioperative times, in addition to the incidence of post-anaesthesia shivering, time to extubation and intraoperative blood loss. Results: The core body temperatures were comparable between the two groups in the pre-operative period, immediately after the induction of anaesthesia and skin incision, 1 h after the incision, at the time of complete skin closing, at extubation, upon arrival to the recovery room and 1 h post-operatively. There were no significant between-group differences in the incidence of post-anaesthesia shivering, time to extubation and intra-operative blood loss. Conclusion: The heat-band is as effective as the RHB in preventing IPH and its complications in gynaecological laparotomies.
2.Target-controlled Infusion Propofol Versus Sevoflurane Anaesthesia for Emergency Traumatic Brain Surgery: Comparison of the Outcomes
Wan Mohd Nazaruddin Wan Hassan ; Yusnizah Mohd Nasir ; Rhendra Hardy Mohamad Zaini ; Wan Fadzlina Wan Muhd Shukeri
Malaysian Journal of Medical Sciences 2017;24(5):73-82
Background: The choice of anaesthetic techniques is important for the outcome of
traumatic brain injury (TBI) emergency surgery. The objective of this study was to compare
patient outcomes for target-controlled infusion (TCI) of propofol and sevoflurane anaesthesia.
Methods: A total of 110 severe TBI patients, aged 18–60, who underwent emergency
brain surgery were randomised into Group T (TCI) (n = 55) and Group S (sevoflurane) (n = 55).
Anaesthesia was maintained in Group T with propofol target plasma concentration of 3–6 μg/mL
and in Group S with minimum alveolar concentration (MAC) of sevoflurane 1.0–1.5. Both groups
received TCI remifentanil 2–8 ng/mL for analgesia. After the surgery, patients were managed in
the intensive care unit and were followed up until discharge for the outcome parameters.
Results: Demographic characteristics were comparable in both groups. Differences
in Glasgow Outcome Scale (GOS) score at discharge were not significant between Group T and
Group S (P = 0.25): the percentages of mortality (GOS 1) [27.3% versus 16.4%], vegetative and
severe disability (GOS 2–3) [29.1% versus 41.8%] and good outcome (GOS 4–5) [43.6% versus
41.8%] were comparable in both groups. There were no significant differences in other outcome
parameters.
Conclusion: TCI propofol and sevoflurane anaesthesia were comparable in the outcomes
of TBI patients after emergency surgery.
3.Balanced Fluid Versus Saline-Based Fluid in Post-operative Severe Traumatic Brain Injury Patients: Acid Base and Electrolytes Assessment
Mohamad Hasyizan Hassan ; Wan Mohd Nazaruddin Wan Hassan ; Rhendra Hardy Mohd Zaini ; Wan Fadzlina Wan Muhd Shukeri ; Huda Zainal Abidin ; Chong Soon Eu
Malaysian Journal of Medical Sciences 2017;24(5):83-93
Background: Normal saline (NS) is a common fluid of choice in neurosurgery and neurointensive
care unit (ICU), but it does not contain other electrolytes and has the potential to cause
hyperchloremic metabolic acidosis with prolonged infusion. These problems may be reduced
with the availability of balanced fluid (BF), which becomes a more physiological isotonic solution
with the presence of complete electrolyte content. This study aimed to compare the changes in
electrolytes and acid–base between NS and BF (Sterofundin® ISO) therapy for post-operative
severe traumatic brain injury (TBI) patients in neuro-ICU.
Methods: Sixty-six severe TBI patients who required emergency craniotomy or
craniectomy and were planned for post-operative ventilation were randomised into NS (n = 33)
and BF therapy groups (n = 33). The calculation of maintenance fluid given was based on the
Holliday-Segar method. The electrolytes and acid–base parameters were assessed at an 8 h
interval for 24 h. The data were analysed using repeated measures ANOVA.
Results: The NS group showed a significant lower base excess (-3.20 versus -1.35,
P = 0.049), lower bicarbonate level (22.03 versus 23.48 mmol/L, P = 0.031), and more
hyperchloremia (115.12 versus 111.74 mmol/L, P < 0.001) and hypokalemia (3.36 versus 3.70
mmol/L, P < 0.001) than the BF group at 24 h of therapy. The BF group showed a significantly
higher level of calcium (1.97 versus 1.79 mmol/L, P = 0.003) and magnesium (0.94 versus 0.80
mmol/L, P < 0.001) than the NS group at 24 h of fluid therapy. No significant differences were
found in pH, pCO2, lactate, and sodium level.
Conclusion: BF therapy showed better effects in maintaining higher electrolyte
parameters and reducing the trend toward hyperchloremic metabolic acidosis than the NS
therapy during prolonged fluid therapy for postoperative TBI patients.
4.Awake Craniotomy: A Case Series of Anaesthetic Management using a Combination of Scalp Block, Dexmedetomidine and Remifentanil in Hospital Universiti Sains Malaysia
W Mohd Nazaruddin W Hassan ; Mohd Fahmi Lukman ; Laila Abd Mukmin ; Zamzuri Idris ; Abdul Rahman Izaini Ghani ; Rhendra Hardy Mohamad Zaini
The Medical Journal of Malaysia 2013;68(1):64-66
Awake craniotomy is a brain surgery in patients who are
kept awake when it is indicated for certain intracranial
pathologies. The anaesthetic management strategy is very
important to achieve the goals of the surgery. We describe a series of our first four cases performed under a combination of scalp block and conscious sedation. Scalp block was performed using a mixture of ropivacaine 0.75% and adrenaline 5 μg/ ml administered to the nerves that
innervate the scalp. Conscious sedation was achieved with
a combination of two recently available drugs in our country, dexmedetomidine (selective α 2-agonist) and remifentanil (ultra-short acting opioid). Remifentanil was delivered in a target controlled infusion (TCI) mode.
5.A Comparison Between Measured Maxillopharyngeal Angle On Lateral Cervical Radiograph with Modified Mallampati Classification In Predicting Difficult Larnygoscopy: A Blinded Interventional Study
Mohamad Hasyizan HASSAN ; Eng Ming FUNG ; Rhendra Hardy Mohd Zaini ; Shamsul Kamalrujan HASSAN ; Praveena SEEVAUNNAMTUM ; Mohd Zulfakar MAZLAN ; Nik Abdullah Nik Mohamad
Malaysian Journal of Medicine and Health Sciences 2018;14(2):51-56
Background: Existing techniques of predicting difficult laryngoscopy are inadequate requiring evaluation of Maxillopharyngeal Angle (MP-A) on lateral cervical radiograph described. Objectives: This study aimed to compare MP-A test with Modified Mallapati Test (MMT) in predicting their diagnostic values and Area Under Curve of Receiver Operating Characteristic Curve (AUCROCC) of both test. Methods: This is a double blinded interventional study of 93 patients. Each patient’s MMT score was assessed during preoperative assessment and subsequent MP-A test done by obtaining lateral cervical radiograph with the head in neutral position. Laryngeal view was assessed using Cormack-Lehane grade after induction of anesthesia, was used as reference standard to determine the diagnostic values of MMT and MP-A respectively. Results: The MP-Acompared to MMT in predicting difficult larngoscopy had higher sensitivity (77.78 vs 44.44) specificity (88.10 vs 67.86) and accuracy (87.10 vs 65.59) with higher Odd Ratio(26.12 vs 1.68). The AUCROCC was significantly higher in MP-A test 0.83(95%CI: 0.67, 0.99) (P = 0.001) vs MMT 0.56(95%CI: 0.36, 0.76) (P = 0.546) with LR+ of 6.53 vs 1.38. Conclusion: The Maxillopharyngeal Angle test was superior in predicting difficult laryngoscopy as compared to Modified Mallampati Test.difficult intubation